HIPHOP chemogenomics database

YMR274C / RCE1

Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR274C / RCE1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR274C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2225	6654152	7.55	15.4 µM	4.36E-13		3	2.23E-14
2	SGTC_1306	1185-0270	7.06	9.0 µM	1.10E-11	Golgi	23	8.16E-13
3	SGTC_161	4065-0411	6.37	162.2 µM	7.92E-10		24	9.57E-11
4	SGTC_3166	9102297	5.73	49.5 µM	2.85E-8	Golgi	16	5.16E-9
5	SGTC_3292	9120825	5.59	59.8 µM	5.64E-8		5	1.11E-8
6	SGTC_3197	9113331	5.46	49.5 µM	1.15E-7		10	2.43E-8
7	SGTC_2610	ononetin	5.09	44.2 µM	6.78E-7		17	1.76E-7
8	SGTC_2955	9076254	4.89	12.2 µM	1.73E-6		7	4.97E-7
9	SGTC_378	3970-0959	4.85	8.3 µM	2.06E-6		8	6.05E-7
10	SGTC_164	4100-3994	4.80	89.6 µM	2.60E-6		13	7.82E-7
11	SGTC_841	0251-0215	4.78	91.2 µM	2.84E-6		57	8.64E-7
12	SGTC_655	k060-0012	4.71	42.0 µM	3.97E-6		4	1.25E-6
13	SGTC_91	0417-1751	4.70	58.4 µM	4.02E-6	Golgi	32	1.27E-6
14	SGTC_2540	epiandrosterone	4.52	100.0 µM	9.09E-6		40	3.14E-6
15	SGTC_3179	9107801	4.50	49.5 µM	9.88E-6		2	3.45E-6
16	SGTC_2604	4'-hydroxychalcone	4.37	11.3 µM	1.66E-5		24	6.12E-6
17	SGTC_829	1635-0120	4.37	117.0 µM	1.69E-5	DNA damage response	32	6.25E-6
18	SGTC_210	3551-0445	4.28	56.8 µM	2.40E-5		55	9.24E-6
19	SGTC_1176	0848-0131	4.23	83.3 µM	2.95E-5	Golgi	18	1.16E-5
20	SGTC_1681	tripelennamine	4.22	100.0 µM	3.06E-5		15	1.21E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.149	4.01E-18	YGR029W	ERV1	het	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.120	3.61E-12	YOL146W	PSF3	het	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.118	6.15E-12	YPL051W	ARL3	hom	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.114	3.58E-11	YBR164C	ARL1	hom	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.108	4.42E-10	YJL004C	SYS1	hom	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.106	7.05E-10	YLR309C	IMH1	hom	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.098	1.32E-8	YLR262C	YPT6	hom	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.094	4.50E-8	YDR016C	DAD1	het	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.092	8.99E-8	YDR108W	TRS85	hom	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.091	1.44E-7	YML016C	PPZ1	hom	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.089	2.87E-7	YKL195W	MIA40	het	Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.088	3.20E-7	YEL053C	MAK10	hom	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.087	4.55E-7	YNL051W	COG5	hom	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.087	4.71E-7	YOR207C	RET1	het	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.087	4.86E-7	YKR042W	UTH1	hom	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication