HIPHOP chemogenomics database

YMR188C / MRPS17

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR188C / MRPS17

Click on Significant Values for Screen Details

Top fitness defect scores for YMR188C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2825	7998094	11.00	58.4 µM	2.23E-27	fatty acid desaturase (OLE1)	3	2.38E-28
2	SGTC_2816	7982706	10.20	58.4 µM	9.06E-24	azole & statin	4	1.35E-24
3	SGTC_310	1273-0058	9.18	1.1 µM	9.79E-20	mitochondrial stress	61	2.11E-20
4	SGTC_1093	fluphenazine	7.88	8.0 µM	5.04E-15		1	1.66E-15
5	SGTC_2826	7992541	6.81	19.5 µM	1.09E-11		1	4.85E-12
6	SGTC_933	2914-0560	5.62	114.0 µM	1.68E-8		11	9.82E-9
7	SGTC_173	1273-0061	5.37	2.7 µM	6.23E-8	mitochondrial stress	131	3.83E-8
8	SGTC_1145	3546-0597	5.10	10.2 µM	2.63E-7	mitochondrial processes	7	1.71E-7
9	SGTC_2870	9038528	5.05	13.0 µM	3.30E-7		8	2.16E-7
10	SGTC_1461	k072-0203	4.97	53.8 µM	5.06E-7		2	3.36E-7
11	SGTC_2467	5474540	4.56	200.0 µM	3.58E-6		7	2.56E-6
12	SGTC_2804	7954240	4.52	19.5 µM	4.38E-6		24	3.14E-6
13	SGTC_2828	7998861	4.42	71.4 µM	6.69E-6		8	4.88E-6
14	SGTC_1341	1486-1360	4.19	280.0 µM	1.81E-5		19	1.37E-5
15	SGTC_1116	jasmonic acid	4.15	1.6 µM	2.16E-5		20	1.64E-5
16	SGTC_63	0099-0242	4.14	26.7 µM	2.29E-5	mitochondrial stress	79	1.75E-5
17	SGTC_967	1306-0166	4.13	352.0 µM	2.37E-5		28	1.81E-5
18	SGTC_275	trichlorophene	4.12	5.7 µM	2.48E-5	mitochondrial stress	219	1.90E-5
19	SGTC_1133	3473-0247	4.08	50.0 µM	2.91E-5	RSC complex & mRNA processing	42	2.24E-5
20	SGTC_236	1509-0011	4.02	5.3 µM	3.75E-5		380	2.90E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.324	1.43E-82	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.306	8.24E-74	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.306	1.29E-73	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.298	1.56E-69	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.297	3.85E-69	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.295	2.32E-68	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.295	3.92E-68	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.293	1.92E-67	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.290	1.04E-65	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.276	1.86E-59	YML061C	PIF1	hom	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.273	1.56E-58	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.273	2.10E-58	YDR332W	IRC3	hom	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.273	2.30E-58	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.271	1.56E-57	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.271	1.96E-57	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene