YMR188C / MRPS17

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR188C / MRPS17

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.46|P-value:3.21E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.14|P-value:2.29E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.52|P-value:3.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.37|P-value:6.23E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.02|P-value:3.75E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.12|P-value:2.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.18|P-value:9.79E-20 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.75|P-value:1.82E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.19|P-value:8.35E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.49|P-value:3.48E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.17|P-value:8.88E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.18|P-value:2.32E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.89|P-value:7.48E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.43|P-value:3.65E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.31|P-value:5.47E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.90|P-value:7.45E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.44|P-value:3.48E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:5.62|P-value:1.68E-8 ID:SGTC_967|Compound:1306-0166|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.63|P-value:1.75E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:7.88|P-value:5.04E-15 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.15|P-value:2.16E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.08|P-value:2.91E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:5.10|P-value:2.63E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.21|P-value:7.77E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.19|P-value:1.81E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.19|P-value:8.18E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.97|P-value:5.06E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.84|P-value:1.17E-6 ID:SGTC_1861|Compound:st057647|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.98|P-value:5.24E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.70|P-value:1.34E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.70|P-value:1.31E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.65|P-value:1.94E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.56|P-value:3.58E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.38|P-value:4.25E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.94|P-value:3.32E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.67|P-value:2.62E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.52|P-value:4.38E-6 ID:SGTC_2816|Compound:7982706|FD-Score:10.20|P-value:9.06E-24 ID:SGTC_2825|Compound:7998094|FD-Score:11.00|P-value:2.23E-27 ID:SGTC_2826|Compound:7992541|FD-Score:6.81|P-value:1.09E-11 ID:SGTC_2828|Compound:7998861|FD-Score:4.42|P-value:6.69E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.72|P-value:1.23E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.05|P-value:3.30E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.64|P-value:1.89E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.81|P-value:8.83E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.81|P-value:8.78E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.61|P-value:1.85E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.46|P-value:3.21E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.14|P-value:2.29E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.52|P-value:3.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.37|P-value:6.23E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:4.02|P-value:3.75E-5 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.12|P-value:2.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.18|P-value:9.79E-20 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.75|P-value:1.82E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.74|P-value:1.15E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:3.19|P-value:8.35E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.49|P-value:3.48E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.17|P-value:8.88E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.18|P-value:2.32E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.89|P-value:7.48E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.43|P-value:3.65E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.31|P-value:5.47E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.90|P-value:7.45E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.44|P-value:3.48E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:5.62|P-value:1.68E-8 ID:SGTC_967|Compound:1306-0166|FD-Score:4.13|P-value:2.37E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.63|P-value:1.75E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:7.88|P-value:5.04E-15 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.15|P-value:2.16E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.64|P-value:1.67E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.08|P-value:2.91E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:5.10|P-value:2.63E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.91|P-value:5.85E-5 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.65|P-value:1.87E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.21|P-value:7.77E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.19|P-value:1.81E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.31|P-value:5.48E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.19|P-value:8.18E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:4.97|P-value:5.06E-7 ID:SGTC_1621|Compound:st003705|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.79|P-value:1.13E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.84|P-value:1.17E-6 ID:SGTC_1861|Compound:st057647|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_2015|Compound:5119600|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.81|P-value:8.68E-5 ID:SGTC_2157|Compound:5649910|FD-Score:-3.98|P-value:5.24E-5 ID:SGTC_2241|Compound:6772625|FD-Score:3.70|P-value:1.34E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.70|P-value:1.31E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.65|P-value:1.94E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.56|P-value:3.58E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.38|P-value:4.25E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.94|P-value:3.32E-9 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.67|P-value:2.62E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.52|P-value:4.38E-6 ID:SGTC_2816|Compound:7982706|FD-Score:10.20|P-value:9.06E-24 ID:SGTC_2825|Compound:7998094|FD-Score:11.00|P-value:2.23E-27 ID:SGTC_2826|Compound:7992541|FD-Score:6.81|P-value:1.09E-11 ID:SGTC_2828|Compound:7998861|FD-Score:4.42|P-value:6.69E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.72|P-value:1.23E-4 ID:SGTC_2870|Compound:9038528|FD-Score:5.05|P-value:3.30E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.64|P-value:1.89E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.34|P-value:4.94E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.81|P-value:8.83E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.81|P-value:8.78E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.28|P-value:5.99E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.61|P-value:1.85E-4

Top fitness defect scores for YMR188C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2825 7998094 11.00 58.4 µM 2.23E-27 fatty acid desaturase (OLE1) 3 2.38E-28
2 SGTC_2816 7982706 10.20 58.4 µM 9.06E-24 azole & statin 4 1.35E-24
3 SGTC_310 1273-0058 9.18 1.1 µM 9.79E-20 mitochondrial stress 61 2.11E-20
4 SGTC_1093 fluphenazine 7.88 8.0 µM 5.04E-15 1 1.66E-15
5 SGTC_2826 7992541 6.81 19.5 µM 1.09E-11 1 4.85E-12
6 SGTC_933 2914-0560 5.62 114.0 µM 1.68E-8 11 9.82E-9
7 SGTC_173 1273-0061 5.37 2.7 µM 6.23E-8 mitochondrial stress 131 3.83E-8
8 SGTC_1145 3546-0597 5.10 10.2 µM 2.63E-7 mitochondrial processes 7 1.71E-7
9 SGTC_2870 9038528 5.05 13.0 µM 3.30E-7 8 2.16E-7
10 SGTC_1461 k072-0203 4.97 53.8 µM 5.06E-7 2 3.36E-7
11 SGTC_2467 5474540 4.56 200.0 µM 3.58E-6 7 2.56E-6
12 SGTC_2804 7954240 4.52 19.5 µM 4.38E-6 24 3.14E-6
13 SGTC_2828 7998861 4.42 71.4 µM 6.69E-6 8 4.88E-6
14 SGTC_1341 1486-1360 4.19 280.0 µM 1.81E-5 19 1.37E-5
15 SGTC_1116 jasmonic acid 4.15 1.6 µM 2.16E-5 20 1.64E-5
16 SGTC_63 0099-0242 4.14 26.7 µM 2.29E-5 mitochondrial stress 79 1.75E-5
17 SGTC_967 1306-0166 4.13 352.0 µM 2.37E-5 28 1.81E-5
18 SGTC_275 trichlorophene 4.12 5.7 µM 2.48E-5 mitochondrial stress 219 1.90E-5
19 SGTC_1133 3473-0247 4.08 50.0 µM 2.91E-5 RSC complex & mRNA processing 42 2.24E-5
20 SGTC_236 1509-0011 4.02 5.3 µM 3.75E-5 380 2.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 1.43E-82 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.306 8.24E-74 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.306 1.29E-73 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.298 1.56E-69 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.297 3.85E-69 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.295 2.32E-68 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.295 3.92E-68 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.293 1.92E-67 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.290 1.04E-65 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.276 1.86E-59 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.273 1.56E-58 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.273 2.10E-58 YDR332W IRC3 hom Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.273 2.30E-58 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.271 1.56E-57 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.271 1.96E-57 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene