YMR147W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR147W / YMR147W

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.83|P-value:3.49E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:2.78|P-value:9.38E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.07|P-value:3.32E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.39|P-value:7.71E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.78|P-value:6.65E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.00|P-value:4.28E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.02|P-value:3.58E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.08|P-value:6.80E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.95|P-value:5.80E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.02|P-value:3.66E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.79|P-value:4.57E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:9.50|P-value:1.74E-26 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.24|P-value:1.48E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.14|P-value:2.42E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.26|P-value:1.35E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.33|P-value:1.09E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.92|P-value:5.52E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.72|P-value:6.99E-8 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.51|P-value:2.43E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.41|P-value:7.75E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.69|P-value:8.31E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:4.46|P-value:3.34E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.70|P-value:1.80E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.80|P-value:9.58E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.77|P-value:9.84E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.39|P-value:4.86E-7 ID:SGTC_2932|Compound:9016711|FD-Score:2.77|P-value:9.85E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.85|P-value:7.24E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.88|P-value:6.53E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.16|P-value:4.80E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:4.83|P-value:3.49E-8 ID:SGTC_133|Compound:0724-0033|FD-Score:2.78|P-value:9.38E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.07|P-value:3.32E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.32|P-value:1.05E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.39|P-value:7.71E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.78|P-value:6.65E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.00|P-value:4.28E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.02|P-value:3.58E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.08|P-value:6.80E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.95|P-value:5.80E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.02|P-value:3.66E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.79|P-value:4.57E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:9.50|P-value:1.74E-26 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.24|P-value:1.48E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_1902|Compound:st060212|FD-Score:-3.20|P-value:1.90E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.14|P-value:2.42E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.26|P-value:1.35E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.33|P-value:1.09E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.92|P-value:5.52E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.72|P-value:6.99E-8 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.51|P-value:2.43E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.41|P-value:7.75E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.69|P-value:8.31E-8 ID:SGTC_2620|Compound:irigenin|FD-Score:4.46|P-value:3.34E-7 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.70|P-value:1.80E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.80|P-value:9.58E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:2.77|P-value:9.84E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.39|P-value:4.86E-7 ID:SGTC_2932|Compound:9016711|FD-Score:2.77|P-value:9.85E-4 ID:SGTC_2935|Compound:9038016|FD-Score:2.85|P-value:7.24E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.88|P-value:6.53E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-5.16|P-value:4.80E-9

Top fitness defect scores for YMR147W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1179 1021-1431 9.50 9.3 µM 1.74E-26 2 1.04E-21
2 SGTC_67 0335-0847 4.83 266.0 µM 3.49E-8 ubiquinone biosynthesis & proteasome 88 6.66E-7
3 SGTC_1177 0983-0204 4.79 23.6 µM 4.57E-8 6 8.29E-7
4 SGTC_2610 ononetin 4.72 44.2 µM 6.99E-8 20 1.17E-6
5 SGTC_2616 abietic acid 4.69 100.0 µM 8.31E-8 21 1.35E-6
6 SGTC_2611 pyromycin 4.51 23.9 µM 2.43E-7 12 3.22E-6
7 SGTC_2620 irigenin 4.46 100.0 µM 3.34E-7 19 4.17E-6
8 SGTC_2816 7982706 4.39 58.4 µM 4.86E-7 azole & statin 40 5.65E-6
9 SGTC_968 1309-0633 4.02 340.0 µM 3.58E-6 11 2.86E-5
10 SGTC_2621 lithochol-11-enic acid 3.70 100.0 µM 1.80E-5 33 1.06E-4
11 SGTC_381 3461-2219 3.39 42.7 µM 7.71E-5 copper-dependent oxidative stress 35 3.49E-4
12 SGTC_378 3970-0959 3.32 8.3 µM 1.05E-4 33 4.48E-4
13 SGTC_1967 st070177 3.26 51.4 µM 1.35E-4 39 5.49E-4
14 SGTC_1219 1469-0211 3.24 33.1 µM 1.48E-4 37 5.94E-4
15 SGTC_1172 0370-0043 3.02 85.0 µM 3.66E-4 59 0.00124
16 SGTC_1842 st055362 3.00 61.2 µM 4.05E-4 55 0.00135
17 SGTC_2456 5770359 2.92 74.5 µM 5.52E-4 54 0.00174
18 SGTC_2989 9073649 2.88 71.4 µM 6.53E-4 106 0.00199
19 SGTC_2935 9038016 2.85 30.0 µM 7.24E-4 75 0.00217
20 SGTC_133 0724-0033 2.78 378.9 µM 9.38E-4 75 0.00268

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.250 8.13E-49 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.245 6.34E-47 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.244 1.11E-46 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.243 2.52E-46 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.233 1.81E-42 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.224 1.65E-39 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.216 9.16E-37 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.215 2.98E-36 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.214 5.06E-36 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.214 5.42E-36 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.209 2.05E-34 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.209 2.50E-34 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.206 1.81E-33 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.206 2.12E-33 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.205 2.48E-33 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data