YMR177W / MMT1

Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR177W / MMT1

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.71|P-value:1.31E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-4.10|P-value:2.92E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.22|P-value:7.64E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.36|P-value:6.47E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.36|P-value:4.64E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.40|P-value:4.06E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.96|P-value:4.70E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.55|P-value:2.38E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.53|P-value:2.68E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.19|P-value:8.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.00|P-value:4.00E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.18|P-value:1.71E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.76|P-value:1.06E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.31|P-value:5.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.33|P-value:5.47E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.42|P-value:3.93E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.35|P-value:4.89E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.17|P-value:1.99E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-3.29|P-value:6.31E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.70|P-value:1.41E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-4.58|P-value:3.54E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.18|P-value:9.05E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.27|P-value:1.40E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-5.28|P-value:1.08E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.08|P-value:3.09E-7 ID:SGTC_3036|Compound:9090181|FD-Score:3.23|P-value:7.25E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.71|P-value:1.31E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:-4.10|P-value:2.92E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.22|P-value:7.64E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.36|P-value:6.47E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.36|P-value:4.64E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.40|P-value:4.06E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.96|P-value:4.70E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:3.55|P-value:2.38E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.53|P-value:2.68E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.19|P-value:8.37E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.00|P-value:4.00E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.72|P-value:1.30E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:5.18|P-value:1.71E-7 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.76|P-value:1.06E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.31|P-value:5.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.33|P-value:5.47E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.42|P-value:3.93E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.35|P-value:4.89E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.17|P-value:1.99E-5 ID:SGTC_1900|Compound:st060200|FD-Score:-3.29|P-value:6.31E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.70|P-value:1.41E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-4.58|P-value:3.54E-6 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.18|P-value:9.05E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.27|P-value:1.40E-5 ID:SGTC_2625|Compound:euphol|FD-Score:-5.28|P-value:1.08E-7 ID:SGTC_2628|Compound:lathosterol|FD-Score:-5.08|P-value:3.09E-7 ID:SGTC_3036|Compound:9090181|FD-Score:3.23|P-value:7.25E-4

Top fitness defect scores for YMR177W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_367 0335-0881 5.36 7.1 µM 6.47E-8 ubiquinone biosynthesis & proteasome 32 4.12E-8
2 SGTC_1170 0310-0127 5.18 64.8 µM 1.71E-7 6 1.12E-7
3 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.17 90.6 µM 1.99E-5 30 1.52E-5
4 SGTC_1161 k007-0610 4.00 110.0 µM 4.00E-5 ERAD & cell cycle 118 3.11E-5
5 SGTC_640 3381-0960 3.96 37.1 µM 4.70E-5 12 3.68E-5
6 SGTC_1178 0988-0033 3.76 191.0 µM 1.06E-4 32 8.52E-5
7 SGTC_146 3448-8650 3.71 53.1 µM 1.31E-4 NEO1-PIK1 157 1.06E-4
8 SGTC_768 0384-0033 3.55 77.3 µM 2.38E-4 fatty acid desaturase (OLE1) 102 1.96E-4
9 SGTC_521 r062-0005 3.40 13.8 µM 4.06E-4 26 3.39E-4
10 SGTC_457 grayanotoxin iii 3.36 135.0 µM 4.64E-4 110 3.90E-4
11 SGTC_1319 1306-0155 3.35 43.7 µM 4.89E-4 57 4.11E-4
12 SGTC_1208 2323-2347 3.31 50.3 µM 5.58E-4 24 4.71E-4
13 SGTC_3036 9090181 3.23 49.5 µM 7.25E-4 16 6.17E-4
14 SGTC_365 0121-0052 3.22 13.6 µM 7.64E-4 mitochondrial response to ROS 111 6.51E-4
15 SGTC_1111 tnp00062 3.19 510.7 nM 8.37E-4 25 7.15E-4
16 SGTC_1842 st055362 3.12 61.2 µM 0.00104 44 8.93E-4
17 SGTC_1013 4112-3890 3.10 241.0 µM 0.00114 TSC3-RPN4 78 9.81E-4
18 SGTC_962 1254-0300 3.02 21.5 µM 0.00144 58 0.00125
19 SGTC_1992 st073643 2.89 23.3 µM 0.00221 mitochondrial processes 48 0.00194
20 SGTC_103 0844-0104 2.83 51.8 µM 0.00263 ERAD & cell cycle 228 0.00232

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.81E-14 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.124 5.47E-13 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.120 3.34E-12 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.115 2.03E-11 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.108 2.98E-10 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.099 9.36E-9 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.099 1.07E-8 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.095 3.31E-8 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.095 3.21E-8 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.095 4.01E-8 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.088 3.20E-7 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.088 3.39E-7 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.086 5.87E-7 YPL124W SPC29 het Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
0.083 1.35E-6 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.082 2.03E-6 YNL173C MDG1 hom Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations