HIPHOP chemogenomics database

YMR214W / SCJ1

One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR214W / SCJ1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR214W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_453	enantio-paf c16	16.20	10.0 µM	5.66E-52		1	5.41E-59
2	SGTC_2582	agaric acid	13.00	100.0 µM	1.34E-34	redox potentiating	28	3.50E-39
3	SGTC_568	1193-0097	8.16	7.5 µM	1.04E-14	ERAD & cell cycle	33	1.62E-16
4	SGTC_2896	9052656	8.16	71.4 µM	1.11E-14	endomembrane recycling	16	1.73E-16
5	SGTC_58	0957-0393	7.12	9.0 µM	1.27E-11	cell wall	160	5.26E-13
6	SGTC_8	0354-0001	6.76	70.0 µM	1.19E-10		20	6.74E-12
7	SGTC_59	0330-0160	6.48	1.3 µM	6.37E-10		29	4.53E-11
8	SGTC_2586	curcumin	6.27	80.0 µM	2.09E-9	iron homeostasis	12	1.75E-10
9	SGTC_124	0136-0217	6.18	7.1 µM	3.51E-9	mitochondrial stress	23	3.15E-10
10	SGTC_178	4092-0806	5.89	87.5 µM	1.71E-8	ergosterol depletion effects on membrane	42	1.90E-9
11	SGTC_2396	5342950	5.83	42.8 µM	2.35E-8	RSC complex & mRNA processing	15	2.74E-9
12	SGTC_116	0155-0182	5.58	31.8 µM	8.48E-8	mitochondrial response to ROS	31	1.18E-8
13	SGTC_1425	4048-4433	5.57	7.3 µM	9.10E-8	copper-dependent oxidative stress	13	1.28E-8
14	SGTC_1658	st012944	5.18	20.0 µM	6.08E-7	iron homeostasis	43	1.10E-7
15	SGTC_1750	st081859	5.17	2.4 µM	6.40E-7	endomembrane recycling	133	1.17E-7
16	SGTC_268	camptothecin	5.08	39.6 µM	9.87E-7	DNA damage response	46	1.91E-7
17	SGTC_3200	9114385	5.05	49.5 µM	1.11E-6		13	2.19E-7
18	SGTC_3334	9142812	5.00	21.9 µM	1.41E-6		13	2.87E-7
19	SGTC_3142	9086498	4.90	49.5 µM	2.20E-6	iron homeostasis	20	4.74E-7
20	SGTC_207	4185-0010	4.89	4.5 µM	2.34E-6	endomembrane recycling	56	5.09E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.331	1.65E-86	YML101C-A_d	YML101C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.304	6.26E-73	YOR034C-A_p	YOR034C-A_p	hom	Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.260	4.31E-53	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.258	2.87E-52	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.248	4.12E-48	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.246	2.72E-47	YGL178W	MPT5	hom	mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.241	1.62E-45	YML102W	CAC2	hom	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.234	6.66E-43	YKL121W_p	DGR2_p	hom	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds
0.228	6.11E-41	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.215	2.49E-36	YDR435C	PPM1	hom	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.198	4.62E-31	YDL173W	PAR32	hom	Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.193	1.38E-29	YER072W	VTC1	hom	Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.190	1.09E-28	YNL215W	IES2	hom	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.190	1.32E-28	YEL042W	GDA1	hom	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.189	1.89E-28	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels