YMR183C / SSO2

Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR183C / SSO2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-3.20|P-value:4.22E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:8.33|P-value:1.08E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.16|P-value:3.49E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.19|P-value:6.18E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.66|P-value:6.77E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:-3.55|P-value:1.06E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:7.13|P-value:3.36E-14 ID:SGTC_126|Compound:0417-1624|FD-Score:4.09|P-value:8.22E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.05|P-value:5.36E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:4.84|P-value:1.73E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.50|P-value:1.14E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.03|P-value:1.11E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.57|P-value:2.29E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.26|P-value:2.90E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.29|P-value:3.07E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.57|P-value:9.87E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:3.85E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.29|P-value:3.69E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.11|P-value:5.15E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.41|P-value:1.73E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.03|P-value:6.94E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-2.99|P-value:9.04E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.00|P-value:7.72E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.01|P-value:1.38E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.47|P-value:1.47E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.58|P-value:9.43E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.79|P-value:3.20E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.09|P-value:6.44E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.26|P-value:2.99E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:6.84E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.74|P-value:3.69E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-5.89|P-value:3.64E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.16|P-value:5.86E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.72|P-value:5.08E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.06|P-value:5.04E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.05|P-value:7.35E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.07|P-value:6.89E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.64|P-value:6.37E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.32|P-value:1.08E-8 ID:SGTC_2940|Compound:9060638|FD-Score:-4.90|P-value:1.54E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-3.37|P-value:2.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.09|P-value:5.66E-4 ID:SGTC_3147|Compound:9097027|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.36|P-value:2.02E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.18|P-value:3.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-4.25|P-value:4.54E-6 ID:SGTC_3203|Compound:9113543|FD-Score:2.97|P-value:8.82E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.56|P-value:7.89E-7 ID:SGTC_3210|Compound:9128157|FD-Score:7.33|P-value:6.64E-15 ID:SGTC_3291|Compound:9121177|FD-Score:4.05|P-value:9.86E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.68|P-value:4.10E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.20|P-value:4.22E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:8.33|P-value:1.08E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.16|P-value:3.49E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.19|P-value:6.18E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.66|P-value:6.77E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:-3.55|P-value:1.06E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:7.13|P-value:3.36E-14 ID:SGTC_126|Compound:0417-1624|FD-Score:4.09|P-value:8.22E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.05|P-value:5.36E-8 ID:SGTC_161|Compound:4065-0411|FD-Score:4.84|P-value:1.73E-7 ID:SGTC_389|Compound:tpck|FD-Score:3.50|P-value:1.14E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.15|P-value:4.47E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.02|P-value:7.31E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.04|P-value:6.73E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:4.03|P-value:1.11E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.57|P-value:2.29E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.26|P-value:2.90E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.29|P-value:3.07E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.57|P-value:9.87E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:3.85E-6 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.29|P-value:3.69E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.11|P-value:5.15E-4 ID:SGTC_1653|Compound:st012112|FD-Score:4.41|P-value:1.73E-6 ID:SGTC_1655|Compound:st012546|FD-Score:3.03|P-value:6.94E-4 ID:SGTC_1690|Compound:st023502|FD-Score:-2.99|P-value:9.04E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.33|P-value:2.24E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.00|P-value:7.72E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.01|P-value:1.38E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.47|P-value:1.47E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.58|P-value:9.43E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.42|P-value:1.55E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.79|P-value:3.20E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.09|P-value:6.44E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.26|P-value:2.99E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.62|P-value:6.84E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.74|P-value:3.69E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-5.89|P-value:3.64E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.16|P-value:5.86E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.72|P-value:5.08E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.06|P-value:5.04E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.05|P-value:7.35E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.40|P-value:1.67E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-3.07|P-value:6.89E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.64|P-value:6.37E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.12|P-value:5.08E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.45|P-value:1.58E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.32|P-value:1.08E-8 ID:SGTC_2940|Compound:9060638|FD-Score:-4.90|P-value:1.54E-7 ID:SGTC_2994|Compound:9053520|FD-Score:-3.37|P-value:2.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_3105|Compound:9121040|FD-Score:3.09|P-value:5.66E-4 ID:SGTC_3147|Compound:9097027|FD-Score:2.98|P-value:8.29E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.36|P-value:2.02E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.18|P-value:3.97E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-4.25|P-value:4.54E-6 ID:SGTC_3203|Compound:9113543|FD-Score:2.97|P-value:8.82E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.56|P-value:7.89E-7 ID:SGTC_3210|Compound:9128157|FD-Score:7.33|P-value:6.64E-15 ID:SGTC_3291|Compound:9121177|FD-Score:4.05|P-value:9.86E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.68|P-value:4.10E-7

Top fitness defect scores for YMR183C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_56 0957-0365 8.33 83.2 µM 1.08E-18 Golgi 10 4.21E-17
2 SGTC_3210 9128157 7.33 49.5 µM 6.64E-15 8 1.16E-13
3 SGTC_110 0850-0284 7.13 111.6 µM 3.36E-14 2 5.08E-13
4 SGTC_878 0828-0289 5.57 13.7 µM 2.29E-9 18 1.25E-8
5 SGTC_2939 9044578 5.32 71.4 µM 1.08E-8 20 5.14E-8
6 SGTC_2689 tacrolimus 5.06 100.0 µM 5.04E-8 24 2.09E-7
7 SGTC_129 0088-0017 5.05 176.6 µM 5.36E-8 45 2.20E-7
8 SGTC_161 4065-0411 4.84 162.2 µM 1.73E-7 44 6.39E-7
9 SGTC_3303 9125618 4.68 40.6 µM 4.10E-7 28 1.40E-6
10 SGTC_3206 9114350 4.56 49.5 µM 7.89E-7 8 2.54E-6
11 SGTC_1653 st012112 4.41 65.0 µM 1.73E-6 5 5.20E-6
12 SGTC_1263 0774-1208 4.29 64.8 µM 3.07E-6 33 8.75E-6
13 SGTC_1390 3413-2614 4.25 145.0 µM 3.85E-6 fatty acid desaturase (OLE1) 20 1.07E-5
14 SGTC_2566 crystal violet carbinol 4.16 226.0 nM 5.86E-6 37 1.58E-5
15 SGTC_126 0417-1624 4.09 672.5 µM 8.22E-6 DNA intercalators 27 2.14E-5
16 SGTC_3291 9121177 4.05 71.4 µM 9.86E-6 10 2.53E-5
17 SGTC_828 2074-0507 4.03 139.0 µM 1.11E-5 RPP1 & pyrimidine depletion 22 2.81E-5
18 SGTC_1399 3562-5772 3.96 25.0 µM 1.54E-5 RPP1 & pyrimidine depletion 18 3.79E-5
19 SGTC_2057 5236571 3.79 38.3 µM 3.20E-5 RPP1 & pyrimidine depletion 37 7.38E-5
20 SGTC_2805 7950783 3.64 58.4 µM 6.37E-5 41 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.24E-16 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.134 5.76E-15 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity
0.115 2.21E-11 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.110 1.42E-10 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.106 8.35E-10 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.099 9.73E-9 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.099 1.00E-8 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.098 1.09E-8 YLR072W_p YLR072W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
0.098 1.46E-8 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.097 1.58E-8 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.096 2.69E-8 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 4.20E-8 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.094 4.31E-8 YPR153W YPR153W hom Putative protein of unknown function
0.093 6.49E-8 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.093 7.14E-8 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis