YMR173W / DDR48

DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR173W / DDR48

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.02|P-value:5.32E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-2.82|P-value:9.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.68|P-value:1.40E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.64|P-value:1.85E-7 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.93|P-value:6.57E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.95|P-value:6.12E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:8.60E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.49|P-value:6.43E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.14|P-value:2.84E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.35|P-value:1.20E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.69|P-value:2.63E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.17|P-value:2.59E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.97|P-value:5.66E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.36|P-value:8.99E-7 ID:SGTC_2438|Compound:5259590|FD-Score:3.02|P-value:4.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.09|P-value:3.64E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.14|P-value:2.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.01|P-value:5.53E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.84|P-value:9.37E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.86|P-value:8.57E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.10|P-value:3.59E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.48|P-value:6.72E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-3.45|P-value:7.56E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:1.92E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.72|P-value:1.14E-7 ID:SGTC_2822|Compound:7994718|FD-Score:2.88|P-value:8.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.46|P-value:1.08E-9 ID:SGTC_3197|Compound:9113331|FD-Score:3.07|P-value:3.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.27|P-value:1.70E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.02|P-value:5.32E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-2.82|P-value:9.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.68|P-value:1.40E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:-4.64|P-value:1.85E-7 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.93|P-value:6.57E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.95|P-value:6.12E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.42|P-value:8.60E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.49|P-value:6.43E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.14|P-value:2.84E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.35|P-value:1.20E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.69|P-value:2.63E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.17|P-value:2.59E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.97|P-value:5.66E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.36|P-value:8.99E-7 ID:SGTC_2438|Compound:5259590|FD-Score:3.02|P-value:4.75E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.09|P-value:3.64E-6 ID:SGTC_2505|Compound:galangin|FD-Score:-3.14|P-value:2.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.01|P-value:5.53E-6 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.84|P-value:9.37E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.86|P-value:8.57E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.10|P-value:3.59E-6 ID:SGTC_2709|Compound:st078560|FD-Score:3.48|P-value:6.72E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-3.45|P-value:7.56E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.76|P-value:1.92E-5 ID:SGTC_2821|Compound:7996764|FD-Score:4.72|P-value:1.14E-7 ID:SGTC_2822|Compound:7994718|FD-Score:2.88|P-value:8.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:5.46|P-value:1.08E-9 ID:SGTC_3197|Compound:9113331|FD-Score:3.07|P-value:3.80E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.27|P-value:1.70E-4

Top fitness defect scores for YMR173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2823 7987624 5.46 58.4 µM 1.08E-9 8 2.36E-8
2 SGTC_2821 7996764 4.72 71.4 µM 1.14E-7 18 1.16E-6
3 SGTC_2429 5902844 4.36 64.4 µM 8.99E-7 12 6.58E-6
4 SGTC_2703 st077852 4.10 53.4 µM 3.59E-6 19 2.10E-5
5 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.09 3.7 µM 3.64E-6 79 2.13E-5
6 SGTC_291 4130-1278 4.02 35.5 µM 5.32E-6 Golgi 14 2.92E-5
7 SGTC_2816 7982706 3.76 58.4 µM 1.92E-5 azole & statin 61 8.58E-5
8 SGTC_2395 5646831 3.69 180.2 µM 2.63E-5 32 1.12E-4
9 SGTC_2016 5121758 3.49 140.0 µM 6.43E-5 redox potentiating 75 2.37E-4
10 SGTC_2709 st078560 3.48 56.0 µM 6.72E-5 20 2.46E-4
11 SGTC_6 0844-0013 3.39 19.8 µM 1.02E-4 154 3.49E-4
12 SGTC_2394 5221648 3.35 200.0 µM 1.20E-4 46 4.02E-4
13 SGTC_3208 9114115 3.27 49.5 µM 1.70E-4 67 5.39E-4
14 SGTC_2425 5628681 3.17 7.8 µM 2.59E-4 67 7.67E-4
15 SGTC_3197 9113331 3.07 49.5 µM 3.80E-4 85 0.00106
16 SGTC_2404 5161160 3.04 200.0 µM 4.42E-4 62 0.00120
17 SGTC_2438 5259590 3.02 200.0 µM 4.75E-4 48 0.00128
18 SGTC_2427 5545055 2.97 42.8 µM 5.66E-4 59 0.00148
19 SGTC_1512 0259-0544 2.95 12.2 µM 6.12E-4 70 0.00158
20 SGTC_2822 7994718 2.88 71.4 µM 8.02E-4 49 0.00199

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 9.38E-46 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.213 7.97E-36 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.212 2.07E-35 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.200 1.67E-31 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.196 1.56E-30 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.190 1.61E-28 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.186 2.04E-27 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.184 7.47E-27 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.179 1.53E-25 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.178 2.76E-25 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.176 8.67E-25 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.175 1.30E-24 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.174 2.67E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.166 3.71E-22 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.163 2.77E-21 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress