HIPHOP chemogenomics database

YMR262W_p

Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR262W / YMR262W

Click on Significant Values for Screen Details

Top fitness defect scores for YMR262W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_264	promethazine	10.10	12.5 mM	1.66E-25	DNA intercalators	10	1.90E-24
2	SGTC_145	3737-0113	8.16	38.4 µM	3.33E-17	DNA intercalators	7	1.66E-16
3	SGTC_588	3970-1144	7.24	52.9 µM	6.08E-14		3	2.19E-13
4	SGTC_126	0417-1624	7.24	672.5 µM	6.44E-14	DNA intercalators	1	2.31E-13
5	SGTC_577	r071-0003	6.93	38.6 µM	6.33E-13	fatty acid desaturase (OLE1)	8	2.06E-12
6	SGTC_2834	9001755	6.52	58.4 µM	1.21E-11		8	3.46E-11
7	SGTC_144	4161-2749	6.49	112.4 µM	1.55E-11	DNA intercalators	6	4.38E-11
8	SGTC_1926	methyl fluorone black	6.08	53.6 µM	2.45E-10	DNA intercalators	19	6.14E-10
9	SGTC_3040	9091894	5.93	49.5 µM	6.49E-10	DNA intercalators	9	1.56E-9
10	SGTC_585	0kpi-0023	5.69	191.0 µM	2.74E-9		6	6.19E-9
11	SGTC_112	phenothiazine	5.60	287.2 µM	4.77E-9	unfolded protein response	5	1.05E-8
12	SGTC_1337	1486-1011	4.92	40.3 µM	2.34E-7		4	4.35E-7
13	SGTC_219	mitoxanthrone	4.53	164.4 µM	1.71E-6	DNA intercalators	38	2.93E-6
14	SGTC_1750	st081859	4.38	2.4 µM	3.59E-6	endomembrane recycling	159	5.95E-6
15	SGTC_2628	lathosterol	4.37	100.0 µM	3.83E-6		22	6.32E-6
16	SGTC_2757	clomiphene	4.33	4.2 µM	4.58E-6	fatty acid desaturase (OLE1)	27	7.50E-6
17	SGTC_2884	9058502	4.26	52.0 µM	6.31E-6		22	1.02E-5
18	SGTC_579	4491-1009	4.23	110.0 µM	7.15E-6	60S ribosome export	17	1.15E-5
19	SGTC_663	1486-0733	3.82	13.9 µM	4.52E-5	cell wall signaling	55	6.70E-5
20	SGTC_2906	7926292	3.73	26.4 µM	6.55E-5		31	9.56E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.430	7.14E-151	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.410	4.04E-136	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.396	2.57E-126	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.383	1.06E-117	YMR166C_p	YMR166C_p	hom	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.344	8.07E-94	YMR289W	ABZ2	hom	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.329	2.71E-85	YOR133W	EFT1	hom	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.289	2.69E-65	YGR065C	VHT1	het	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.286	3.80E-64	YDL223C	HBT1	hom	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.282	2.86E-62	YEL032W	MCM3	het	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.273	1.53E-58	YJL025W	RRN7	het	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.267	7.85E-56	YGL041C_d	YGL041C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.238	1.44E-44	YPL157W	TGS1	hom	Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.230	1.82E-41	YDL102W	POL3	het	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.230	2.73E-41	YGL200C	EMP24	hom	Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.222	1.34E-38	YNL101W	AVT4	hom	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters