YMR153C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR153C-A / YMR153C-A

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:2.97|P-value:2.24E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.41|P-value:2.91E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:2.64|P-value:8.90E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.00|P-value:2.84E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.70|P-value:9.68E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.23|P-value:5.53E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.31|P-value:7.19E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.00|P-value:2.90E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.84|P-value:3.94E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.97|P-value:2.31E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.01|P-value:1.93E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.04|P-value:2.38E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.54|P-value:1.52E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.00|P-value:2.03E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.36|P-value:3.71E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-2.73|P-value:8.68E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.76|P-value:5.65E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.10|P-value:1.27E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.01|P-value:1.91E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:2.66|P-value:8.32E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.11|P-value:6.77E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.20|P-value:8.06E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.69|P-value:7.40E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.72|P-value:6.06E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.36|P-value:1.48E-7 ID:SGTC_1686|Compound:st019653|FD-Score:2.65|P-value:8.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.68|P-value:7.59E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.14|P-value:1.07E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.42|P-value:2.78E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.16|P-value:9.94E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:2.56E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.63|P-value:1.50E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.73|P-value:8.57E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.18|P-value:1.30E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.07|P-value:8.53E-7 ID:SGTC_2073|Compound:5212005|FD-Score:4.23|P-value:3.34E-7 ID:SGTC_2140|Compound:5586273|FD-Score:-3.14|P-value:1.55E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.69|P-value:7.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.45|P-value:3.59E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.92|P-value:2.01E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-3.15|P-value:1.51E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.05|P-value:1.63E-4 ID:SGTC_2351|Compound:9026858|FD-Score:2.73|P-value:6.20E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.89|P-value:4.71E-9 ID:SGTC_2444|Compound:5485484|FD-Score:2.62|P-value:9.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:5.82|P-value:4.40E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.62|P-value:9.95E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:2.95|P-value:2.46E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.07|P-value:1.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.92|P-value:1.95E-6 ID:SGTC_2745|Compound:rifampicin|FD-Score:2.68|P-value:7.61E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.41|P-value:2.90E-5 ID:SGTC_2821|Compound:7996764|FD-Score:2.63|P-value:9.43E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-5.78|P-value:1.16E-11 ID:SGTC_2854|Compound:9024559|FD-Score:-4.69|P-value:3.21E-8 ID:SGTC_2856|Compound:9022925|FD-Score:-3.16|P-value:1.42E-4 ID:SGTC_2880|Compound:9042983|FD-Score:2.94|P-value:2.58E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.80|P-value:4.78E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.19|P-value:8.47E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.46|P-value:2.30E-5 ID:SGTC_3105|Compound:9121040|FD-Score:3.06|P-value:1.56E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.81|P-value:6.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.85|P-value:3.82E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-2.88|P-value:4.74E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.66|P-value:8.23E-6 ID:SGTC_3237|Compound:9133362|FD-Score:4.35|P-value:1.57E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:2.97|P-value:2.24E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.41|P-value:2.91E-5 ID:SGTC_287|Compound:k060-0039|FD-Score:2.64|P-value:8.90E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:-3.00|P-value:2.84E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.70|P-value:9.68E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.23|P-value:5.53E-7 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.31|P-value:7.19E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:-3.00|P-value:2.90E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.84|P-value:3.94E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.97|P-value:2.31E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.01|P-value:1.93E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.04|P-value:2.38E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.54|P-value:1.52E-5 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.00|P-value:2.03E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.36|P-value:3.71E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:-2.73|P-value:8.68E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.76|P-value:5.65E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.10|P-value:1.27E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.01|P-value:1.91E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:2.66|P-value:8.32E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.11|P-value:6.77E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.20|P-value:8.06E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.69|P-value:7.40E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.72|P-value:6.06E-6 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.36|P-value:1.48E-7 ID:SGTC_1686|Compound:st019653|FD-Score:2.65|P-value:8.82E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.68|P-value:7.59E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.14|P-value:1.07E-4 ID:SGTC_1859|Compound:st055998|FD-Score:3.42|P-value:2.78E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.16|P-value:9.94E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:2.56E-6 ID:SGTC_1930|Compound:st074634|FD-Score:-3.63|P-value:1.50E-5 ID:SGTC_1944|Compound:st076371|FD-Score:-2.73|P-value:8.57E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.18|P-value:1.30E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.07|P-value:8.53E-7 ID:SGTC_2073|Compound:5212005|FD-Score:4.23|P-value:3.34E-7 ID:SGTC_2140|Compound:5586273|FD-Score:-3.14|P-value:1.55E-4 ID:SGTC_2159|Compound:5658611|FD-Score:2.69|P-value:7.50E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.45|P-value:3.59E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.92|P-value:2.01E-6 ID:SGTC_2323|Compound:6148992|FD-Score:-3.15|P-value:1.51E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.05|P-value:1.63E-4 ID:SGTC_2351|Compound:9026858|FD-Score:2.73|P-value:6.20E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.89|P-value:4.71E-9 ID:SGTC_2444|Compound:5485484|FD-Score:2.62|P-value:9.78E-4 ID:SGTC_2450|Compound:5739737|FD-Score:5.82|P-value:4.40E-12 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:2.62|P-value:9.95E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:2.95|P-value:2.46E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.07|P-value:1.50E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.92|P-value:1.95E-6 ID:SGTC_2745|Compound:rifampicin|FD-Score:2.68|P-value:7.61E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.41|P-value:2.90E-5 ID:SGTC_2821|Compound:7996764|FD-Score:2.63|P-value:9.43E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-5.78|P-value:1.16E-11 ID:SGTC_2854|Compound:9024559|FD-Score:-4.69|P-value:3.21E-8 ID:SGTC_2856|Compound:9022925|FD-Score:-3.16|P-value:1.42E-4 ID:SGTC_2880|Compound:9042983|FD-Score:2.94|P-value:2.58E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.80|P-value:4.78E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.19|P-value:8.47E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.46|P-value:2.30E-5 ID:SGTC_3105|Compound:9121040|FD-Score:3.06|P-value:1.56E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-2.81|P-value:6.28E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.85|P-value:3.82E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-2.88|P-value:4.74E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.66|P-value:8.23E-6 ID:SGTC_3237|Compound:9133362|FD-Score:4.35|P-value:1.57E-7

Top fitness defect scores for YMR153C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2450 5739737 5.82 12.9 µM 4.40E-12 4 2.91E-9
2 SGTC_2403 6032726 4.89 181.2 µM 4.71E-9 18 5.02E-7
3 SGTC_1575 cyproterone acetate 4.36 48.0 µM 1.48E-7 12 6.42E-6
4 SGTC_3237 9133362 4.35 49.5 µM 1.57E-7 27 6.72E-6
5 SGTC_2073 5212005 4.23 126.0 µM 3.34E-7 7 1.17E-5
6 SGTC_1351 1496-0003 4.11 46.5 µM 6.77E-7 17 1.98E-5
7 SGTC_1948 st076329 4.07 66.6 µM 8.53E-7 26 2.35E-5
8 SGTC_2701 st077767 3.92 14.7 µM 1.95E-6 44 4.34E-5
9 SGTC_2318 6029776 3.92 164.0 µM 2.01E-6 32 4.43E-5
10 SGTC_1499 4480-0877 3.72 67.3 µM 6.06E-6 10 1.00E-4
11 SGTC_3236 9132701 3.66 49.5 µM 8.23E-6 TSC3-RPN4 36 1.26E-4
12 SGTC_1119 parthenolide 3.54 318.5 nM 1.52E-5 TSC3-RPN4 56 1.99E-4
13 SGTC_2988 9073640 3.46 71.4 µM 2.30E-5 31 2.70E-4
14 SGTC_1859 st055998 3.42 20.0 µM 2.78E-5 41 3.11E-4
15 SGTC_2788 5282734 3.41 71.4 µM 2.90E-5 72 3.21E-4
16 SGTC_130 0136-0219 3.41 337.7 µM 2.91E-5 41 3.21E-4
17 SGTC_1232 0279-0259 3.36 161.0 µM 3.71E-5 42 3.85E-4
18 SGTC_1363 1636-0063 3.20 10.4 µM 8.06E-5 Golgi 60 6.86E-4
19 SGTC_2936 9038235 3.19 15.6 µM 8.47E-5 57 7.12E-4
20 SGTC_1876 myriocin 3.16 605.0 nM 9.94E-5 62 8.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.65E-18 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.128 1.06E-13 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.121 2.09E-12 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.119 4.47E-12 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.114 3.81E-11 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.102 3.31E-9 YBR104W YMC2 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication
0.099 1.03E-8 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.098 1.17E-8 YJL048C UBX6 hom UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication
0.095 3.02E-8 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.095 3.12E-8 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.088 3.67E-7 YJL191W RPS14B hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication
0.087 4.06E-7 YLR399C BDF1 hom Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
0.086 5.73E-7 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.086 6.32E-7 YKL144C RPC25 het RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
0.085 8.08E-7 YMR144W_p YMR144W_p hom Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene