YMR151W_d / YIM2

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR151W / YIM2

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.23|P-value:3.27E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:3.49E-100 ID:SGTC_335|Compound:4077-0256|FD-Score:5.13|P-value:9.29E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:21.20|P-value:5.96E-103 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.09|P-value:9.29E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.11|P-value:7.81E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.21|P-value:5.34E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.32|P-value:5.52E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.33|P-value:3.92E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.00|P-value:2.38E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.95|P-value:2.94E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.02|P-value:1.72E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.14|P-value:1.28E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.43|P-value:2.68E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.80|P-value:5.28E-7 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.40|P-value:3.06E-4 ID:SGTC_1635|Compound:st007035|FD-Score:41.30|P-value:0 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.18|P-value:6.62E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.25|P-value:5.34E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.08|P-value:8.66E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.19|P-value:1.17E-5 ID:SGTC_2437|Compound:5741531|FD-Score:3.71|P-value:8.08E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.29|P-value:4.46E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-3.55|P-value:1.70E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.56|P-value:2.10E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.66|P-value:9.70E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:4.43|P-value:3.38E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.81|P-value:5.94E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.09|P-value:9.22E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.86|P-value:4.64E-7 ID:SGTC_2835|Compound:9006588|FD-Score:3.09|P-value:8.44E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.21|P-value:9.42E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.94|P-value:3.11E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:3.07|P-value:8.75E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.23|P-value:3.27E-17 ID:SGTC_236|Compound:1509-0011|FD-Score:20.90|P-value:3.49E-100 ID:SGTC_335|Compound:4077-0256|FD-Score:5.13|P-value:9.29E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:21.20|P-value:5.96E-103 ID:SGTC_488|Compound:nitrendipine|FD-Score:-3.09|P-value:9.29E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.11|P-value:7.81E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.21|P-value:5.34E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.32|P-value:5.52E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.33|P-value:3.92E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.00|P-value:2.38E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.95|P-value:2.94E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:5.02|P-value:1.72E-7 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.42|P-value:2.49E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:4.14|P-value:1.28E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.43|P-value:2.68E-4 ID:SGTC_1526|Compound:st051518|FD-Score:4.80|P-value:5.28E-7 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.40|P-value:3.06E-4 ID:SGTC_1635|Compound:st007035|FD-Score:41.30|P-value:0 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.18|P-value:6.62E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.25|P-value:5.34E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.08|P-value:8.66E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.19|P-value:1.17E-5 ID:SGTC_2437|Compound:5741531|FD-Score:3.71|P-value:8.08E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-5.29|P-value:4.46E-8 ID:SGTC_2478|Compound:5763493|FD-Score:-3.55|P-value:1.70E-4 ID:SGTC_2480|Compound:5767542|FD-Score:-4.56|P-value:2.10E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.66|P-value:9.70E-5 ID:SGTC_2761|Compound:levamisole|FD-Score:4.43|P-value:3.38E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.81|P-value:5.94E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.09|P-value:9.22E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.86|P-value:4.64E-7 ID:SGTC_2835|Compound:9006588|FD-Score:3.09|P-value:8.44E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.21|P-value:9.42E-6 ID:SGTC_2982|Compound:9019404|FD-Score:3.94|P-value:3.11E-5

Top fitness defect scores for YMR151W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 41.30 42.4 µM 0 1 0
2 SGTC_386 1509-0011 21.20 3.1 µM 5.96E-103 5 2.95E-100
3 SGTC_236 1509-0011 20.90 5.3 µM 3.49E-100 45 1.47E-97
4 SGTC_134 0269-0018 8.23 6.9 µM 3.27E-17 59 9.10E-17
5 SGTC_335 4077-0256 5.13 27.6 µM 9.29E-8 6 1.44E-7
6 SGTC_1247 0448-0043 5.02 5.8 µM 1.72E-7 ERG2 20 2.62E-7
7 SGTC_1526 st051518 4.80 75.0 µM 5.28E-7 8 7.80E-7
8 SGTC_2761 levamisole 4.43 97.9 µM 3.38E-6 9 4.74E-6
9 SGTC_743 1275-0778 4.32 158.0 µM 5.52E-6 excess fatty acid 27 7.64E-6
10 SGTC_2858 9025781 4.21 9.0 µM 9.42E-6 sphingolipid biosynthesis & PDR1 87 1.29E-5
11 SGTC_1336 1486-0901 4.14 104.0 µM 1.28E-5 20 1.73E-5
12 SGTC_1171 0368-0077 4.00 21.4 µM 2.38E-5 19 3.17E-5
13 SGTC_2481 5478948 3.98 45.2 µM 2.64E-5 PDR1 35 3.50E-5
14 SGTC_1214 0358-0031 3.95 63.7 µM 2.94E-5 19 3.89E-5
15 SGTC_2982 9019404 3.94 26.0 µM 3.11E-5 21 4.11E-5
16 SGTC_2437 5741531 3.71 144.2 µM 8.08E-5 42 1.04E-4
17 SGTC_2697 mebhydrolin 3.66 72.4 µM 9.70E-5 NEO1 82 1.24E-4
18 SGTC_1275 0867-0008 3.42 21.1 µM 2.49E-4 20 3.11E-4
19 SGTC_634 1611-4317 3.21 11.2 µM 5.34E-4 ERG2 40 6.52E-4
20 SGTC_511 blebbistatin 3.11 171.0 µM 7.81E-4 DNA intercalators 45 9.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.791 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.788 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.771 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.751 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.735 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.719 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.710 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.691 0 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.683 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.676 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.669 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.665 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.662 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.659 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.651 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase