YMR225C / MRPL44

Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR225C / MRPL44

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.72|P-value:5.94E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.24|P-value:4.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:2.60E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.68|P-value:6.51E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.94|P-value:2.47E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.17|P-value:5.55E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.54|P-value:1.16E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.22|P-value:4.01E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.57|P-value:1.28E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.95|P-value:1.70E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.04|P-value:8.90E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.33|P-value:3.05E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.10|P-value:7.23E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.46|P-value:2.18E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.93|P-value:2.61E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.45|P-value:1.91E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.02|P-value:8.39E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.76|P-value:5.51E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.29|P-value:5.09E-6 ID:SGTC_1995|Compound:st072814|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.02|P-value:1.79E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.25|P-value:3.53E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.07|P-value:7.98E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:8.42E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.94|P-value:2.51E-5 ID:SGTC_2681|Compound:menadione|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.42|P-value:1.85E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.21|P-value:4.88E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.17|P-value:8.94E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-4.02|P-value:1.49E-5 ID:SGTC_3003|Compound:9075612|FD-Score:5.47|P-value:8.61E-9 ID:SGTC_3020|Compound:9089140|FD-Score:-3.71|P-value:5.78E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.93|P-value:2.61E-5 ID:SGTC_3076|Compound:9116187|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_3168|Compound:9103419|FD-Score:-3.04|P-value:7.78E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:4.40E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.36|P-value:2.33E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.72|P-value:5.94E-7 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.22|P-value:3.96E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.24|P-value:4.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:2.60E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.68|P-value:6.51E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.94|P-value:2.47E-5 ID:SGTC_348|Compound:k064-0012|FD-Score:3.17|P-value:5.55E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.54|P-value:1.16E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:-3.22|P-value:4.01E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.57|P-value:1.28E-6 ID:SGTC_576|Compound:1073-0113|FD-Score:4.95|P-value:1.70E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.04|P-value:8.90E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.33|P-value:3.05E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.10|P-value:7.23E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.46|P-value:2.18E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:4.11|P-value:1.16E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.93|P-value:2.61E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.45|P-value:1.91E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.02|P-value:8.39E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.76|P-value:5.51E-5 ID:SGTC_1738|Compound:st035555|FD-Score:4.29|P-value:5.09E-6 ID:SGTC_1995|Compound:st072814|FD-Score:3.05|P-value:8.67E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.50|P-value:1.58E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.02|P-value:1.79E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.24|P-value:4.34E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.25|P-value:3.53E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.07|P-value:7.98E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.06|P-value:8.25E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:8.42E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.94|P-value:2.51E-5 ID:SGTC_2681|Compound:menadione|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.42|P-value:1.85E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.32|P-value:3.25E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.21|P-value:4.88E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.17|P-value:8.94E-6 ID:SGTC_2841|Compound:9004761|FD-Score:3.95|P-value:2.42E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.47|P-value:1.51E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-4.02|P-value:1.49E-5 ID:SGTC_3003|Compound:9075612|FD-Score:5.47|P-value:8.61E-9 ID:SGTC_3020|Compound:9089140|FD-Score:-3.71|P-value:5.78E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.93|P-value:2.61E-5 ID:SGTC_3076|Compound:9116187|FD-Score:3.47|P-value:1.82E-4 ID:SGTC_3168|Compound:9103419|FD-Score:-3.04|P-value:7.78E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.77|P-value:4.40E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.36|P-value:2.33E-4

Top fitness defect scores for YMR225C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3003 9075612 5.47 71.4 µM 8.61E-9 5 2.24E-8
2 SGTC_576 1073-0113 4.95 22.7 µM 1.70E-7 redox potentiating 34 3.69E-7
3 SGTC_20 0481-0013 4.72 4.9 µM 5.94E-7 11 1.20E-6
4 SGTC_486 niguldipine 4.57 82.0 µM 1.28E-6 amide catabolism 11 2.47E-6
5 SGTC_1175 0741-0056 4.46 27.6 µM 2.18E-6 7 4.08E-6
6 SGTC_1738 st035555 4.29 74.0 µM 5.09E-6 TSC3-RPN4 23 9.06E-6
7 SGTC_2812 7970281 4.17 58.4 µM 8.94E-6 22 1.54E-5
8 SGTC_1207 2099-0101 4.11 141.0 µM 1.16E-5 16 1.97E-5
9 SGTC_2321 7390090 4.02 138.8 µM 1.79E-5 24 2.96E-5
10 SGTC_259 usnic acid 3.97 108.9 µM 2.24E-5 17 3.65E-5
11 SGTC_2841 9004761 3.95 39.0 µM 2.42E-5 amide catabolism 29 3.93E-5
12 SGTC_276 colchicine 3.94 750.0 µM 2.47E-5 19 4.02E-5
13 SGTC_2595 hexamethylquercetagetin 3.94 100.0 µM 2.51E-5 25 4.08E-5
14 SGTC_3054 9094397 3.93 49.5 µM 2.61E-5 fatty acid desaturase (OLE1) 31 4.22E-5
15 SGTC_1350 1495-0454 3.93 146.0 µM 2.61E-5 30 4.22E-5
16 SGTC_1655 st012546 3.76 55.1 µM 5.51E-5 34 8.54E-5
17 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.66 63.6 µM 8.42E-5 56 1.27E-4
18 SGTC_2080 5212524 3.55 12.4 µM 1.30E-4 copper-dependent oxidative stress 24 1.92E-4
19 SGTC_2129 girgensonine 3.50 121.0 µM 1.58E-4 heme biosynthesis & mitochondrial translocase 50 2.31E-4
20 SGTC_3076 9116187 3.47 49.5 µM 1.82E-4 24 2.63E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.17E-25 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.095 3.12E-8 YKR056W TRM2 hom tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
0.092 1.03E-7 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.09E-7 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.084 1.26E-6 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.083 1.47E-6 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.083 1.61E-6 YOR120W GCY1 hom Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication
0.076 9.52E-6 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.075 1.46E-5 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.071 3.68E-5 YCR090C_p YCR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
0.071 3.73E-5 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.067 1.13E-4 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.066 1.22E-4 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.066 1.22E-4 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.066 1.36E-4 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally