YMR210W

Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR210W / YMR210W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.13|P-value:3.15E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.30|P-value:1.74E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:4.39|P-value:4.72E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:2.86|P-value:6.79E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.18|P-value:1.85E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.67|P-value:1.44E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:2.93|P-value:5.09E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.87|P-value:6.56E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.07|P-value:2.94E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.90|P-value:7.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.16|P-value:1.98E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.19|P-value:2.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.53|P-value:6.09E-10 ID:SGTC_884|Compound:0851-0618|FD-Score:2.88|P-value:6.18E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.83|P-value:7.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.94|P-value:7.90E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.84|P-value:9.77E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.52|P-value:4.10E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.20|P-value:2.31E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.77|P-value:9.47E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.68|P-value:1.94E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.46|P-value:5.37E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.92|P-value:7.15E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.95|P-value:6.23E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-2.87|P-value:8.66E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.02|P-value:4.83E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.13|P-value:3.05E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.88|P-value:8.38E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.15|P-value:1.81E-6 ID:SGTC_2372|Compound:9071633|FD-Score:3.49|P-value:4.73E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.97|P-value:4.38E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.44|P-value:6.56E-10 ID:SGTC_2625|Compound:euphol|FD-Score:2.83|P-value:7.68E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.90|P-value:7.71E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.80|P-value:8.61E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.00|P-value:5.25E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.13|P-value:3.15E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.30|P-value:1.74E-9 ID:SGTC_41|Compound:0478-0632|FD-Score:4.39|P-value:4.72E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:2.86|P-value:6.79E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.18|P-value:1.85E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-4.67|P-value:1.44E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:2.93|P-value:5.09E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:2.87|P-value:6.56E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.07|P-value:2.94E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-2.90|P-value:7.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.16|P-value:1.98E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.19|P-value:2.37E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.53|P-value:6.09E-10 ID:SGTC_884|Compound:0851-0618|FD-Score:2.88|P-value:6.18E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:2.83|P-value:7.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.94|P-value:7.90E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.84|P-value:9.77E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.52|P-value:4.10E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.20|P-value:2.31E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:2.77|P-value:9.47E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.68|P-value:1.94E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.46|P-value:5.37E-5 ID:SGTC_1415|Compound:3966-0071|FD-Score:-2.92|P-value:7.15E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.19|P-value:2.38E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-2.95|P-value:6.23E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-2.87|P-value:8.66E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.02|P-value:4.83E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.13|P-value:3.05E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.88|P-value:8.38E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.15|P-value:1.81E-6 ID:SGTC_2372|Compound:9071633|FD-Score:3.49|P-value:4.73E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.97|P-value:4.38E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:5.44|P-value:6.56E-10 ID:SGTC_2625|Compound:euphol|FD-Score:2.83|P-value:7.68E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-2.90|P-value:7.71E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.80|P-value:8.61E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.00|P-value:5.25E-4

Top fitness defect scores for YMR210W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2621 lithochol-11-enic acid 5.44 100.0 µM 6.56E-10 5 2.60E-8
2 SGTC_39 0986-0283 5.30 58.4 µM 1.74E-9 calcium & mitochondrial duress 12 5.76E-8
3 SGTC_41 0478-0632 4.39 82.6 µM 4.72E-7 20 5.57E-6
4 SGTC_2370 9071495 4.15 200.0 µM 1.81E-6 mitochondrial processes 24 1.67E-5
5 SGTC_1382 3002-2117 3.68 298.0 µM 1.94E-5 16 1.16E-4
6 SGTC_1270 0831-1170 3.52 17.3 µM 4.10E-5 19 2.14E-4
7 SGTC_2372 9071633 3.49 200.0 µM 4.73E-5 19 2.41E-4
8 SGTC_1384 3089-0840 3.46 101.0 µM 5.37E-5 26 2.67E-4
9 SGTC_130 0136-0219 3.18 337.7 µM 1.85E-4 54 7.34E-4
10 SGTC_475 α-linolenic acid 3.16 10.0 µM 1.98E-4 excess fatty acid 46 7.76E-4
11 SGTC_367 0335-0881 3.07 7.1 µM 2.94E-4 ubiquinone biosynthesis & proteasome 134 0.00107
12 SGTC_2374 9071832 2.97 200.0 µM 4.38E-4 endomembrane recycling 35 0.00149
13 SGTC_345 1362-0200 2.93 395.0 µM 5.09E-4 63 0.00169
14 SGTC_884 0851-0618 2.88 334.0 µM 6.18E-4 67 0.00197
15 SGTC_350 k064-0020 2.87 19.8 µM 6.56E-4 heme requiring 82 0.00207
16 SGTC_73 0327-0325 2.86 16.2 µM 6.79E-4 DNA damage response 136 0.00213
17 SGTC_988 1497-1057 2.83 103.0 µM 7.42E-4 49 0.00229
18 SGTC_2625 euphol 2.83 100.0 µM 7.68E-4 104 0.00236
19 SGTC_2692 st077426 2.80 47.7 µM 8.61E-4 86 0.00259
20 SGTC_2103 5378138 2.78 10.0 µM 8.97E-4 79 0.00268

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 6.48E-109 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.276 1.14E-59 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.273 3.34E-58 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.268 4.30E-56 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.264 1.86E-54 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.262 1.05E-53 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.261 2.66E-53 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.260 6.56E-53 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.245 3.21E-47 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.232 2.12E-42 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.232 3.07E-42 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.224 2.13E-39 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.216 1.02E-36 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.212 1.44E-35 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.210 6.93E-35 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential