HIPHOP chemogenomics database
YMR253C_p 
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR253C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.161 | 5.42E-21 | YPL236C | ENV7 | hom | Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) |
| 0.141 | 2.18E-16 | YJL034W | KAR2 | het | ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p |
| 0.129 | 6.25E-14 | YLL058W_p | YLL058W_p | hom | Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene |
| 0.125 | 4.12E-13 | YOR032C | HMS1 | hom | Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant |
| 0.124 | 5.67E-13 | YGR267C | FOL2 | het | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
| 0.114 | 4.12E-11 | YLR097C | HRT3 | hom | Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies |
| 0.110 | 1.95E-10 | YGR133W | PEX4 | hom | Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis |
| 0.109 | 2.15E-10 | YMR283C | RIT1 | hom | 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA |
| 0.109 | 2.11E-10 | YHR103W | SBE22 | hom | Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth |
| 0.102 | 3.43E-9 | YGR247W | CPD1 | hom | Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress |
| 0.102 | 3.84E-9 | YGR256W | GND2 | hom | 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication |
| 0.101 | 5.29E-9 | YEL051W | VMA8 | hom | Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis |
| 0.101 | 5.36E-9 | YMR002W | MIC17 | hom | Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress |
| 0.100 | 6.13E-9 | YBL043W | ECM13 | hom | Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication |
| 0.099 | 7.85E-9 | YGR238C | KEL2 | hom | Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate |