YMR150C / IMP1

Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR150C / IMP1

Click on Significant Values for Screen Details ID:SGTC_134|Compound:0269-0018|FD-Score:7.09|P-value:1.11E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:3.12|P-value:3.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.12|P-value:3.92E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.98|P-value:2.08E-22 ID:SGTC_335|Compound:4077-0256|FD-Score:3.65|P-value:4.23E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:16.70|P-value:9.85E-73 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.04|P-value:5.03E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.93|P-value:1.17E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.36|P-value:1.43E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:7.30E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.45|P-value:8.27E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.03|P-value:5.28E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.10|P-value:4.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.49|P-value:2.60E-20 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:1.75E-8 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.50|P-value:6.24E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.71|P-value:3.08E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.73|P-value:2.78E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.01|P-value:6.16E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.45|P-value:9.67E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.38|P-value:1.15E-6 ID:SGTC_1563|Compound:conessine|FD-Score:3.67|P-value:4.01E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.43|P-value:6.39E-16 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.86|P-value:9.82E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.93|P-value:1.11E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:3.44E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.91|P-value:1.32E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-2.88|P-value:9.35E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.16|P-value:3.54E-6 ID:SGTC_2056|Compound:5235370|FD-Score:-5.84|P-value:1.45E-10 ID:SGTC_2103|Compound:5378138|FD-Score:4.53|P-value:5.44E-7 ID:SGTC_2165|Compound:5727197|FD-Score:-5.27|P-value:6.21E-9 ID:SGTC_2400|Compound:5203494|FD-Score:-3.66|P-value:3.83E-5 ID:SGTC_2415|Compound:st077333|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.17|P-value:3.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.11|P-value:4.13E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.87|P-value:9.57E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:5.86E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.15|P-value:4.02E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.97|P-value:4.00E-8 ID:SGTC_2839|Compound:9003951|FD-Score:2.94|P-value:7.94E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.50|P-value:7.97E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:5.35E-4 ID:SGTC_2876|Compound:9059903|FD-Score:5.83|P-value:1.74E-10 ID:SGTC_2978|Compound:9011784|FD-Score:3.47|P-value:9.35E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-4.20|P-value:2.92E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-4.26|P-value:2.08E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.90|P-value:1.38E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.00|P-value:6.34E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:7.09|P-value:1.11E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:3.12|P-value:3.99E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.12|P-value:3.92E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.98|P-value:2.08E-22 ID:SGTC_335|Compound:4077-0256|FD-Score:3.65|P-value:4.23E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:16.70|P-value:9.85E-73 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-3.04|P-value:5.03E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.18|P-value:2.94E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.93|P-value:1.17E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.36|P-value:1.43E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:7.30E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:4.45|P-value:8.27E-7 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.03|P-value:5.28E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.10|P-value:4.32E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-8.49|P-value:2.60E-20 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:1.75E-8 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.50|P-value:6.24E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.71|P-value:3.08E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.73|P-value:2.78E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.01|P-value:6.16E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.45|P-value:9.67E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.38|P-value:1.15E-6 ID:SGTC_1563|Compound:conessine|FD-Score:3.67|P-value:4.01E-5 ID:SGTC_1635|Compound:st007035|FD-Score:7.43|P-value:6.39E-16 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.86|P-value:9.82E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.93|P-value:1.11E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.14|P-value:3.44E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.91|P-value:1.32E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-2.88|P-value:9.35E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.16|P-value:3.54E-6 ID:SGTC_2056|Compound:5235370|FD-Score:-5.84|P-value:1.45E-10 ID:SGTC_2103|Compound:5378138|FD-Score:4.53|P-value:5.44E-7 ID:SGTC_2165|Compound:5727197|FD-Score:-5.27|P-value:6.21E-9 ID:SGTC_2400|Compound:5203494|FD-Score:-3.66|P-value:3.83E-5 ID:SGTC_2415|Compound:st077333|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.17|P-value:3.21E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.11|P-value:4.13E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-2.87|P-value:9.57E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:5.86E-5 ID:SGTC_2693|Compound:st077581|FD-Score:4.15|P-value:4.02E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.17|P-value:3.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.97|P-value:4.00E-8 ID:SGTC_2839|Compound:9003951|FD-Score:2.94|P-value:7.94E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.50|P-value:7.97E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:5.35E-4 ID:SGTC_2876|Compound:9059903|FD-Score:5.83|P-value:1.74E-10 ID:SGTC_2978|Compound:9011784|FD-Score:3.47|P-value:9.35E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-4.20|P-value:2.92E-6 ID:SGTC_3283|Compound:9109332|FD-Score:-4.26|P-value:2.08E-6 ID:SGTC_3294|Compound:9122953|FD-Score:-3.11|P-value:3.96E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.90|P-value:1.38E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.00|P-value:6.34E-4

Top fitness defect scores for YMR150C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_386 1509-0011 16.70 3.1 µM 9.85E-73 17 5.97E-63
2 SGTC_236 1509-0011 8.98 5.3 µM 2.08E-22 222 1.41E-19
3 SGTC_1635 st007035 7.43 42.4 µM 6.39E-16 106 5.60E-14
4 SGTC_134 0269-0018 7.09 6.9 µM 1.11E-14 65 6.60E-13
5 SGTC_2876 9059903 5.83 26.0 µM 1.74E-10 1 2.78E-9
6 SGTC_1125 tnp00248 5.12 1.3 µM 1.75E-8 9 1.50E-7
7 SGTC_2103 5378138 4.53 10.0 µM 5.44E-7 6 2.95E-6
8 SGTC_1255 0566-0045 4.50 221.0 µM 6.24E-7 excess fatty acid 20 3.32E-6
9 SGTC_802 4112-3352 4.45 742.0 µM 8.27E-7 13 4.24E-6
10 SGTC_2693 st077581 4.15 40.7 µM 4.02E-6 28 1.67E-5
11 SGTC_676 falcarinol 3.93 140.0 µM 1.17E-5 56 4.24E-5
12 SGTC_2052 5265182 3.91 7.1 µM 1.32E-5 32 4.68E-5
13 SGTC_3323 9138564 3.90 53.9 µM 1.38E-5 21 4.86E-5
14 SGTC_1563 conessine 3.67 56.1 µM 4.01E-5 21 1.23E-4
15 SGTC_335 4077-0256 3.65 27.6 µM 4.23E-5 19 1.29E-4
16 SGTC_2978 9011784 3.47 43.0 µM 9.35E-5 50 2.57E-4
17 SGTC_2564 betulinic acid 3.17 100.0 µM 3.21E-4 64 7.53E-4
18 SGTC_2751 anetholtrithion 3.17 17.2 µM 3.28E-4 59 7.67E-4
19 SGTC_168 3970-0862 3.12 530.5 µM 3.92E-4 208 8.95E-4
20 SGTC_149 3970-0822 3.12 46.1 µM 3.99E-4 tubulin folding & SWR complex 165 9.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.551 8.68E-266 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.551 1.51E-265 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.517 4.48E-229 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.514 1.70E-225 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.511 5.00E-223 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.509 6.57E-221 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.509 2.55E-220 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.500 1.95E-211 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.498 3.21E-210 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.491 1.88E-203 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.489 6.34E-201 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.487 1.32E-199 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.480 1.30E-192 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.474 2.21E-187 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.472 1.98E-185 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit