YMR302C / YME2

Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR302C / YME2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:4.26E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.07|P-value:5.13E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:7.14|P-value:7.69E-12 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.13|P-value:4.06E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:16.00|P-value:5.18E-51 ID:SGTC_155|Compound:k072-0202|FD-Score:7.13|P-value:8.20E-12 ID:SGTC_259|Compound:usnic acid|FD-Score:7.26|P-value:3.57E-12 ID:SGTC_270|Compound:tamoxifen|FD-Score:-4.11|P-value:9.46E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.70|P-value:3.93E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.56|P-value:6.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.53|P-value:8.19E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.53|P-value:3.57E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.52|P-value:3.76E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.35|P-value:1.68E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.20|P-value:4.00E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.59|P-value:2.97E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.75|P-value:1.68E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.70|P-value:1.98E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.62|P-value:5.61E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.24|P-value:9.47E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.37|P-value:6.11E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.70|P-value:3.88E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.82|P-value:2.33E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.39|P-value:5.79E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-4.99|P-value:2.59E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.41|P-value:5.33E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.62|P-value:2.66E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.90|P-value:1.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-5.99|P-value:2.01E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.70|P-value:3.92E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:6.56|P-value:2.71E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.43|P-value:9.48E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:2.88E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.27|P-value:8.47E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.48|P-value:4.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.66|P-value:2.32E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.35|P-value:6.54E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.66|P-value:1.06E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.32|P-value:7.28E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.68|P-value:4.26E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.07|P-value:5.13E-5 ID:SGTC_96|Compound:0929-0093|FD-Score:7.14|P-value:7.69E-12 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.13|P-value:4.06E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:16.00|P-value:5.18E-51 ID:SGTC_155|Compound:k072-0202|FD-Score:7.13|P-value:8.20E-12 ID:SGTC_259|Compound:usnic acid|FD-Score:7.26|P-value:3.57E-12 ID:SGTC_270|Compound:tamoxifen|FD-Score:-4.11|P-value:9.46E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.70|P-value:3.93E-6 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.56|P-value:6.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.53|P-value:8.19E-6 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.53|P-value:3.57E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.52|P-value:3.76E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.66|P-value:2.34E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.52|P-value:3.74E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.35|P-value:1.68E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.87|P-value:1.08E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:5.20|P-value:4.00E-7 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.59|P-value:2.97E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.75|P-value:1.68E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.70|P-value:1.98E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.62|P-value:5.61E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.24|P-value:9.47E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.25|P-value:9.06E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.37|P-value:6.11E-4 ID:SGTC_1840|Compound:st055363|FD-Score:4.70|P-value:3.88E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.82|P-value:2.33E-6 ID:SGTC_2127|Compound:5253358|FD-Score:3.39|P-value:5.79E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-4.99|P-value:2.59E-6 ID:SGTC_2174|Compound:5790901|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_2203|Compound:7227154|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.41|P-value:5.33E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.62|P-value:2.66E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.90|P-value:1.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.64|P-value:2.51E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-5.99|P-value:2.01E-8 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.70|P-value:3.92E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:6.56|P-value:2.71E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.43|P-value:9.48E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.60|P-value:2.88E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.27|P-value:8.47E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.48|P-value:4.26E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.66|P-value:2.32E-4 ID:SGTC_3199|Compound:9111318|FD-Score:3.35|P-value:6.54E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.66|P-value:1.06E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.32|P-value:7.28E-4

Top fitness defect scores for YMR302C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_129 0088-0017 16.00 176.6 µM 5.18E-51 5 9.39E-58
2 SGTC_259 usnic acid 7.26 108.9 µM 3.57E-12 2 1.96E-13
3 SGTC_96 0929-0093 7.14 37.3 µM 7.69E-12 calcium & mitochondrial duress 3 4.68E-13
4 SGTC_155 k072-0202 7.13 43.6 µM 8.20E-12 1 5.03E-13
5 SGTC_2774 tamoxifen 6.56 10.9 µM 2.71E-10 1 2.65E-11
6 SGTC_1099 5-nonyloxytryptamine 5.20 2.9 µM 4.00E-7 4 1.01E-7
7 SGTC_1847 st056231 4.82 15.0 µM 2.33E-6 17 7.31E-7
8 SGTC_1840 st055363 4.70 71.0 µM 3.88E-6 2 1.30E-6
9 SGTC_273 hydroxyurea 4.70 18.1 mM 3.93E-6 heme biosynthesis & mitochondrial translocase 17 1.32E-6
10 SGTC_1571 st070080 4.62 73.4 µM 5.61E-6 4 1.96E-6
11 SGTC_310 1273-0058 4.53 1.1 µM 8.19E-6 mitochondrial stress 207 3.00E-6
12 SGTC_726 3448-4391 4.35 34.2 µM 1.68E-5 7 6.71E-6
13 SGTC_120 rhodamine 6G 4.13 52.3 µM 4.06E-5 mitochondrial processes 27 1.81E-5
14 SGTC_81 0411-0046 4.07 10.0 µM 5.13E-5 22 2.35E-5
15 SGTC_1096 rimcazole 3.87 32.2 µM 1.08E-4 14 5.40E-5
16 SGTC_1116 jasmonic acid 3.75 1.6 µM 1.68E-4 27 8.84E-5
17 SGTC_79 0052-0007 3.73 94.1 µM 1.78E-4 45 9.45E-5
18 SGTC_2777 climbazole 3.73 1.5 µM 1.82E-4 iron homeostasis 60 9.65E-5
19 SGTC_1537 2',6'-dihydroxyflavanone 3.70 78.0 µM 1.98E-4 22 1.06E-4
20 SGTC_3185 9108267 3.66 49.5 µM 2.32E-4 60S ribosome export 22 1.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.220 4.36E-38 YPL212C PUS1 hom tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
0.114 3.92E-11 YHR185C PFS1 hom Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
0.113 4.70E-11 YBR052C RFS1 hom Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.100 7.34E-9 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.097 2.16E-8 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.094 5.84E-8 YLR388W RPS29A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication
0.092 1.04E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.092 1.11E-7 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.091 1.31E-7 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.090 2.01E-7 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.089 2.63E-7 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.087 4.94E-7 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.086 7.83E-7 YGL220W FRA2 hom Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.083 1.35E-6 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.083 1.49E-6 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p