HIPHOP chemogenomics database
YMR302C / YME2 
Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR302C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.220 | 4.36E-38 | YPL212C | PUS1 | hom | tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA |
| 0.114 | 3.92E-11 | YHR185C | PFS1 | hom | Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation |
| 0.113 | 4.70E-11 | YBR052C | RFS1 | hom | Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication |
| 0.100 | 7.34E-9 | YJL027C_p | YJL027C_p | hom | Putative protein of unknown function |
| 0.097 | 2.16E-8 | YGL026C | TRP5 | hom | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
| 0.094 | 5.84E-8 | YLR388W | RPS29A | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication |
| 0.092 | 1.04E-7 | YMR304W | UBP15 | hom | Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p |
| 0.092 | 1.11E-7 | YDL211C_p | YDL211C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
| 0.091 | 1.31E-7 | YNL032W | SIW14 | hom | Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm |
| 0.090 | 2.01E-7 | YPL151C | PRP46 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs |
| 0.089 | 2.63E-7 | YDR007W | TRP1 | hom | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
| 0.087 | 4.94E-7 | YDR189W | SLY1 | het | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex |
| 0.086 | 7.83E-7 | YGL220W | FRA2 | hom | Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel |
| 0.083 | 1.35E-6 | YLL019C | KNS1 | hom | Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation |
| 0.083 | 1.49E-6 | YMR183C | SSO2 | hom | Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p |