YMR132C_p / JLP2

Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR132C / JLP2

Click on Significant Values for Screen Details ID:SGTC_246|Compound:cycloheximide|FD-Score:5.45|P-value:7.39E-11 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.24|P-value:6.31E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.61|P-value:9.80E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.00|P-value:2.19E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.57|P-value:1.42E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.77|P-value:5.98E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.05|P-value:1.78E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.93|P-value:3.00E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.11|P-value:1.36E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.66|P-value:9.25E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.96|P-value:1.67E-6 ID:SGTC_1689|Compound:st020265|FD-Score:5.09|P-value:1.17E-9 ID:SGTC_1948|Compound:st076329|FD-Score:2.76|P-value:6.04E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.12|P-value:6.76E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-2.63|P-value:9.02E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.56|P-value:1.48E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.71|P-value:5.51E-6 ID:SGTC_2438|Compound:5259590|FD-Score:4.55|P-value:4.52E-8 ID:SGTC_2440|Compound:5628896|FD-Score:-2.92|P-value:2.66E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.89|P-value:3.59E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.44|P-value:9.23E-8 ID:SGTC_2706|Compound:st078239|FD-Score:-3.68|P-value:6.69E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.58|P-value:2.79E-11 ID:SGTC_2798|Compound:7813637|FD-Score:2.84|P-value:4.37E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.62|P-value:9.63E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.84|P-value:4.39E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.32|P-value:4.94E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-2.74|P-value:5.79E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-2.84|P-value:3.83E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:5.45|P-value:7.39E-11 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.24|P-value:6.31E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-2.61|P-value:9.80E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.00|P-value:2.19E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.57|P-value:1.42E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:2.77|P-value:5.98E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.05|P-value:1.78E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:2.93|P-value:3.00E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.11|P-value:1.36E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.66|P-value:9.25E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.96|P-value:1.67E-6 ID:SGTC_1689|Compound:st020265|FD-Score:5.09|P-value:1.17E-9 ID:SGTC_1948|Compound:st076329|FD-Score:2.76|P-value:6.04E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.12|P-value:6.76E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-2.63|P-value:9.02E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.56|P-value:1.48E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.71|P-value:5.51E-6 ID:SGTC_2438|Compound:5259590|FD-Score:4.55|P-value:4.52E-8 ID:SGTC_2440|Compound:5628896|FD-Score:-2.92|P-value:2.66E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.89|P-value:3.59E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.44|P-value:9.23E-8 ID:SGTC_2706|Compound:st078239|FD-Score:-3.68|P-value:6.69E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.58|P-value:2.79E-11 ID:SGTC_2798|Compound:7813637|FD-Score:2.84|P-value:4.37E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-2.62|P-value:9.63E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.84|P-value:4.39E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.32|P-value:4.94E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-2.74|P-value:5.79E-4 ID:SGTC_3321|Compound:9137793|FD-Score:-2.84|P-value:3.83E-4

Top fitness defect scores for YMR132C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2794 7785382 5.58 27.3 µM 2.79E-11 6 1.21E-8
2 SGTC_246 cycloheximide 5.45 667.0 µM 7.39E-11 6 2.45E-8
3 SGTC_1689 st020265 5.09 53.5 µM 1.17E-9 8 1.84E-7
4 SGTC_2438 5259590 4.55 200.0 µM 4.52E-8 11 2.64E-6
5 SGTC_2447 5741742 4.44 33.8 µM 9.23E-8 11 4.46E-6
6 SGTC_2126 5251174 4.12 33.9 µM 6.76E-7 26 1.91E-5
7 SGTC_1634 st006576 3.96 41.0 µM 1.67E-6 TSC3-RPN4 19 3.71E-5
8 SGTC_965 1291-5240 3.57 308.0 µM 1.42E-5 41 1.79E-4
9 SGTC_2247 cerulenin 3.56 830.0 nM 1.48E-5 28 1.85E-4
10 SGTC_2976 9009005 3.32 19.5 µM 4.94E-5 49 4.49E-4
11 SGTC_1251 0490-5699 3.11 265.0 µM 1.36E-4 75 9.46E-4
12 SGTC_1239 0337-0584 3.05 35.4 µM 1.78E-4 unfolded protein response 104 0.00116
13 SGTC_758 0868-0029 3.00 16.0 µM 2.19E-4 36 0.00135
14 SGTC_1245 0418-0076 2.93 17.2 µM 3.00E-4 ERG2 77 0.00170
15 SGTC_2442 5158906 2.89 48.5 µM 3.59E-4 72 0.00194
16 SGTC_2798 7813637 2.84 45.5 µM 4.37E-4 99 0.00224
17 SGTC_2938 9059746 2.84 27.3 µM 4.39E-4 fatty acid desaturase (OLE1) 94 0.00225
18 SGTC_968 1309-0633 2.77 340.0 µM 5.98E-4 65 0.00284
19 SGTC_1948 st076329 2.76 66.6 µM 6.04E-4 101 0.00286
20 SGTC_1312 1218-2183 2.66 165.0 µM 9.25E-4 58 0.00392

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 2.23E-27 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.147 9.84E-18 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.147 1.52E-17 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.146 2.11E-17 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.127 1.69E-13 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.127 1.90E-13 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.122 1.68E-12 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.119 4.50E-12 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.115 2.41E-11 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.114 4.02E-11 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.114 4.49E-11 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.113 5.65E-11 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.111 1.45E-10 YOL139C CDC33 het mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
0.110 1.73E-10 YGR174W-A_p YGR174W-A_p hom Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis
0.107 5.07E-10 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor