HIPHOP chemogenomics database
YMR153C-A_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR153C-A deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.150 | 2.65E-18 | YML057C-A_d | YML057C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W |
| 0.128 | 1.06E-13 | YGR212W | SLI1 | hom | N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin |
| 0.121 | 2.09E-12 | YKR012C_d | YKR012C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 |
| 0.119 | 4.47E-12 | YKL072W | STB6 | hom | Protein that binds Sin3p in a two-hybrid assay |
| 0.114 | 3.81E-11 | YDR071C | PAA1 | hom | Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication |
| 0.102 | 3.31E-9 | YBR104W | YMC2 | hom | Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication |
| 0.099 | 1.03E-8 | YHR118C | ORC6 | het | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p |
| 0.098 | 1.17E-8 | YJL048C | UBX6 | hom | UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication |
| 0.095 | 3.02E-8 | YKR054C | DYN1 | hom | Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p |
| 0.095 | 3.12E-8 | YDR139C | RUB1 | hom | Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) |
| 0.088 | 3.67E-7 | YJL191W | RPS14B | hom | Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication |
| 0.087 | 4.06E-7 | YLR399C | BDF1 | hom | Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p |
| 0.086 | 5.73E-7 | YMR296C | LCB1 | het | Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
| 0.086 | 6.32E-7 | YKL144C | RPC25 | het | RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p |
| 0.085 | 8.08E-7 | YMR144W_p | YMR144W_p | hom | Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene |