YMR235C / RNA1

GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR235C / RNA1

Click on Significant Values for Screen Details ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.10|P-value:2.97E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.24|P-value:1.84E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.95|P-value:7.08E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.21|P-value:2.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.17|P-value:2.25E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.96|P-value:5.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.15|P-value:2.66E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.98|P-value:5.30E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:7.05E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.20|P-value:2.20E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.58|P-value:4.09E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.49|P-value:6.32E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.89|P-value:6.77E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.82|P-value:9.72E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.39|P-value:9.70E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.95|P-value:7.06E-6 ID:SGTC_1690|Compound:st023502|FD-Score:3.14|P-value:2.75E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-2.98|P-value:4.82E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:4.31E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.96|P-value:5.76E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.58|P-value:3.59E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-3.12|P-value:2.73E-4 ID:SGTC_2172|Compound:5754775|FD-Score:2.86|P-value:8.22E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.46|P-value:7.20E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.33|P-value:1.26E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.30|P-value:1.29E-4 ID:SGTC_2319|Compound:6033012|FD-Score:2.98|P-value:5.21E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-2.82|P-value:8.97E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.47|P-value:4.21E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-3.75|P-value:1.63E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.65|P-value:2.98E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-2.82|P-value:8.98E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.84|P-value:5.11E-8 ID:SGTC_2692|Compound:st077426|FD-Score:5.18|P-value:5.82E-9 ID:SGTC_2696|Compound:st077691|FD-Score:6.34|P-value:1.45E-12 ID:SGTC_2821|Compound:7996764|FD-Score:-3.53|P-value:4.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.70|P-value:2.04E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.18|P-value:2.15E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.99|P-value:5.62E-6 ID:SGTC_3199|Compound:9111318|FD-Score:4.21|P-value:1.82E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-3.07|P-value:3.34E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.83|P-value:1.26E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.10|P-value:2.97E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.24|P-value:1.84E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.95|P-value:7.08E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.21|P-value:2.07E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.17|P-value:2.25E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.96|P-value:5.26E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.15|P-value:2.66E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:2.98|P-value:5.30E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:2.90|P-value:7.05E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.20|P-value:2.20E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.58|P-value:4.09E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.30|P-value:1.44E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.49|P-value:6.32E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-2.89|P-value:6.77E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:2.82|P-value:9.72E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.39|P-value:9.70E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:3.95|P-value:7.06E-6 ID:SGTC_1690|Compound:st023502|FD-Score:3.14|P-value:2.75E-4 ID:SGTC_1703|Compound:st026983|FD-Score:-2.98|P-value:4.82E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:4.31E-5 ID:SGTC_1758|Compound:st042942|FD-Score:2.96|P-value:5.76E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.58|P-value:3.59E-5 ID:SGTC_1904|Compound:st060225|FD-Score:-3.12|P-value:2.73E-4 ID:SGTC_2172|Compound:5754775|FD-Score:2.86|P-value:8.22E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.46|P-value:7.20E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.33|P-value:1.26E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.30|P-value:1.29E-4 ID:SGTC_2319|Compound:6033012|FD-Score:2.98|P-value:5.21E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-2.82|P-value:8.97E-4 ID:SGTC_2382|Compound:9035899|FD-Score:4.47|P-value:4.21E-7 ID:SGTC_2388|Compound:9080168|FD-Score:-3.75|P-value:1.63E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.65|P-value:2.98E-5 ID:SGTC_2474|Compound:5321570|FD-Score:-2.82|P-value:8.98E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:4.84|P-value:5.11E-8 ID:SGTC_2692|Compound:st077426|FD-Score:5.18|P-value:5.82E-9 ID:SGTC_2696|Compound:st077691|FD-Score:6.34|P-value:1.45E-12 ID:SGTC_2821|Compound:7996764|FD-Score:-3.53|P-value:4.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.70|P-value:2.04E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-3.18|P-value:2.15E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.99|P-value:5.62E-6 ID:SGTC_3199|Compound:9111318|FD-Score:4.21|P-value:1.82E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-3.07|P-value:3.34E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.83|P-value:1.26E-5

Top fitness defect scores for YMR235C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2696 st077691 6.34 74.3 µM 1.45E-12 3 1.16E-10 0.01
2 SGTC_2692 st077426 5.18 47.7 µM 5.82E-9 2 1.10E-7 0.63
3 SGTC_2649 anisomycin 4.84 9.6 µM 5.11E-8 2 6.66E-7 0.63
4 SGTC_2382 9035899 4.47 200.0 µM 4.21E-7 60S ribosome export 4 3.82E-6 0.23
5 SGTC_3199 9111318 4.21 49.5 µM 1.82E-6 9 1.29E-5 0.02
6 SGTC_3194 9111903 3.99 49.5 µM 5.62E-6 4 3.28E-5 0.50
7 SGTC_1568 digitonin 3.95 820.0 nM 7.06E-6 sphingolipid biosynthesis & PDR1 15 3.96E-5 0.03
8 SGTC_369 0957-0393 3.95 4.5 µM 7.08E-6 cell wall signaling 8 3.98E-5 0.05
9 SGTC_3333 9141820 3.83 12.1 µM 1.26E-5 6 6.41E-5 0.00
10 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.65 200.0 µM 2.98E-5 6 1.31E-4 0.02
11 SGTC_875 0709-0210 3.58 25.7 µM 4.09E-5 fatty acid desaturase (OLE1) 14 1.71E-4 0.12
12 SGTC_1704 st028805 3.57 70.8 µM 4.31E-5 8 1.79E-4 0.26
13 SGTC_1128 3448-9350 3.49 235.0 µM 6.32E-5 8 2.46E-4 0.05
14 SGTC_2285 7945142 3.46 200.0 µM 7.20E-5 13 2.74E-4 0.02
15 SGTC_1522 st012842 3.39 45.6 µM 9.70E-5 RNA pol III & RNase P/MRP 18 3.51E-4 0.01
16 SGTC_2303 7774051 3.33 200.0 µM 1.26E-4 14 4.37E-4 0.03
17 SGTC_973 1325-0077 3.30 65.9 µM 1.44E-4 6 4.87E-4 0.40
18 SGTC_259 usnic acid 3.24 108.9 µM 1.84E-4 15 5.97E-4 0.13
19 SGTC_493 zm226600 3.21 134.0 µM 2.07E-4 mitochondrial processes 13 6.60E-4 0.04
20 SGTC_817 1391-0715 3.20 46.0 µM 2.20E-4 17 6.93E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 1.04E-12 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.121 2.02E-12 YPL233W NSL1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.115 2.90E-11 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.110 2.04E-10 YDR190C RVB1 het ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.106 6.17E-10 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.106 7.71E-10 YJL133W MRS3 hom Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication
0.102 3.80E-9 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.100 5.80E-9 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.092 1.01E-7 YGR282C BGL2 hom Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
0.089 2.61E-7 YOR063W RPL3 het Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
0.087 4.08E-7 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.087 4.76E-7 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.081 2.39E-6 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.081 2.47E-6 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.080 3.33E-6 YER027C GAL83 hom One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain