YMR257C / PET111

Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR257C / PET111

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.55E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.49|P-value:8.54E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.16|P-value:2.05E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:12.50|P-value:2.18E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:6.82E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.49|P-value:4.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:1.22E-22 ID:SGTC_314|Compound:1671-0008|FD-Score:5.64|P-value:2.11E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.12|P-value:2.15E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.30|P-value:6.29E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.09|P-value:2.27E-16 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.57|P-value:7.39E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.19|P-value:8.22E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.25|P-value:6.72E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.95|P-value:4.41E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:4.11|P-value:1.09E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.44|P-value:9.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.08|P-value:1.21E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.15|P-value:9.49E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.92|P-value:5.04E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.54|P-value:7.36E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.37|P-value:4.37E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.15|P-value:1.88E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.66|P-value:4.98E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.32|P-value:5.26E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.23|P-value:1.31E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.59|P-value:6.18E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.02|P-value:1.70E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.96|P-value:1.85E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.80|P-value:3.16E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.01|P-value:1.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.39|P-value:6.59E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:5.30E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.49|P-value:8.51E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.14|P-value:1.12E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.13|P-value:1.16E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.65|P-value:1.50E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.46|P-value:9.40E-4 ID:SGTC_2096|Compound:5468907|FD-Score:-3.50|P-value:9.23E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.70|P-value:4.44E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.65|P-value:1.49E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.21|P-value:7.76E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.87|P-value:6.16E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.27|P-value:1.09E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.06|P-value:1.30E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.85|P-value:2.68E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.72|P-value:4.14E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.63|P-value:5.44E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.89|P-value:2.38E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.04|P-value:3.00E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.43|P-value:3.46E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.02|P-value:1.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.22|P-value:1.63E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-4.65|P-value:1.65E-5 ID:SGTC_3177|Compound:9107506|FD-Score:-3.69|P-value:5.04E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.27|P-value:7.13E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.97|P-value:1.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.89|P-value:2.60E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.87|P-value:2.55E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.49|P-value:8.54E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.16|P-value:2.05E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:12.50|P-value:2.18E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:6.82E-25 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.49|P-value:4.13E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:10.80|P-value:1.22E-22 ID:SGTC_314|Compound:1671-0008|FD-Score:5.64|P-value:2.11E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.12|P-value:2.15E-6 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.30|P-value:6.29E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-9.09|P-value:2.27E-16 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.57|P-value:7.39E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.19|P-value:8.22E-5 ID:SGTC_652|Compound:0437-0092|FD-Score:4.25|P-value:6.72E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.95|P-value:4.41E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:4.11|P-value:1.09E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.44|P-value:9.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.08|P-value:1.21E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.15|P-value:9.49E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:4.92|P-value:5.04E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.54|P-value:7.36E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:4.37|P-value:4.37E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.15|P-value:1.88E-6 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.66|P-value:4.98E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.32|P-value:5.26E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.23|P-value:1.31E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.59|P-value:6.18E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-4.02|P-value:1.70E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.96|P-value:1.85E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.80|P-value:3.16E-4 ID:SGTC_1666|Compound:st014829|FD-Score:4.01|P-value:1.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.39|P-value:6.59E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.67|P-value:5.30E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.49|P-value:8.51E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.14|P-value:1.12E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.13|P-value:1.16E-4 ID:SGTC_2078|Compound:5212016|FD-Score:4.65|P-value:1.50E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.46|P-value:9.40E-4 ID:SGTC_2096|Compound:5468907|FD-Score:-3.50|P-value:9.23E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.70|P-value:4.44E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.65|P-value:1.49E-5 ID:SGTC_2194|Compound:5927483|FD-Score:4.21|P-value:7.76E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.87|P-value:6.16E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.95|P-value:1.91E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.27|P-value:1.09E-6 ID:SGTC_2254|Compound:7938975|FD-Score:4.06|P-value:1.30E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.85|P-value:2.68E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.72|P-value:4.14E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.63|P-value:5.44E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.89|P-value:2.38E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.04|P-value:3.00E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.43|P-value:3.46E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.02|P-value:1.68E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.22|P-value:1.63E-6 ID:SGTC_2908|Compound:7930301|FD-Score:-4.65|P-value:1.65E-5 ID:SGTC_3177|Compound:9107506|FD-Score:-3.69|P-value:5.04E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.27|P-value:7.13E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.97|P-value:1.98E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.89|P-value:2.60E-4

Top fitness defect scores for YMR257C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 12.50 2.7 µM 2.18E-29 mitochondrial stress 20 4.31E-36
2 SGTC_236 1509-0011 11.40 5.3 µM 6.82E-25 161 1.69E-30
3 SGTC_310 1273-0058 10.80 1.1 µM 1.22E-22 mitochondrial stress 31 1.07E-27
4 SGTC_314 1671-0008 5.64 2.7 µM 2.11E-7 11 8.75E-9
5 SGTC_275 trichlorophene 5.49 5.7 µM 4.13E-7 mitochondrial stress 138 2.01E-8
6 SGTC_1742 st038235 5.39 28.9 µM 6.59E-7 mitochondrial stress 63 3.59E-8
7 SGTC_2250 alverine citrate 5.27 130.0 µM 1.09E-6 85 6.65E-8
8 SGTC_1394 3474-0001 5.23 65.7 µM 1.31E-6 endomembrane recycling 19 8.40E-8
9 SGTC_1130 3454-2858 5.15 15.9 µM 1.88E-6 NEO1 56 1.31E-7
10 SGTC_421 streptovitacin 5.12 30.0 mM 2.15E-6 5 1.54E-7
11 SGTC_2589 lobaric acid 5.04 100.0 µM 3.00E-6 12 2.33E-7
12 SGTC_704 1310-0270 4.95 142.0 µM 4.41E-6 16 3.75E-7
13 SGTC_908 3448-7491 4.92 47.7 µM 5.04E-6 mitochondrial stress 80 4.42E-7
14 SGTC_2232 chlorophetanol 4.87 41.5 µM 6.16E-6 TRP & mitochondrial translation 85 5.66E-7
15 SGTC_2183 6420625 4.65 130.5 µM 1.49E-5 mitochondrial processes 35 1.68E-6
16 SGTC_2078 5212016 4.65 200.0 µM 1.50E-5 60S ribosome export 6 1.69E-6
17 SGTC_2688 kanamycin b 4.43 96.7 µM 3.46E-5 calcium & mitochondrial duress 300 4.74E-6
18 SGTC_1123 mangostin 4.37 811.3 nM 4.37E-5 mitochondrial response to ROS 28 6.32E-6
19 SGTC_1371 2421-0008 4.32 32.7 µM 5.26E-5 mitochondrial processes 24 7.95E-6
20 SGTC_652 0437-0092 4.25 114.0 µM 6.72E-5 5 1.07E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.459 2.39E-174 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.455 5.19E-171 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.442 3.57E-160 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.440 7.05E-158 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.431 9.17E-152 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.421 3.31E-144 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.420 6.02E-144 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.418 1.04E-141 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.417 1.37E-141 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.415 4.96E-140 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.405 1.09E-132 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.405 2.76E-132 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.404 7.58E-132 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.401 5.47E-130 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.401 8.20E-130 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function