YMR306C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR306C-A / YMR306C-A

Click on Significant Values for Screen Details ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.90|P-value:9.95E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.17|P-value:3.44E-4 ID:SGTC_269|Compound:exalamide|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.91|P-value:7.30E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:5.07|P-value:2.91E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.92|P-value:9.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-2.91|P-value:9.71E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:7.62|P-value:1.77E-16 ID:SGTC_560|Compound:2332-1943|FD-Score:4.47|P-value:8.45E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.15|P-value:3.74E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.02|P-value:6.04E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.63|P-value:3.57E-7 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.92|P-value:8.84E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:2.95|P-value:7.74E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.37|P-value:1.45E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.93|P-value:8.95E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_1715|Compound:st032160|FD-Score:5.51|P-value:1.85E-9 ID:SGTC_1724|Compound:st037281|FD-Score:3.12|P-value:4.19E-4 ID:SGTC_1767|Compound:st044992|FD-Score:5.33|P-value:5.72E-9 ID:SGTC_1855|Compound:st056195|FD-Score:2.99|P-value:6.79E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.39|P-value:1.48E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.07|P-value:6.60E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-3.17|P-value:3.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.80|P-value:2.50E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.17|P-value:3.46E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.04|P-value:7.77E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.06|P-value:5.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.68|P-value:2.78E-7 ID:SGTC_2395|Compound:5646831|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:4.91E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.86|P-value:1.79E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.89|P-value:1.53E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.08|P-value:4.83E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.61|P-value:5.54E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.06|P-value:5.60E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:-2.90|P-value:9.95E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.17|P-value:3.44E-4 ID:SGTC_269|Compound:exalamide|FD-Score:2.92|P-value:8.74E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:4.91|P-value:7.30E-8 ID:SGTC_359|Compound:0081-0058|FD-Score:5.07|P-value:2.91E-8 ID:SGTC_379|Compound:3970-0972|FD-Score:3.15|P-value:3.73E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.92|P-value:9.24E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:-2.91|P-value:9.71E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:7.62|P-value:1.77E-16 ID:SGTC_560|Compound:2332-1943|FD-Score:4.47|P-value:8.45E-7 ID:SGTC_655|Compound:k060-0012|FD-Score:3.15|P-value:3.74E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.02|P-value:6.04E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.63|P-value:3.57E-7 ID:SGTC_1224|Compound:0823-0416|FD-Score:2.92|P-value:8.84E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:2.95|P-value:7.74E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.37|P-value:1.45E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.93|P-value:8.95E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_1715|Compound:st032160|FD-Score:5.51|P-value:1.85E-9 ID:SGTC_1724|Compound:st037281|FD-Score:3.12|P-value:4.19E-4 ID:SGTC_1767|Compound:st044992|FD-Score:5.33|P-value:5.72E-9 ID:SGTC_1855|Compound:st056195|FD-Score:2.99|P-value:6.79E-4 ID:SGTC_1932|Compound:st074806|FD-Score:-3.39|P-value:1.48E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.07|P-value:6.60E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-3.17|P-value:3.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.80|P-value:2.50E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.17|P-value:3.46E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.04|P-value:7.77E-6 ID:SGTC_2318|Compound:6029776|FD-Score:3.06|P-value:5.28E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.68|P-value:2.78E-7 ID:SGTC_2395|Compound:5646831|FD-Score:2.94|P-value:8.08E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.64|P-value:4.91E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.12|P-value:4.18E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.81|P-value:2.28E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.86|P-value:1.79E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.89|P-value:1.53E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.08|P-value:4.83E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.61|P-value:5.54E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.06|P-value:5.60E-4

Top fitness defect scores for YMR306C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_553 k007-0256 7.62 45.7 µM 1.77E-16 heme biosynthesis & mitochondrial translocase 5 1.24E-14
2 SGTC_1715 st032160 5.51 10.2 µM 1.85E-9 18 1.79E-8
3 SGTC_1767 st044992 5.33 70.3 µM 5.72E-9 5 4.81E-8
4 SGTC_359 0081-0058 5.07 15.9 µM 2.91E-8 60S ribosome export 18 2.00E-7
5 SGTC_355 1311-2252 4.91 105.0 µM 7.30E-8 5 4.50E-7
6 SGTC_2344 7990960 4.68 77.0 µM 2.78E-7 15 1.46E-6
7 SGTC_993 3909-8757 4.63 62.7 µM 3.57E-7 13 1.81E-6
8 SGTC_560 2332-1943 4.47 155.0 µM 8.45E-7 3 3.86E-6
9 SGTC_1448 4255-0083 4.37 152.0 µM 1.45E-6 ERG2 12 6.21E-6
10 SGTC_1937 st074714 4.07 47.2 µM 6.60E-6 37 2.36E-5
11 SGTC_2259 7964009 4.04 200.0 µM 7.77E-6 superoxide 28 2.72E-5
12 SGTC_2941 9056145 3.89 11.2 µM 1.53E-5 20 4.94E-5
13 SGTC_2927 9011802 3.86 47.9 µM 1.79E-5 27 5.66E-5
14 SGTC_2797 7859098 3.81 81.8 µM 2.28E-5 29 7.00E-5
15 SGTC_2563 tomatine 3.64 8.5 µM 4.91E-5 65 1.38E-4
16 SGTC_3025 9087895 3.61 49.5 µM 5.54E-5 PDR1 49 1.53E-4
17 SGTC_3125 9127534 3.40 49.5 µM 1.36E-4 23 3.37E-4
18 SGTC_3265 9137266 3.40 49.5 µM 1.36E-4 19 3.38E-4
19 SGTC_1713 st033146 3.32 12.8 µM 1.91E-4 49 4.56E-4
20 SGTC_258 haloperidol 3.17 50.8 µM 3.44E-4 fatty acid desaturase (OLE1) 62 7.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 3.04E-15 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.108 3.45E-10 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.105 9.15E-10 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.103 2.52E-9 YOR149C SMP3 het Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.102 2.98E-9 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.100 6.21E-9 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.100 6.59E-9 YOR259C RPT4 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization
0.095 3.76E-8 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.092 7.99E-8 YBR025C OLA1 hom P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress
0.092 8.55E-8 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.091 1.30E-7 YLR098C CHA4 hom DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
0.088 3.00E-7 YOL126C MDH2 hom Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
0.087 4.98E-7 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.084 1.16E-6 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.084 1.20E-6 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive