YMR272W-B_p

Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR272W-B / YMR272W-B

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.61|P-value:1.98E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.23|P-value:1.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.60|P-value:9.29E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.82|P-value:6.31E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.48|P-value:3.66E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.27|P-value:9.55E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.32|P-value:7.92E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.52|P-value:3.11E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.20|P-value:1.33E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.78|P-value:8.63E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.78|P-value:7.49E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.42|P-value:5.09E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.82|P-value:6.90E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.28|P-value:9.14E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.42|P-value:4.94E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.06|P-value:2.46E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.03|P-value:4.30E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.21|P-value:8.90E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.00|P-value:3.08E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-2.95|P-value:6.05E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.96|P-value:5.77E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.39|P-value:9.62E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.12|P-value:2.99E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.86|P-value:8.51E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.44|P-value:7.56E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.83|P-value:2.11E-11 ID:SGTC_2611|Compound:pyromycin|FD-Score:-5.33|P-value:1.76E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.11|P-value:3.16E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.11|P-value:3.17E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.23|P-value:1.15E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.60|P-value:2.06E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.61|P-value:1.98E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.23|P-value:1.17E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.60|P-value:9.29E-8 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.82|P-value:6.31E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.48|P-value:3.66E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.27|P-value:9.55E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:3.32|P-value:7.92E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.52|P-value:3.11E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.20|P-value:1.33E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.78|P-value:8.63E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.78|P-value:7.49E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-4.42|P-value:5.09E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.82|P-value:6.90E-6 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.28|P-value:9.14E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.42|P-value:4.94E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.06|P-value:2.46E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.03|P-value:4.30E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.21|P-value:8.90E-7 ID:SGTC_1734|Compound:st037168|FD-Score:3.00|P-value:3.08E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-2.95|P-value:6.05E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-2.96|P-value:5.77E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.39|P-value:9.62E-5 ID:SGTC_2404|Compound:5161160|FD-Score:-3.12|P-value:2.99E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.86|P-value:8.51E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.18|P-value:2.35E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.44|P-value:7.56E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:5.83|P-value:2.11E-11 ID:SGTC_2611|Compound:pyromycin|FD-Score:-5.33|P-value:1.76E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.11|P-value:3.16E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.11|P-value:3.17E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.23|P-value:1.15E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.60|P-value:2.06E-5

Top fitness defect scores for YMR272W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2610 ononetin 5.83 44.2 µM 2.11E-11 7 2.73E-9
2 SGTC_236 1509-0011 4.60 5.3 µM 9.29E-8 354 2.13E-6
3 SGTC_1589 2',5'-dimethoxyflavone 4.21 47.2 µM 8.90E-7 10 1.29E-5
4 SGTC_1251 0490-5699 3.82 265.0 µM 6.90E-6 37 6.55E-5
5 SGTC_1116 jasmonic acid 3.78 1.6 µM 8.63E-6 26 7.83E-5
6 SGTC_38 0929-0051 3.61 58.3 µM 1.98E-5 27 1.52E-4
7 SGTC_3265 9137266 3.60 49.5 µM 2.06E-5 15 1.56E-4
8 SGTC_1099 5-nonyloxytryptamine 3.52 2.9 µM 3.11E-5 33 2.17E-4
9 SGTC_245 methotrexate 3.48 289.6 µM 3.66E-5 55 2.47E-4
10 SGTC_1487 3970-0795 3.42 2.8 µM 4.94E-5 DNA intercalators 24 3.13E-4
11 SGTC_935 2996-0153 3.32 430.0 µM 7.92E-5 PDR1 39 4.56E-4
12 SGTC_1291 0993-0025 3.28 5.8 µM 9.14E-5 24 5.11E-4
13 SGTC_365 0121-0052 3.27 13.6 µM 9.55E-5 mitochondrial response to ROS 102 5.30E-4
14 SGTC_3205 9113483 3.23 49.5 µM 1.15E-4 65 6.14E-4
15 SGTC_164 4100-3994 3.23 89.6 µM 1.17E-4 70 6.24E-4
16 SGTC_1108 betulinic acid 3.20 729.1 nM 1.33E-4 35 6.88E-4
17 SGTC_1501 4491-0275 3.06 38.4 µM 2.46E-4 36 0.00112
18 SGTC_1734 st037168 3.00 69.4 µM 3.08E-4 72 0.00134
19 SGTC_1033 k072-0102 2.98 21.3 µM 3.32E-4 60S ribosome export 69 0.00143
20 SGTC_243 5hr heat shock (37°C) + splitomicin 2.82 1.0 µM 6.31E-4 heat shock/prefoldin 133 0.00238

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 7.04E-35 YPR191W QCR2 hom Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
0.207 7.98E-34 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.190 9.44E-29 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.188 3.67E-28 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.182 1.95E-26 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.181 3.20E-26 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.180 9.88E-26 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.176 1.08E-24 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.175 1.45E-24 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.175 1.60E-24 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.173 6.79E-24 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.170 2.73E-23 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.170 3.95E-23 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.162 4.45E-21 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.160 9.50E-21 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER