YMR182W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR182W-A / YMR182W-A

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-2.94|P-value:4.51E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.71|P-value:9.66E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.95|P-value:4.36E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.85|P-value:5.58E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.75|P-value:8.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.14|P-value:1.97E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.19|P-value:1.65E-9 ID:SGTC_704|Compound:1310-0270|FD-Score:2.98|P-value:3.27E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.82|P-value:6.39E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.24|P-value:1.46E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.89|P-value:5.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.29|P-value:9.80E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.01|P-value:3.33E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.87|P-value:5.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.02|P-value:3.25E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.01|P-value:3.33E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.54|P-value:2.71E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.92|P-value:4.77E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-2.81|P-value:7.43E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.11|P-value:1.39E-6 ID:SGTC_1742|Compound:st038235|FD-Score:2.76|P-value:7.86E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.40|P-value:5.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.87|P-value:5.87E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-2.83|P-value:6.91E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.24|P-value:1.09E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.92|P-value:3.78E-6 ID:SGTC_2472|Compound:5377652|FD-Score:2.86|P-value:5.37E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.76|P-value:8.15E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.57|P-value:2.33E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.71|P-value:3.98E-8 ID:SGTC_2831|Compound:7999036|FD-Score:14.90|P-value:1.42E-64 ID:SGTC_2835|Compound:9006588|FD-Score:5.16|P-value:2.07E-9 ID:SGTC_2839|Compound:9003951|FD-Score:2.92|P-value:4.24E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.70|P-value:1.40E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-3.59|P-value:2.44E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.43|P-value:2.59E-7 ID:SGTC_3001|Compound:9076041|FD-Score:3.20|P-value:1.30E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.94|P-value:4.51E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.71|P-value:9.66E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-2.95|P-value:4.36E-4 ID:SGTC_417|Compound:st075190|FD-Score:2.85|P-value:5.58E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:2.75|P-value:8.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.14|P-value:1.97E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.19|P-value:1.65E-9 ID:SGTC_704|Compound:1310-0270|FD-Score:2.98|P-value:3.27E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.82|P-value:6.39E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:-3.14|P-value:1.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.24|P-value:1.46E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.89|P-value:5.40E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.29|P-value:9.80E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.01|P-value:3.33E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.87|P-value:5.11E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.02|P-value:3.25E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.01|P-value:3.33E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.54|P-value:2.71E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.92|P-value:4.77E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:-2.81|P-value:7.43E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.11|P-value:1.39E-6 ID:SGTC_1742|Compound:st038235|FD-Score:2.76|P-value:7.86E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.40|P-value:5.18E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.87|P-value:5.87E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-2.83|P-value:6.91E-4 ID:SGTC_2158|Compound:5657123|FD-Score:3.24|P-value:1.09E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.92|P-value:3.78E-6 ID:SGTC_2472|Compound:5377652|FD-Score:2.86|P-value:5.37E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.76|P-value:8.15E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.57|P-value:2.33E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.71|P-value:3.98E-8 ID:SGTC_2831|Compound:7999036|FD-Score:14.90|P-value:1.42E-64 ID:SGTC_2835|Compound:9006588|FD-Score:5.16|P-value:2.07E-9 ID:SGTC_2839|Compound:9003951|FD-Score:2.92|P-value:4.24E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.70|P-value:1.40E-5 ID:SGTC_2969|Compound:9091408|FD-Score:-3.59|P-value:2.44E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.43|P-value:2.59E-7 ID:SGTC_3001|Compound:9076041|FD-Score:3.20|P-value:1.30E-4

Top fitness defect scores for YMR182W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2831 7999036 14.90 19.5 µM 1.42E-64 1 2.25E-50
2 SGTC_695 3505-6186 5.19 243.0 µM 1.65E-9 9 1.06E-7
3 SGTC_2835 9006588 5.16 71.4 µM 2.07E-9 16 1.26E-7
4 SGTC_2794 7785382 4.71 27.3 µM 3.98E-8 13 1.26E-6
5 SGTC_1741 st038134 4.11 10.2 µM 1.39E-6 27 2.00E-5
6 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 3.92 122.8 µM 3.78E-6 10 4.37E-5
7 SGTC_2724 maprotiline 3.57 69.6 µM 2.33E-5 ERG2 22 1.81E-4
8 SGTC_1331 1472-0049 3.54 76.2 µM 2.71E-5 35 2.04E-4
9 SGTC_1915 st067105 3.40 30.6 µM 5.18E-5 RNA pol III & RNase P/MRP 71 3.38E-4
10 SGTC_2158 5657123 3.24 3.6 µM 1.09E-4 18 6.05E-4
11 SGTC_3001 9076041 3.20 71.4 µM 1.30E-4 32 6.94E-4
12 SGTC_704 1310-0270 2.98 142.0 µM 3.27E-4 80 0.00143
13 SGTC_2839 9003951 2.92 26.0 µM 4.24E-4 53 0.00176
14 SGTC_1059 3448-6867 2.87 171.0 µM 5.11E-4 55 0.00203
15 SGTC_2472 5377652 2.86 49.4 µM 5.37E-4 TRP & mitochondrial translation 129 0.00211
16 SGTC_417 st075190 2.85 100.0 µM 5.58E-4 63 0.00218
17 SGTC_737 1950-0117 2.82 57.9 µM 6.39E-4 75 0.00242
18 SGTC_1742 st038235 2.76 28.9 µM 7.86E-4 mitochondrial stress 197 0.00285
19 SGTC_2487 5918373 2.76 44.0 µM 8.15E-4 80 0.00293
20 SGTC_431 k089-0097 2.75 107.0 µM 8.18E-4 iron homeostasis 133 0.00294

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 3.26E-35 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.199 3.41E-31 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.185 3.68E-27 YCL055W KAR4 hom Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
0.184 5.51E-27 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.181 5.09E-26 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.177 4.84E-25 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.174 2.71E-24 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.169 7.40E-23 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.160 9.55E-21 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.158 2.72E-20 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.157 5.67E-20 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.152 6.39E-19 YLR267W_p BOP2_p hom Protein of unknown function
0.148 5.81E-18 YER182W_p FMP10_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.147 8.88E-18 YJL035C TAD2 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
0.142 1.17E-16 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p