HIPHOP chemogenomics database
YMR213W / CEF1 
Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YMR213W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.182 | 1.80E-26 | YBR207W | FTH1 | hom | Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress |
| 0.177 | 6.54E-25 | YBR199W | KTR4 | hom | Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family |
| 0.176 | 8.73E-25 | YMR105C | PGM2 | hom | Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress |
| 0.159 | 2.39E-20 | YOR287C | RRP36 | het | Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit |
| 0.154 | 2.42E-19 | YDR191W | HST4 | hom | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| 0.146 | 2.42E-17 | YNL129W | NRK1 | hom | Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis |
| 0.141 | 1.89E-16 | YDR330W | UBX5 | hom | UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p |
| 0.138 | 8.84E-16 | YNL103W | MET4 | het | Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p |
| 0.133 | 8.58E-15 | YNR044W | AGA1 | hom | Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds |
| 0.133 | 1.02E-14 | YBL019W | APN2 | hom | Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII |
| 0.132 | 1.78E-14 | YEL004W | YEA4 | hom | Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER |
| 0.121 | 2.31E-12 | YGL249W | ZIP2 | hom | Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
| 0.121 | 2.36E-12 | YOR010C | TIR2 | hom | Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis |
| 0.118 | 6.19E-12 | YOL078W | AVO1 | het | Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth |
| 0.117 | 1.04E-11 | YDR133C_d | YDR133C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C |