HIPHOP chemogenomics database
YMR182C / RGM1 
Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR182C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.158 | 3.46E-20 | YHL006C | SHU1 | hom | Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function |
| 0.143 | 9.52E-17 | YOL064C | MET22 | hom | Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway |
| 0.120 | 3.09E-12 | YMR196W_p | YMR196W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene |
| 0.107 | 4.90E-10 | YJL125C | GCD14 | het | Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
| 0.107 | 5.27E-10 | YJL193W_p | YJL193W_p | hom | Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect |
| 0.105 | 1.03E-9 | YBR175W | SWD3 | hom | Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 |
| 0.097 | 1.92E-8 | YJR056C | YJR056C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress |
| 0.096 | 2.36E-8 | YHR077C | NMD2 | hom | Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance |
| 0.095 | 4.10E-8 | YER046W | SPO73 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis |
| 0.094 | 4.64E-8 | YHR106W | TRR2 | hom | Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication |
| 0.094 | 5.01E-8 | YOR052C | YOR052C | hom | Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress |
| 0.093 | 7.53E-8 | YJR140C | HIR3 | hom | Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein |
| 0.092 | 9.41E-8 | YKL032C | IXR1 | hom | Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b |
| 0.090 | 2.00E-7 | YNL175C | NOP13 | hom | Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress |
| 0.089 | 2.10E-7 | YKR041W | YKR041W | hom | Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking |