YMR187C_p

Putative protein of unknown function; YMR187C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR187C / YMR187C

Click on Significant Values for Screen Details ID:SGTC_92|Compound:0063-0024|FD-Score:3.75|P-value:6.58E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.60|P-value:1.20E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:5.46|P-value:1.21E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:3.08|P-value:8.37E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.55|P-value:1.67E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.03|P-value:9.55E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.26|P-value:8.20E-11 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.28|P-value:4.07E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:7.53E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.09|P-value:7.80E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.36|P-value:4.23E-6 ID:SGTC_1765|Compound:st044815|FD-Score:-3.78|P-value:5.29E-5 ID:SGTC_1834|Compound:st055981|FD-Score:-3.57|P-value:1.28E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.24|P-value:4.67E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.11|P-value:9.06E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.10|P-value:7.85E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.66|P-value:8.89E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.76|P-value:5.78E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.92|P-value:3.21E-5 ID:SGTC_2226|Compound:7298446|FD-Score:3.41|P-value:2.56E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.12|P-value:7.21E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.95|P-value:2.59E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.99|P-value:1.77E-7 ID:SGTC_2416|Compound:tofa|FD-Score:-3.05|P-value:8.86E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.24|P-value:4.71E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.59|P-value:1.23E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.77|P-value:5.97E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.05|P-value:9.28E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.20|P-value:5.58E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.40|P-value:2.58E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.75|P-value:6.58E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.99|P-value:2.34E-5 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.60|P-value:1.20E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:5.46|P-value:1.21E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:3.08|P-value:8.37E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:4.55|P-value:1.67E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:3.61|P-value:1.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.31|P-value:3.62E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.03|P-value:9.55E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.26|P-value:8.20E-11 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.28|P-value:4.07E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:7.53E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.22|P-value:5.19E-4 ID:SGTC_1626|Compound:st003712|FD-Score:-3.09|P-value:7.80E-4 ID:SGTC_1763|Compound:st044482|FD-Score:4.36|P-value:4.23E-6 ID:SGTC_1765|Compound:st044815|FD-Score:-3.78|P-value:5.29E-5 ID:SGTC_1834|Compound:st055981|FD-Score:-3.57|P-value:1.28E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.24|P-value:4.67E-4 ID:SGTC_1839|Compound:st053978|FD-Score:5.11|P-value:9.06E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.10|P-value:7.85E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.35|P-value:3.13E-4 ID:SGTC_2097|Compound:5376186|FD-Score:-3.66|P-value:8.89E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-3.76|P-value:5.78E-5 ID:SGTC_2215|Compound:7188065|FD-Score:3.92|P-value:3.21E-5 ID:SGTC_2226|Compound:7298446|FD-Score:3.41|P-value:2.56E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.12|P-value:7.21E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.95|P-value:2.59E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.46|P-value:2.10E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.99|P-value:1.77E-7 ID:SGTC_2416|Compound:tofa|FD-Score:-3.05|P-value:8.86E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.24|P-value:4.71E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.59|P-value:1.23E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.43|P-value:2.33E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.77|P-value:5.97E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.05|P-value:9.28E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.20|P-value:5.58E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.40|P-value:2.58E-4

Top fitness defect scores for YMR187C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1035 k081-0041 6.26 55.2 µM 8.20E-11 Golgi 2 1.94E-10
2 SGTC_711 k292-0785 5.46 179.0 µM 1.21E-8 DNA intercalators 6 2.33E-8
3 SGTC_1839 st053978 5.11 48.0 µM 9.06E-8 7 1.61E-7
4 SGTC_2369 9071472 4.99 200.0 µM 1.77E-7 7 3.06E-7
5 SGTC_772 k072-0172 4.55 35.3 µM 1.67E-6 8 2.64E-6
6 SGTC_1763 st044482 4.36 94.5 µM 4.23E-6 copper-dependent oxidative stress 17 6.42E-6
7 SGTC_1032 k061-1018 4.01 98.7 µM 2.09E-5 19 2.97E-5
8 SGTC_95 0471-0001 3.99 561.1 µM 2.34E-5 25 3.32E-5
9 SGTC_2215 7188065 3.92 200.0 µM 3.21E-5 6 4.50E-5
10 SGTC_2902 5787006 3.77 60.5 µM 5.97E-5 Golgi 31 8.16E-5
11 SGTC_92 0063-0024 3.75 660.9 µM 6.58E-5 17 8.96E-5
12 SGTC_1247 0448-0043 3.71 5.8 µM 7.53E-5 ERG2 56 1.02E-4
13 SGTC_784 4579-0127 3.61 173.0 µM 1.16E-4 35 1.55E-4
14 SGTC_120 rhodamine 6G 3.60 52.3 µM 1.20E-4 mitochondrial processes 46 1.60E-4
15 SGTC_2611 pyromycin 3.59 23.9 µM 1.23E-4 46 1.63E-4
16 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.51 92.6 µM 1.68E-4 38 2.20E-4
17 SGTC_2365 9042475 3.46 200.0 µM 2.10E-4 61 2.73E-4
18 SGTC_2729 fluphenazine 3.43 10.7 µM 2.33E-4 29 3.02E-4
19 SGTC_653 0203-0016 3.41 55.2 µM 2.50E-4 36 3.23E-4
20 SGTC_2226 7298446 3.41 200.0 µM 2.56E-4 7 3.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 2.05E-10 YGR198W YPP1 het Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
0.095 3.16E-8 YHR160C PEX18 hom Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
0.094 5.67E-8 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
0.089 2.22E-7 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.087 5.20E-7 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.079 4.50E-6 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
0.078 6.75E-6 YAL019W FUN30 hom Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate
0.077 8.33E-6 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.077 8.41E-6 YPR076W_d YPR076W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 9.87E-6 YDR102C_d YDR102C_d hom Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
0.075 1.38E-5 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.074 1.81E-5 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.074 1.92E-5 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.073 2.24E-5 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.073 2.24E-5 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene