YMR254C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR254C / YMR254C

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.74|P-value:5.58E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.46|P-value:7.45E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.26|P-value:3.49E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.06|P-value:8.01E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.65|P-value:8.31E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.24|P-value:3.79E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.28|P-value:3.55E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.61|P-value:9.67E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.81|P-value:3.76E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.52|P-value:1.40E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.36|P-value:1.48E-8 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:5.84E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.86|P-value:3.28E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.68|P-value:6.56E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.40|P-value:2.21E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.77|P-value:4.10E-7 ID:SGTC_1749|Compound:st037932|FD-Score:3.83|P-value:3.86E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.63|P-value:9.00E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:3.36E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.24|P-value:4.10E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.39|P-value:2.35E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.11|P-value:6.28E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.47|P-value:1.68E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.28|P-value:3.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.69|P-value:6.43E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.26|P-value:3.77E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.35|P-value:2.54E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.74|P-value:5.58E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-5.46|P-value:7.45E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:-3.26|P-value:3.49E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.06|P-value:8.01E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.65|P-value:8.31E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.67|P-value:7.36E-5 ID:SGTC_456|Compound:gingerol|FD-Score:-3.24|P-value:3.79E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.28|P-value:3.55E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.61|P-value:9.67E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:-3.81|P-value:3.76E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.16|P-value:5.21E-4 ID:SGTC_597|Compound:k018-0003|FD-Score:3.52|P-value:1.40E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.36|P-value:1.48E-8 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.14|P-value:5.84E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.86|P-value:3.28E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.57|P-value:1.03E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-3.68|P-value:6.56E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.40|P-value:2.21E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.77|P-value:4.10E-7 ID:SGTC_1749|Compound:st037932|FD-Score:3.83|P-value:3.86E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.63|P-value:9.00E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.29|P-value:3.36E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.24|P-value:4.10E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.53|P-value:1.36E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.39|P-value:2.35E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.11|P-value:6.28E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.47|P-value:1.68E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.28|P-value:3.47E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-3.69|P-value:6.43E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.58|P-value:1.09E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.26|P-value:3.77E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.35|P-value:2.54E-4

Top fitness defect scores for YMR254C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1135 dihydrocapsaicin 5.36 536.7 nM 1.48E-8 11 4.10E-8
2 SGTC_1680 diphenhydramine 4.77 100.0 µM 4.10E-7 NEO1 14 9.19E-7
3 SGTC_1508 1080-0625 3.86 72.9 µM 3.28E-5 20 5.58E-5
4 SGTC_1749 st037932 3.83 54.2 µM 3.86E-5 31 6.51E-5
5 SGTC_136 0097-0015 3.74 404.5 µM 5.58E-5 60S ribosome export 20 9.19E-5
6 SGTC_430 0958-0115 3.67 16.4 µM 7.36E-5 33 1.19E-4
7 SGTC_278 4092-0821 3.65 23.9 µM 8.31E-5 plasma membrane duress 51 1.33E-4
8 SGTC_2004 4023728 3.63 41.9 µM 9.00E-5 35 1.44E-4
9 SGTC_525 k781-2675 3.61 26.7 µM 9.67E-5 redox potentiating 63 1.54E-4
10 SGTC_3020 9089140 3.58 49.5 µM 1.09E-4 36 1.72E-4
11 SGTC_2823 7987624 3.57 58.4 µM 1.15E-4 46 1.81E-4
12 SGTC_2401 5128683 3.53 200.0 µM 1.36E-4 55 2.11E-4
13 SGTC_597 k018-0003 3.52 82.8 µM 1.40E-4 RNA pol III & RNase P/MRP 20 2.18E-4
14 SGTC_2629 bisabolol 3.47 100.0 µM 1.68E-4 35 2.58E-4
15 SGTC_1376 2910-0861 3.44 41.3 µM 1.92E-4 37 2.93E-4
16 SGTC_1673 st016611 3.40 27.3 µM 2.21E-4 67 3.34E-4
17 SGTC_2501 sodium tetradecyl sulfate 3.39 13.4 µM 2.35E-4 54 3.54E-4
18 SGTC_2053 5265679 3.29 138.0 µM 3.36E-4 51 4.94E-4
19 SGTC_2852 9023854 3.28 52.0 µM 3.47E-4 47 5.11E-4
20 SGTC_491 tetrandrine 3.28 80.3 µM 3.55E-4 25 5.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.14E-11 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.112 6.64E-11 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.108 3.88E-10 YFR053C HXK1 hom Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication
0.106 7.25E-10 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
0.106 8.33E-10 YDR481C PHO8 hom Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
0.104 1.65E-9 YJR031C GEA1 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.098 1.15E-8 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.086 6.63E-7 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.95E-6 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.079 4.90E-6 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.079 5.24E-6 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.078 6.79E-6 YJR062C NTA1 hom Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
0.073 2.11E-5 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.073 2.64E-5 YDR264C AKR1 hom Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication
0.072 2.96E-5 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing