YMR143W / RPS16A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR143W / RPS16A

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.24|P-value:7.73E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.69|P-value:1.63E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.86|P-value:1.13E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.91|P-value:9.15E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.19|P-value:9.12E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.12|P-value:3.00E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:6.57E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:4.53|P-value:5.20E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.93|P-value:6.39E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.32|P-value:5.97E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.38|P-value:1.39E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.42|P-value:4.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.61|P-value:2.59E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.21|P-value:8.79E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.84|P-value:9.30E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.65|P-value:2.05E-8 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.94|P-value:7.76E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.25|P-value:7.56E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.20|P-value:8.65E-10 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.24|P-value:7.80E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.74|P-value:1.33E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.62|P-value:2.10E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.18|P-value:9.50E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.15|P-value:2.63E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.97|P-value:5.48E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.72|P-value:1.46E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.73|P-value:2.12E-6 ID:SGTC_2097|Compound:5376186|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.46|P-value:3.65E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.31|P-value:1.39E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.59|P-value:2.31E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.78|P-value:1.65E-6 ID:SGTC_2253|Compound:7938677|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.37|P-value:5.08E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.89|P-value:9.88E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.98|P-value:9.14E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-7.50|P-value:2.89E-13 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.96|P-value:1.01E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.25|P-value:9.77E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-4.78|P-value:2.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.25|P-value:1.70E-7 ID:SGTC_2700|Compound:st077718|FD-Score:3.93|P-value:6.54E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.34|P-value:5.61E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.25|P-value:7.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.76|P-value:1.63E-4 ID:SGTC_2904|Compound:7225135|FD-Score:-3.25|P-value:9.70E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.71|P-value:1.51E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.95|P-value:7.42E-7 ID:SGTC_2909|Compound:7941780|FD-Score:3.92|P-value:6.78E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.52|P-value:3.86E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.40|P-value:5.77E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.97|P-value:6.75E-7 ID:SGTC_3117|Compound:9124945|FD-Score:4.18|P-value:2.39E-5 ID:SGTC_3140|Compound:9094243|FD-Score:4.09|P-value:3.40E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.36|P-value:5.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.50|P-value:4.16E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.24|P-value:7.73E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.69|P-value:1.63E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.86|P-value:1.13E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.74|P-value:1.34E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.91|P-value:9.15E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.19|P-value:9.12E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:4.12|P-value:3.00E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:6.57E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:4.53|P-value:5.20E-6 ID:SGTC_625|Compound:k213-0058|FD-Score:3.93|P-value:6.39E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.32|P-value:5.97E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:-4.38|P-value:1.39E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.42|P-value:4.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:5.61|P-value:2.59E-8 ID:SGTC_942|Compound:3253-1115|FD-Score:4.33|P-value:1.23E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.21|P-value:8.79E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.84|P-value:9.30E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.65|P-value:2.05E-8 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.94|P-value:7.76E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.25|P-value:7.56E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:6.20|P-value:8.65E-10 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.24|P-value:7.80E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.17|P-value:9.75E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.74|P-value:1.33E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.62|P-value:2.10E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.18|P-value:9.50E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.15|P-value:2.63E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.97|P-value:5.48E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.72|P-value:1.46E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.73|P-value:2.12E-6 ID:SGTC_2097|Compound:5376186|FD-Score:3.41|P-value:4.45E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.46|P-value:3.65E-4 ID:SGTC_2122|Compound:5258151|FD-Score:4.31|P-value:1.39E-5 ID:SGTC_2239|Compound:6685329|FD-Score:3.59|P-value:2.31E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.78|P-value:1.65E-6 ID:SGTC_2253|Compound:7938677|FD-Score:-3.75|P-value:1.70E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.37|P-value:5.08E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.46|P-value:3.69E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.89|P-value:9.88E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-4.98|P-value:9.14E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-7.50|P-value:2.89E-13 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.96|P-value:1.01E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.25|P-value:9.77E-4 ID:SGTC_2677|Compound:mitomycin C|FD-Score:-4.78|P-value:2.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.25|P-value:1.70E-7 ID:SGTC_2700|Compound:st077718|FD-Score:3.93|P-value:6.54E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:3.34|P-value:5.61E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.25|P-value:7.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.76|P-value:1.63E-4 ID:SGTC_2904|Compound:7225135|FD-Score:-3.25|P-value:9.70E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.71|P-value:1.51E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.95|P-value:7.42E-7 ID:SGTC_2909|Compound:7941780|FD-Score:3.92|P-value:6.78E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-3.52|P-value:3.86E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.40|P-value:5.77E-4 ID:SGTC_3052|Compound:9092717|FD-Score:4.97|P-value:6.75E-7 ID:SGTC_3117|Compound:9124945|FD-Score:4.18|P-value:2.39E-5 ID:SGTC_3140|Compound:9094243|FD-Score:4.09|P-value:3.40E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-3.31|P-value:7.80E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.36|P-value:5.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.50|P-value:4.16E-4

Top fitness defect scores for YMR143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1457 k015-0032 6.20 57.3 µM 8.65E-10 5 2.77E-10
2 SGTC_1107 amlodipine 5.65 47.0 µM 2.05E-8 6 8.06E-9
3 SGTC_940 3232-1287 5.61 54.8 µM 2.59E-8 NEO1 10 1.04E-8
4 SGTC_2688 kanamycin b 5.25 96.7 µM 1.70E-7 calcium & mitochondrial duress 225 7.68E-8
5 SGTC_3052 9092717 4.97 49.5 µM 6.75E-7 12 3.33E-7
6 SGTC_2908 7930301 4.95 100.0 µM 7.42E-7 9 3.69E-7
7 SGTC_1223 0764-0573 4.94 147.0 µM 7.76E-7 6 3.87E-7
8 SGTC_2251 lansoprazole 4.78 556.0 µM 1.65E-6 10 8.63E-7
9 SGTC_1991 st073000 4.73 8.9 µM 2.12E-6 NEO1 59 1.12E-6
10 SGTC_560 2332-1943 4.53 155.0 µM 5.20E-6 2 2.92E-6
11 SGTC_942 3253-1115 4.33 227.0 µM 1.23E-5 20 7.29E-6
12 SGTC_2122 5258151 4.31 111.7 µM 1.39E-5 19 8.28E-6
13 SGTC_3117 9124945 4.18 49.5 µM 2.39E-5 2 1.48E-5
14 SGTC_1932 st074806 4.15 40.9 µM 2.63E-5 21 1.63E-5
15 SGTC_497 capsazepine 4.12 133.0 µM 3.00E-5 9 1.88E-5
16 SGTC_3140 9094243 4.09 49.5 µM 3.40E-5 21 2.15E-5
17 SGTC_1982 st072467 3.97 71.9 µM 5.48E-5 35 3.56E-5
18 SGTC_625 k213-0058 3.93 121.0 µM 6.39E-5 translation 105 4.19E-5
19 SGTC_2700 st077718 3.93 96.8 µM 6.54E-5 14 4.30E-5
20 SGTC_2909 7941780 3.92 10.5 µM 6.78E-5 20 4.47E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.25E-22 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.160 1.18E-20 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.155 1.42E-19 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.148 5.18E-18 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.139 5.23E-16 YKL143W LTV1 hom Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
0.137 1.45E-15 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.131 2.57E-14 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.131 2.65E-14 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.130 4.08E-14 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.129 6.05E-14 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.128 8.63E-14 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.127 1.47E-13 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.123 8.49E-13 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.116 1.61E-11 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.113 5.67E-11 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication