YMR208W / ERG12

Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR208W / ERG12

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:4.34|P-value:1.10E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:8.14|P-value:2.12E-12 ID:SGTC_113|Compound:0099-0221|FD-Score:3.80|P-value:6.16E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.93|P-value:4.19E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:8.30|P-value:8.03E-13 ID:SGTC_126|Compound:0417-1624|FD-Score:7.78|P-value:1.82E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.60|P-value:4.44E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.92|P-value:1.43E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.04|P-value:2.98E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.61|P-value:9.02E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.72|P-value:2.96E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.43|P-value:8.07E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.83|P-value:5.55E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.58|P-value:4.93E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:5.58|P-value:1.04E-6 ID:SGTC_398|Compound:bronopol|FD-Score:4.12|P-value:2.25E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:6.65|P-value:7.75E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.79|P-value:2.29E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.84|P-value:1.94E-5 ID:SGTC_469|Compound:w7|FD-Score:5.99|P-value:1.72E-7 ID:SGTC_470|Compound:aa-861|FD-Score:10.70|P-value:3.35E-20 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:10.70|P-value:4.82E-20 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.63|P-value:9.85E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.85|P-value:5.26E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.41|P-value:2.07E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:2.75E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.52|P-value:7.84E-11 ID:SGTC_679|Compound:0422-0091|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.11|P-value:2.39E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:6.94|P-value:1.78E-9 ID:SGTC_858|Compound:0438-0351|FD-Score:3.78|P-value:6.57E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:6.04|P-value:1.39E-7 ID:SGTC_872|Compound:0588-0139|FD-Score:3.82|P-value:5.82E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.29|P-value:1.30E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.05|P-value:2.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.88|P-value:4.87E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.25|P-value:1.51E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.24|P-value:1.55E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:7.18|P-value:5.00E-10 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.31|P-value:1.22E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.43|P-value:8.32E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.85|P-value:1.85E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.33|P-value:2.90E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:16.10|P-value:2.82E-43 ID:SGTC_1460|Compound:k062-0059|FD-Score:7.51|P-value:8.26E-11 ID:SGTC_1461|Compound:k072-0203|FD-Score:5.08|P-value:7.83E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:11.60|P-value:1.97E-23 ID:SGTC_1522|Compound:st012842|FD-Score:4.84|P-value:1.94E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.38|P-value:9.51E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.19|P-value:1.80E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-4.62|P-value:4.10E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.03|P-value:3.07E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.73|P-value:7.58E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.24|P-value:1.52E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.01|P-value:3.24E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.93|P-value:1.88E-9 ID:SGTC_1927|Compound:st060202|FD-Score:-4.53|P-value:5.63E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.92|P-value:4.28E-4 ID:SGTC_2000|Compound:st075254|FD-Score:5.61|P-value:9.20E-7 ID:SGTC_2098|Compound:5376439|FD-Score:5.52|P-value:1.30E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.55|P-value:5.38E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.12|P-value:2.28E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.01|P-value:3.27E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.21|P-value:4.15E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.81|P-value:5.89E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.77|P-value:2.43E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-4.32|P-value:1.19E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.57|P-value:1.06E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-6.29|P-value:4.30E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.66|P-value:9.29E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.77|P-value:2.51E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.46|P-value:7.16E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.98|P-value:1.12E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.78|P-value:6.51E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.93|P-value:4.12E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.12|P-value:2.30E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.65|P-value:9.38E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.81|P-value:5.84E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.55|P-value:5.26E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-4.08|P-value:2.53E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.61|P-value:4.42E-5 ID:SGTC_2949|Compound:9072542|FD-Score:7.03|P-value:1.08E-9 ID:SGTC_2953|Compound:9074162|FD-Score:3.74|P-value:7.28E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.07|P-value:2.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.76|P-value:4.67E-7 ID:SGTC_3036|Compound:9090181|FD-Score:3.73|P-value:7.62E-4 ID:SGTC_3040|Compound:9091894|FD-Score:10.00|P-value:6.17E-18 ID:SGTC_3043|Compound:9092303|FD-Score:3.67|P-value:9.00E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.76|P-value:2.58E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.80|P-value:6.05E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.74|P-value:7.39E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.79|P-value:2.33E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:4.34|P-value:1.10E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:8.14|P-value:2.12E-12 ID:SGTC_113|Compound:0099-0221|FD-Score:3.80|P-value:6.16E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.93|P-value:4.19E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:8.30|P-value:8.03E-13 ID:SGTC_126|Compound:0417-1624|FD-Score:7.78|P-value:1.82E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.60|P-value:4.44E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.92|P-value:1.43E-5 ID:SGTC_144|Compound:4161-2749|FD-Score:4.04|P-value:2.98E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.61|P-value:9.02E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:4.72|P-value:2.96E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.43|P-value:8.07E-5 ID:SGTC_202|Compound:3594-0513|FD-Score:3.83|P-value:5.55E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.58|P-value:4.93E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:5.58|P-value:1.04E-6 ID:SGTC_398|Compound:bronopol|FD-Score:4.12|P-value:2.25E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:6.65|P-value:7.75E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.79|P-value:2.29E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.84|P-value:1.94E-5 ID:SGTC_469|Compound:w7|FD-Score:5.99|P-value:1.72E-7 ID:SGTC_470|Compound:aa-861|FD-Score:10.70|P-value:3.35E-20 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:10.70|P-value:4.82E-20 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.63|P-value:9.85E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.85|P-value:5.26E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.41|P-value:2.07E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:4.06|P-value:2.75E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:7.52|P-value:7.84E-11 ID:SGTC_679|Compound:0422-0091|FD-Score:3.90|P-value:4.54E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.11|P-value:2.39E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:6.94|P-value:1.78E-9 ID:SGTC_858|Compound:0438-0351|FD-Score:3.78|P-value:6.57E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:6.04|P-value:1.39E-7 ID:SGTC_872|Compound:0588-0139|FD-Score:3.82|P-value:5.82E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.29|P-value:1.30E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:4.05|P-value:2.89E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.88|P-value:4.87E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.25|P-value:1.51E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.24|P-value:1.55E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:7.18|P-value:5.00E-10 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.31|P-value:1.22E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:4.43|P-value:8.32E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.85|P-value:1.85E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:5.33|P-value:2.90E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:16.10|P-value:2.82E-43 ID:SGTC_1460|Compound:k062-0059|FD-Score:7.51|P-value:8.26E-11 ID:SGTC_1461|Compound:k072-0203|FD-Score:5.08|P-value:7.83E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:11.60|P-value:1.97E-23 ID:SGTC_1522|Compound:st012842|FD-Score:4.84|P-value:1.94E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-4.38|P-value:9.51E-5 ID:SGTC_1629|Compound:st005085|FD-Score:4.19|P-value:1.80E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-4.62|P-value:4.10E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.03|P-value:3.07E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.73|P-value:7.58E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.24|P-value:1.52E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.01|P-value:3.24E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.93|P-value:1.88E-9 ID:SGTC_1927|Compound:st060202|FD-Score:-4.53|P-value:5.63E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.92|P-value:4.28E-4 ID:SGTC_2000|Compound:st075254|FD-Score:5.61|P-value:9.20E-7 ID:SGTC_2098|Compound:5376439|FD-Score:5.52|P-value:1.30E-6 ID:SGTC_2128|Compound:5255449|FD-Score:4.55|P-value:5.38E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.12|P-value:2.28E-4 ID:SGTC_2181|Compound:6316240|FD-Score:4.01|P-value:3.27E-4 ID:SGTC_2248|Compound:tofa|FD-Score:7.21|P-value:4.15E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.81|P-value:5.89E-4 ID:SGTC_2436|Compound:5633522|FD-Score:4.77|P-value:2.43E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-4.32|P-value:1.19E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.57|P-value:1.06E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-6.29|P-value:4.30E-8 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.66|P-value:9.29E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.77|P-value:2.51E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:-4.46|P-value:7.16E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.98|P-value:1.12E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.78|P-value:6.51E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.93|P-value:4.12E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.12|P-value:2.30E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.65|P-value:9.38E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-3.81|P-value:5.84E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.55|P-value:5.26E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-4.08|P-value:2.53E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.61|P-value:4.42E-5 ID:SGTC_2949|Compound:9072542|FD-Score:7.03|P-value:1.08E-9 ID:SGTC_2953|Compound:9074162|FD-Score:3.74|P-value:7.28E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.07|P-value:2.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.76|P-value:4.67E-7 ID:SGTC_3036|Compound:9090181|FD-Score:3.73|P-value:7.62E-4 ID:SGTC_3040|Compound:9091894|FD-Score:10.00|P-value:6.17E-18 ID:SGTC_3043|Compound:9092303|FD-Score:3.67|P-value:9.00E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.76|P-value:2.58E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.80|P-value:6.05E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.74|P-value:7.39E-4 ID:SGTC_3321|Compound:9137793|FD-Score:4.79|P-value:2.33E-5

Top fitness defect scores for YMR208W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1459 k035-0031 16.10 35.7 µM 2.82E-43 DNA intercalators 1 6.07E-59 9.75
2 SGTC_1465 k213-0056 11.60 144.0 µM 1.97E-23 DNA intercalators 1 1.32E-31 6.03
3 SGTC_470 aa-861 10.70 153.0 µM 3.35E-20 sphingolipid biosynthesis & PDR1 1 3.68E-27 3.19
4 SGTC_471 1-acyl-paf 10.70 4.0 µM 4.82E-20 DNA intercalators 1 6.07E-27 1.71
5 SGTC_3040 9091894 10.00 49.5 µM 6.17E-18 DNA intercalators 1 4.80E-24 4.17
6 SGTC_125 0133-0007 8.30 11.8 µM 8.03E-13 DNA intercalators 1 5.14E-17 3.01
7 SGTC_106 0092-0003 8.14 11.6 µM 2.12E-12 copper-dependent oxidative stress 2 1.95E-16 1.49
8 SGTC_126 0417-1624 7.78 672.5 µM 1.82E-11 DNA intercalators 3 3.73E-15 1.48
9 SGTC_633 0437-0093 7.52 97.7 µM 7.84E-11 DNA intercalators 2 2.77E-14 1.57
10 SGTC_1460 k062-0059 7.51 9.2 µM 8.26E-11 Golgi 1 2.97E-14 2.98
11 SGTC_2248 tofa 7.21 1.1 µM 4.15E-10 sphingolipid biosynthesis & PDR1 10 2.72E-13 0.15
12 SGTC_1290 0986-0249 7.18 10.2 µM 5.00E-10 DNA intercalators 1 3.51E-13 1.24
13 SGTC_2949 9072542 7.03 2.2 µM 1.08E-9 TSC3-RPN4 1 1.01E-12 0.86
14 SGTC_711 k292-0785 6.94 179.0 µM 1.78E-9 DNA intercalators 1 2.00E-12 1.76
15 SGTC_1926 methyl fluorone black 6.93 53.6 µM 1.88E-9 DNA intercalators 7 2.16E-12 0.12
16 SGTC_412 gemfibrozil 6.65 100.0 µM 7.75E-9 DNA intercalators 1 1.50E-11 1.26
17 SGTC_867 0518-0118 6.04 155.0 µM 1.39E-7 DNA intercalators 5 7.82E-10 0.18
18 SGTC_469 w7 5.99 172.0 µM 1.72E-7 ERG2 1 1.05E-9 1.12
19 SGTC_3020 9089140 5.76 49.5 µM 4.67E-7 2 4.11E-9 0.55
20 SGTC_145 3737-0113 5.61 38.4 µM 9.02E-7 DNA intercalators 22 1.01E-8 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.386 1.23E-119 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.357 2.45E-101 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.346 4.43E-95 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.332 3.68E-87 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.327 5.29E-84 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.290 6.09E-66 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.286 4.66E-64 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.281 1.07E-61 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.268 2.79E-56 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.261 3.64E-53 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.253 3.16E-50 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.246 2.33E-47 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.239 7.82E-45 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.226 5.28E-40 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.223 3.67E-39 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm