YMR305C / SCW10

Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR305C / SCW10

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.56|P-value:1.73E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.30|P-value:6.27E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:5.95E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.57|P-value:1.47E-4 ID:SGTC_393|Compound:acivicin|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.05|P-value:1.91E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.70|P-value:8.50E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.56|P-value:1.75E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.01|P-value:2.33E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.26|P-value:4.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.16|P-value:1.17E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:2.61E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:5.59|P-value:6.56E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.83|P-value:4.19E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.29|P-value:3.64E-8 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.11|P-value:1.51E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.15|P-value:7.04E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.96|P-value:2.87E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.55|P-value:1.55E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.26|P-value:4.42E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.34|P-value:3.46E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.57|P-value:1.45E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.19|P-value:1.02E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-13.90|P-value:4.69E-46 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.53|P-value:1.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.94|P-value:2.52E-7 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.72|P-value:7.88E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.12|P-value:7.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-3.83|P-value:4.15E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.11|P-value:7.92E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.56|P-value:1.73E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.46|P-value:2.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:4.30|P-value:6.27E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:3.79|P-value:5.95E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:3.57|P-value:1.47E-4 ID:SGTC_393|Compound:acivicin|FD-Score:4.11|P-value:1.46E-5 ID:SGTC_534|Compound:k292-0788|FD-Score:4.05|P-value:1.91E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:3.70|P-value:8.50E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.56|P-value:1.75E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.43|P-value:2.09E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:4.01|P-value:2.33E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:3.26|P-value:4.73E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:4.16|P-value:1.17E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:2.61E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:5.59|P-value:6.56E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.83|P-value:4.19E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.29|P-value:3.64E-8 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.11|P-value:1.51E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.15|P-value:7.04E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.46|P-value:2.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.96|P-value:2.87E-5 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.24|P-value:4.29E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.63|P-value:1.14E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.55|P-value:1.55E-4 ID:SGTC_2160|Compound:5660466|FD-Score:5.26|P-value:4.42E-8 ID:SGTC_2297|Compound:7971671|FD-Score:4.02|P-value:2.17E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.34|P-value:3.46E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.57|P-value:1.45E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.19|P-value:1.02E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-13.90|P-value:4.69E-46 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.53|P-value:1.41E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.94|P-value:2.52E-7 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.72|P-value:7.88E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.12|P-value:7.69E-4 ID:SGTC_2785|Compound:7756463|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-3.83|P-value:4.15E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.11|P-value:7.92E-4

Top fitness defect scores for YMR305C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_896 0964-0007 5.59 44.5 µM 6.56E-9 5 1.17E-8
2 SGTC_1110 3-hydroxy-3'-methoxyflavone 5.29 1.2 µM 3.64E-8 iron homeostasis 21 6.07E-8
3 SGTC_2160 5660466 5.26 132.9 µM 4.42E-8 60S ribosome export 2 7.32E-8
4 SGTC_2566 crystal violet carbinol 4.94 226.0 nM 2.52E-7 19 3.91E-7
5 SGTC_36 0335-0881 4.56 14.2 µM 1.73E-6 ubiquinone biosynthesis & proteasome 94 2.50E-6
6 SGTC_785 1270-0111 4.56 65.3 µM 1.75E-6 14 2.53E-6
7 SGTC_2785 7756463 4.37 72.7 µM 4.50E-6 18 6.29E-6
8 SGTC_216 k038-0035 4.30 28.4 µM 6.27E-6 ubiquinone biosynthesis & proteasome 38 8.67E-6
9 SGTC_2529 gangaleoidin 4.19 93.6 µM 1.02E-5 13 1.38E-5
10 SGTC_851 0394-0702 4.16 453.0 µM 1.17E-5 mitochondrial processes 9 1.59E-5
11 SGTC_393 acivicin 4.11 6.2 µM 1.46E-5 18 1.95E-5
12 SGTC_1325 1431-0015 4.11 227.0 µM 1.51E-5 Golgi 15 2.02E-5
13 SGTC_534 k292-0788 4.05 63.4 µM 1.91E-5 mitochondrial processes 27 2.54E-5
14 SGTC_2297 7971671 4.02 152.3 µM 2.17E-5 RNA processing & uracil transport 20 2.87E-5
15 SGTC_792 4534-1957 4.01 155.0 µM 2.33E-5 31 3.07E-5
16 SGTC_891 0929-0073 3.98 133.0 µM 2.61E-5 21 3.43E-5
17 SGTC_1889 st059080 3.96 5.2 µM 2.87E-5 14 3.76E-5
18 SGTC_268 camptothecin 3.79 39.6 µM 5.95E-5 DNA damage response 82 7.60E-5
19 SGTC_2674 ligustilide 3.72 100.0 µM 7.88E-5 9 9.97E-5
20 SGTC_541 4513-1321 3.70 94.0 µM 8.50E-5 25 1.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.41E-30 YML110C COQ5 hom 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.180 5.95E-26 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.180 6.04E-26 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.160 1.25E-20 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.160 1.36E-20 YOL153C YOL153C hom Hypothetical protein
0.154 2.70E-19 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.148 6.63E-18 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
0.147 1.20E-17 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.145 3.91E-17 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.143 8.04E-17 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.143 1.05E-16 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.141 2.17E-16 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.138 1.15E-15 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.138 1.16E-15 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.36E-15 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery