YMR274C / RCE1

Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR274C / RCE1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.70|P-value:4.02E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:6.37|P-value:7.92E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:4.80|P-value:2.60E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:4.28|P-value:2.40E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.85|P-value:2.06E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.21|P-value:3.81E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.32|P-value:7.89E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.14|P-value:4.32E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.65|P-value:2.59E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.96|P-value:8.37E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.77|P-value:1.71E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.71|P-value:3.97E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:4.04|P-value:6.35E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.37|P-value:1.69E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:3.29|P-value:8.79E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.78|P-value:2.84E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:3.65|P-value:2.63E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.96|P-value:8.33E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.06|P-value:6.69E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:4.22|P-value:3.08E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.92|P-value:1.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.86|P-value:1.41E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.23|P-value:2.95E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.95|P-value:8.90E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.73|P-value:2.29E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.48|P-value:5.30E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.06|P-value:1.10E-11 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.28|P-value:9.06E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.36|P-value:7.06E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.52|P-value:4.18E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.73|P-value:2.01E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.62|P-value:3.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:2.79E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.22|P-value:3.06E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.38|P-value:6.49E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.17|P-value:3.71E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-5.08|P-value:8.67E-7 ID:SGTC_2191|Compound:5911152|FD-Score:-3.82|P-value:1.65E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.55|P-value:4.36E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.10|P-value:4.89E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.15|P-value:4.00E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-3.47|P-value:5.66E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.32|P-value:9.13E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.35|P-value:7.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.36|P-value:8.09E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.52|P-value:9.09E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.37|P-value:1.66E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.42|P-value:5.80E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:5.09|P-value:6.78E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.78|P-value:3.36E-6 ID:SGTC_2955|Compound:9076254|FD-Score:4.89|P-value:1.73E-6 ID:SGTC_3049|Compound:9092223|FD-Score:3.98|P-value:7.79E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.38|P-value:7.45E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.35|P-value:7.38E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.29|P-value:2.71E-5 ID:SGTC_3166|Compound:9102297|FD-Score:5.73|P-value:2.85E-8 ID:SGTC_3178|Compound:9107506|FD-Score:4.13|P-value:4.33E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.50|P-value:9.88E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.46|P-value:1.15E-7 ID:SGTC_3290|Compound:9121031|FD-Score:4.14|P-value:4.19E-5 ID:SGTC_3292|Compound:9120825|FD-Score:5.59|P-value:5.64E-8 ID:SGTC_3334|Compound:9142812|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.40|P-value:6.26E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.70|P-value:4.02E-6 ID:SGTC_161|Compound:4065-0411|FD-Score:6.37|P-value:7.92E-10 ID:SGTC_164|Compound:4100-3994|FD-Score:4.80|P-value:2.60E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:4.28|P-value:2.40E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:4.85|P-value:2.06E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.21|P-value:3.81E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.32|P-value:7.89E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.55|P-value:3.72E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:4.14|P-value:4.32E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.65|P-value:2.59E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.96|P-value:8.37E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.77|P-value:1.71E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:4.71|P-value:3.97E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:4.04|P-value:6.35E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.37|P-value:1.69E-5 ID:SGTC_834|Compound:0312-0008|FD-Score:3.29|P-value:8.79E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:4.78|P-value:2.84E-6 ID:SGTC_844|Compound:0330-0132|FD-Score:3.65|P-value:2.63E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.96|P-value:8.33E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.06|P-value:6.69E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:4.22|P-value:3.08E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.92|P-value:1.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.86|P-value:1.41E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.23|P-value:2.95E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.95|P-value:8.90E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:-3.73|P-value:2.29E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-3.48|P-value:5.30E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:7.06|P-value:1.10E-11 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.28|P-value:9.06E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.36|P-value:7.06E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.52|P-value:4.18E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.73|P-value:2.01E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.62|P-value:3.36E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:2.79E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.22|P-value:3.06E-5 ID:SGTC_1856|Compound:st057054|FD-Score:3.38|P-value:6.49E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.17|P-value:3.71E-5 ID:SGTC_2134|Compound:5324836|FD-Score:-5.08|P-value:8.67E-7 ID:SGTC_2191|Compound:5911152|FD-Score:-3.82|P-value:1.65E-4 ID:SGTC_2225|Compound:6654152|FD-Score:7.55|P-value:4.36E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.10|P-value:4.89E-5 ID:SGTC_2344|Compound:7990960|FD-Score:4.15|P-value:4.00E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-3.47|P-value:5.66E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.32|P-value:9.13E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.35|P-value:7.34E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.36|P-value:8.09E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.52|P-value:9.09E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.37|P-value:1.66E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.42|P-value:5.80E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:5.09|P-value:6.78E-7 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.81|P-value:1.47E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-4.78|P-value:3.36E-6 ID:SGTC_2955|Compound:9076254|FD-Score:4.89|P-value:1.73E-6 ID:SGTC_3049|Compound:9092223|FD-Score:3.98|P-value:7.79E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.38|P-value:7.45E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.35|P-value:7.38E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.29|P-value:2.71E-5 ID:SGTC_3166|Compound:9102297|FD-Score:5.73|P-value:2.85E-8 ID:SGTC_3178|Compound:9107506|FD-Score:4.13|P-value:4.33E-5 ID:SGTC_3179|Compound:9107801|FD-Score:4.50|P-value:9.88E-6 ID:SGTC_3197|Compound:9113331|FD-Score:5.46|P-value:1.15E-7 ID:SGTC_3290|Compound:9121031|FD-Score:4.14|P-value:4.19E-5 ID:SGTC_3292|Compound:9120825|FD-Score:5.59|P-value:5.64E-8 ID:SGTC_3334|Compound:9142812|FD-Score:-3.91|P-value:1.18E-4

Top fitness defect scores for YMR274C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2225 6654152 7.55 15.4 µM 4.36E-13 3 2.23E-14
2 SGTC_1306 1185-0270 7.06 9.0 µM 1.10E-11 Golgi 23 8.16E-13
3 SGTC_161 4065-0411 6.37 162.2 µM 7.92E-10 24 9.57E-11
4 SGTC_3166 9102297 5.73 49.5 µM 2.85E-8 Golgi 16 5.16E-9
5 SGTC_3292 9120825 5.59 59.8 µM 5.64E-8 5 1.11E-8
6 SGTC_3197 9113331 5.46 49.5 µM 1.15E-7 10 2.43E-8
7 SGTC_2610 ononetin 5.09 44.2 µM 6.78E-7 17 1.76E-7
8 SGTC_2955 9076254 4.89 12.2 µM 1.73E-6 7 4.97E-7
9 SGTC_378 3970-0959 4.85 8.3 µM 2.06E-6 8 6.05E-7
10 SGTC_164 4100-3994 4.80 89.6 µM 2.60E-6 13 7.82E-7
11 SGTC_841 0251-0215 4.78 91.2 µM 2.84E-6 57 8.64E-7
12 SGTC_655 k060-0012 4.71 42.0 µM 3.97E-6 4 1.25E-6
13 SGTC_91 0417-1751 4.70 58.4 µM 4.02E-6 Golgi 32 1.27E-6
14 SGTC_2540 epiandrosterone 4.52 100.0 µM 9.09E-6 40 3.14E-6
15 SGTC_3179 9107801 4.50 49.5 µM 9.88E-6 2 3.45E-6
16 SGTC_2604 4'-hydroxychalcone 4.37 11.3 µM 1.66E-5 24 6.12E-6
17 SGTC_829 1635-0120 4.37 117.0 µM 1.69E-5 DNA damage response 32 6.25E-6
18 SGTC_210 3551-0445 4.28 56.8 µM 2.40E-5 55 9.24E-6
19 SGTC_1176 0848-0131 4.23 83.3 µM 2.95E-5 Golgi 18 1.16E-5
20 SGTC_1681 tripelennamine 4.22 100.0 µM 3.06E-5 15 1.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.01E-18 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.120 3.61E-12 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.118 6.15E-12 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.114 3.58E-11 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.108 4.42E-10 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.106 7.05E-10 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.098 1.32E-8 YLR262C YPT6 hom Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
0.094 4.50E-8 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.092 8.99E-8 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.091 1.44E-7 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.089 2.87E-7 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.088 3.20E-7 YEL053C MAK10 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
0.087 4.55E-7 YNL051W COG5 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.087 4.71E-7 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.087 4.86E-7 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication