YMR136W / GAT2

Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR136W / GAT2

Click on Significant Values for Screen Details ID:SGTC_122|Compound:0236-0016|FD-Score:-3.33|P-value:4.20E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.65|P-value:1.25E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.77|P-value:8.36E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.87|P-value:5.17E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.19|P-value:6.77E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.38|P-value:3.48E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.19|P-value:1.32E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.24|P-value:5.78E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.08|P-value:9.92E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.38|P-value:5.41E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.09|P-value:2.04E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.73|P-value:8.89E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.34|P-value:3.95E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.67|P-value:1.34E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.08|P-value:2.09E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:8.04|P-value:3.30E-16 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.94|P-value:3.76E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.40|P-value:4.90E-6 ID:SGTC_2792|Compound:7535235|FD-Score:4.18|P-value:1.36E-5 ID:SGTC_2799|Compound:7812892|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.45|P-value:2.68E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-5.57|P-value:1.14E-8 ID:SGTC_2935|Compound:9038016|FD-Score:3.09|P-value:9.66E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-5.68|P-value:6.00E-9 ID:SGTC_3198|Compound:9112019|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.27|P-value:5.04E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:-3.33|P-value:4.20E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:3.65|P-value:1.25E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:4.77|P-value:8.36E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:7.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.87|P-value:5.17E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.19|P-value:6.77E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-3.38|P-value:3.48E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.19|P-value:1.32E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.24|P-value:5.78E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.08|P-value:9.92E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.63|P-value:1.34E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.38|P-value:5.41E-6 ID:SGTC_1996|Compound:st072960|FD-Score:4.09|P-value:2.04E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.73|P-value:8.89E-5 ID:SGTC_2286|Compound:7945697|FD-Score:3.34|P-value:3.95E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.67|P-value:1.34E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.08|P-value:2.09E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:8.04|P-value:3.30E-16 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.94|P-value:3.76E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.40|P-value:4.90E-6 ID:SGTC_2792|Compound:7535235|FD-Score:4.18|P-value:1.36E-5 ID:SGTC_2799|Compound:7812892|FD-Score:4.19|P-value:1.26E-5 ID:SGTC_2918|Compound:7977171|FD-Score:3.45|P-value:2.68E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-5.57|P-value:1.14E-8 ID:SGTC_2935|Compound:9038016|FD-Score:3.09|P-value:9.66E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-5.68|P-value:6.00E-9 ID:SGTC_3198|Compound:9112019|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.27|P-value:5.04E-4

Top fitness defect scores for YMR136W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2764 methyldopa 8.04 94.7 µM 3.30E-16 2 4.33E-16
2 SGTC_399 oxolinic acid 4.77 75.0 µM 8.36E-7 1 9.22E-7
3 SGTC_2363 9053361 4.67 176.0 µM 1.34E-6 Golgi 20 1.48E-6
4 SGTC_2774 tamoxifen 4.40 10.9 µM 4.90E-6 10 5.32E-6
5 SGTC_1698 5-fluorocytosine 4.38 1.1 µM 5.41E-6 exosome 5 5.88E-6
6 SGTC_2799 7812892 4.19 81.8 µM 1.26E-5 superoxide 25 1.37E-5
7 SGTC_1031 k035-0009 4.19 16.0 µM 1.32E-5 19 1.42E-5
8 SGTC_2792 7535235 4.18 81.8 µM 1.36E-5 fatty acid desaturase (OLE1) 28 1.47E-5
9 SGTC_1996 st072960 4.09 66.8 µM 2.04E-5 12 2.20E-5
10 SGTC_2763 lisinopril 4.08 49.3 µM 2.09E-5 11 2.24E-5
11 SGTC_2770 toltrazuril 3.94 17.5 µM 3.76E-5 27 4.02E-5
12 SGTC_453 enantio-paf c16 3.87 10.0 µM 5.17E-5 150 5.52E-5
13 SGTC_2013 4024628 3.73 200.0 µM 8.89E-5 51 9.46E-5
14 SGTC_285 1486-1325 3.65 46.0 µM 1.25E-4 25 1.33E-4
15 SGTC_1331 1472-0049 3.63 76.2 µM 1.34E-4 29 1.42E-4
16 SGTC_1151 3909-8316 3.59 15.3 µM 1.56E-4 27 1.65E-4
17 SGTC_2630 antimycin a 3.53 100.0 µM 1.94E-4 mitochondrial processes 54 2.05E-4
18 SGTC_1411 3909-8223 3.45 150.0 µM 2.66E-4 22 2.80E-4
19 SGTC_2918 7977171 3.45 22.1 µM 2.68E-4 41 2.83E-4
20 SGTC_2286 7945697 3.34 125.0 µM 3.95E-4 79 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.32E-19 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.144 5.06E-17 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.128 1.06E-13 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
0.128 1.08E-13 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.126 2.38E-13 YGL226W MTC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
0.124 6.80E-13 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.121 2.32E-12 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.114 3.50E-11 YER079W_p YER079W_p hom Putative protein of unknown function
0.110 1.53E-10 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.102 2.67E-9 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 2.84E-9 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.102 3.06E-9 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.092 8.38E-8 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
0.092 8.31E-8 YDR265W PEX10 hom Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
0.089 2.29E-7 YML066C SMA2 hom Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation