HIPHOP chemogenomics database

YMR278W / PGM3

Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR278W / PGM3

Click on Significant Values for Screen Details

Top fitness defect scores for YMR278W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2330	7979373	8.00	200.0 µM	4.58E-18	60S ribosome export	5	6.02E-16
2	SGTC_2336	9001819	5.76	198.7 µM	3.02E-10	heme biosynthesis & mitochondrial translocase	11	4.11E-9
3	SGTC_2785	7756463	4.77	72.7 µM	1.47E-7		11	9.18E-7
4	SGTC_2365	9042475	4.53	200.0 µM	5.48E-7		21	2.90E-6
5	SGTC_1019	4262-0212	4.26	3.4 µM	2.29E-6	ergosterol depletion effects on membrane	54	1.01E-5
6	SGTC_2626	ethyl orsellinate	4.22	100.0 µM	2.77E-6		28	1.20E-5
7	SGTC_1934	st074720	4.18	32.6 µM	3.52E-6		46	1.48E-5
8	SGTC_1077	5-fluorocytosine	4.14	377.0 nM	4.14E-6	exosome	13	1.70E-5
9	SGTC_3177	9107506	4.14	49.5 µM	4.21E-6	ERG2	7	1.73E-5
10	SGTC_1248	0469-0687	4.03	58.6 µM	7.12E-6		26	2.74E-5
11	SGTC_1535	tetrahydropapaveroline hydrobromide	3.96	54.3 µM	1.00E-5	RPP1 & pyrimidine depletion	11	3.69E-5
12	SGTC_1045	1348-1485	3.86	165.0 µM	1.64E-5		34	5.69E-5
13	SGTC_1935	st074532	3.69	41.6 µM	3.60E-5		41	1.13E-4
14	SGTC_1087	pterostilbene	3.65	9.1 µM	4.36E-5		34	1.34E-4
15	SGTC_2933	9026794	3.64	32.5 µM	4.43E-5		34	1.36E-4
16	SGTC_2753	fluvastatin	3.59	17.1 µM	5.52E-5	azole & statin	52	1.64E-4
17	SGTC_2204	7233102	3.58	200.0 µM	5.84E-5	60S ribosome export	6	1.73E-4
18	SGTC_3170	9103054	3.57	49.5 µM	5.95E-5	60S ribosome export	24	1.76E-4
19	SGTC_3190	9110366	3.55	49.5 µM	6.71E-5		17	1.95E-4
20	SGTC_2781	5567276	3.54	71.4 µM	7.05E-5		71	2.04E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.114	3.31E-11	YDR454C	GUK1	het	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.111	1.01E-10	YPR079W	MRL1	hom	Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.102	3.57E-9	YKL132C	RMA1	hom	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.098	1.12E-8	YDL221W_d	YDL221W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.096	2.75E-8	YOL109W	ZEO1	hom	Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.090	1.69E-7	YGL051W	MST27	hom	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.089	2.66E-7	YDL120W	YFH1	het	Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.084	9.82E-7	YER021W	RPN3	het	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.084	9.95E-7	YOR230W	WTM1	hom	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.084	9.94E-7	YOL107W_p	YOL107W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.082	1.73E-6	YLR082C	SRL2	hom	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.082	1.82E-6	YKR018C	YKR018C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.081	2.53E-6	YPL101W	ELP4	hom	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.079	5.28E-6	YML029W	USA1	hom	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.078	6.21E-6	YBL009W	ALK2	hom	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins