YMR139W / RIM11

Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR139W / RIM11

Click on Significant Values for Screen Details ID:SGTC_32|Compound:0928-0142|FD-Score:3.57|P-value:9.07E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.40|P-value:2.17E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.98|P-value:1.71E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.69|P-value:6.20E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:4.68E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.88|P-value:2.65E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.05|P-value:1.24E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.91|P-value:2.35E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.70|P-value:5.93E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.59|P-value:9.39E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.06|P-value:1.18E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.28|P-value:4.16E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.07|P-value:1.15E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.04|P-value:1.29E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.64|P-value:1.20E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.03|P-value:1.36E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.58|P-value:8.67E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.60|P-value:9.12E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.71|P-value:5.69E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.27E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.96|P-value:1.88E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.46|P-value:1.62E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.22|P-value:5.49E-5 ID:SGTC_1756|Compound:st041558|FD-Score:2.73|P-value:5.17E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.96|P-value:1.89E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.02|P-value:1.43E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.76|P-value:4.55E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:2.14E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.64|P-value:6.17E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-3.12|P-value:9.03E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.46|P-value:1.62E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.43|P-value:1.93E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:1.13E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.76|P-value:4.53E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.90|P-value:1.41E-6 ID:SGTC_2487|Compound:5918373|FD-Score:4.26|P-value:1.58E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.64|P-value:7.57E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:1.86E-6 ID:SGTC_2919|Compound:7978188|FD-Score:2.91|P-value:2.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.43|P-value:1.93E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-2.63|P-value:8.03E-4 ID:SGTC_3311|Compound:9131146|FD-Score:2.69|P-value:6.09E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.57|P-value:9.07E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.40|P-value:2.17E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.98|P-value:1.71E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:2.69|P-value:6.20E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.75|P-value:4.68E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.88|P-value:2.65E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.05|P-value:1.24E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.91|P-value:2.35E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-2.70|P-value:5.93E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-2.59|P-value:9.39E-4 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.06|P-value:1.18E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.28|P-value:4.16E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.07|P-value:1.15E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.04|P-value:1.29E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.64|P-value:1.20E-8 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.03|P-value:1.36E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.58|P-value:8.67E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.60|P-value:9.12E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:2.71|P-value:5.69E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.50|P-value:1.27E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.96|P-value:1.88E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.46|P-value:1.62E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.22|P-value:5.49E-5 ID:SGTC_1756|Compound:st041558|FD-Score:2.73|P-value:5.17E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:2.96|P-value:1.89E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.02|P-value:1.43E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.76|P-value:4.55E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:2.14E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.64|P-value:6.17E-6 ID:SGTC_2283|Compound:7944793|FD-Score:-3.12|P-value:9.03E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.46|P-value:1.62E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.43|P-value:1.93E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.07|P-value:1.13E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.76|P-value:4.53E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.90|P-value:1.41E-6 ID:SGTC_2487|Compound:5918373|FD-Score:4.26|P-value:1.58E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:2.64|P-value:7.57E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.85|P-value:1.86E-6 ID:SGTC_2919|Compound:7978188|FD-Score:2.91|P-value:2.34E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.43|P-value:1.93E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-2.63|P-value:8.03E-4 ID:SGTC_3311|Compound:9131146|FD-Score:2.69|P-value:6.09E-4

Top fitness defect scores for YMR139W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2487 5918373 4.26 44.0 µM 1.58E-7 9 1.03E-5
2 SGTC_2483 5729050 3.90 27.2 µM 1.41E-6 27 4.81E-5
3 SGTC_2798 7813637 3.85 45.5 µM 1.86E-6 35 5.86E-5
4 SGTC_2103 5378138 3.64 10.0 µM 6.17E-6 24 1.36E-4
5 SGTC_32 0928-0142 3.57 34.1 µM 9.07E-6 TSC3-RPN4 11 1.79E-4
6 SGTC_2316 5844804 3.46 197.4 µM 1.62E-5 56 2.70E-4
7 SGTC_67 0335-0847 3.40 266.0 µM 2.17E-5 ubiquinone biosynthesis & proteasome 152 3.32E-4
8 SGTC_2333 9017922 3.07 200.0 µM 1.13E-4 67 0.00107
9 SGTC_736 0958-0254 3.07 92.6 µM 1.15E-4 Golgi 79 0.00108
10 SGTC_642 0335-0876 3.05 158.0 µM 1.24E-4 ubiquinone biosynthesis & proteasome 77 0.00114
11 SGTC_1270 0831-1170 2.96 17.3 µM 1.88E-4 50 0.00153
12 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 2.96 14.9 µM 1.89E-4 48 0.00154
13 SGTC_2102 5377816 2.93 72.8 µM 2.14E-4 65 0.00168
14 SGTC_2919 7978188 2.91 46.4 µM 2.34E-4 76 0.00179
15 SGTC_656 4090-1979 2.91 187.0 µM 2.35E-4 72 0.00180
16 SGTC_2347 9049783 2.76 174.8 µM 4.53E-4 105 0.00287
17 SGTC_1756 st041558 2.73 35.5 µM 5.17E-4 48 0.00315
18 SGTC_1078 idebenone 2.71 36.1 µM 5.69E-4 Golgi 131 0.00337
19 SGTC_3311 9131146 2.69 2.9 µM 6.09E-4 cell wall 206 0.00354
20 SGTC_358 0075-0058 2.69 9.4 µM 6.20E-4 172 0.00358

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.302 1.73E-71 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.258 2.86E-52 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.257 1.64E-51 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.249 1.86E-48 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.243 2.33E-46 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.224 3.04E-39 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.218 2.56E-37 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.217 6.71E-37 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.216 1.13E-36 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.214 3.88E-36 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.212 2.21E-35 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.210 7.92E-35 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.206 2.12E-33 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.201 4.76E-32 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.199 3.31E-31 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p