YMR308C / PSE1

Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR308C / PSE1

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:3.52|P-value:3.14E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:5.04|P-value:5.86E-9 ID:SGTC_299|Compound:1273-0059|FD-Score:5.37|P-value:6.54E-10 ID:SGTC_300|Compound:r073-0011|FD-Score:3.45|P-value:4.31E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:4.68|P-value:5.85E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.19|P-value:2.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.07|P-value:2.30E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.13|P-value:3.43E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.53|P-value:1.46E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:5.21|P-value:1.97E-9 ID:SGTC_379|Compound:3970-0972|FD-Score:2.97|P-value:3.40E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.04|P-value:4.75E-12 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:2.02E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.54|P-value:3.33E-7 ID:SGTC_774|Compound:k060-0086|FD-Score:3.09|P-value:2.07E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-2.87|P-value:9.18E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-2.92|P-value:7.62E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:9.24E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:2.33E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:2.76|P-value:7.83E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.32|P-value:1.13E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.71|P-value:2.61E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.96|P-value:7.79E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:2.84|P-value:5.67E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.81|P-value:6.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.09|P-value:2.09E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.74|P-value:8.41E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.01|P-value:5.46E-4 ID:SGTC_2020|Compound:4017018|FD-Score:2.79|P-value:7.02E-4 ID:SGTC_2059|Compound:5238311|FD-Score:2.75|P-value:8.33E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.73|P-value:1.12E-7 ID:SGTC_2332|Compound:7982454|FD-Score:2.84|P-value:5.80E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.96|P-value:3.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.31|P-value:1.59E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.25|P-value:1.07E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.77|P-value:3.27E-8 ID:SGTC_2475|Compound:5812728|FD-Score:3.57|P-value:2.48E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:7.98|P-value:1.42E-19 ID:SGTC_2570|Compound:licareol|FD-Score:-4.63|P-value:1.99E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-3.27|P-value:1.91E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.14|P-value:3.07E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.92|P-value:7.85E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.65|P-value:1.76E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.59|P-value:4.66E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.74|P-value:8.49E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.61|P-value:2.04E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.85|P-value:5.64E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.08|P-value:4.54E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-9.74|P-value:2.52E-27 ID:SGTC_3043|Compound:9092303|FD-Score:-3.08|P-value:4.05E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.01|P-value:2.95E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.52|P-value:3.14E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:5.04|P-value:5.86E-9 ID:SGTC_299|Compound:1273-0059|FD-Score:5.37|P-value:6.54E-10 ID:SGTC_300|Compound:r073-0011|FD-Score:3.45|P-value:4.31E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:4.68|P-value:5.85E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.19|P-value:2.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.07|P-value:2.30E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:-3.13|P-value:3.43E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.53|P-value:1.46E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:5.21|P-value:1.97E-9 ID:SGTC_379|Compound:3970-0972|FD-Score:2.97|P-value:3.40E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.04|P-value:4.75E-12 ID:SGTC_547|Compound:1120-0019|FD-Score:-3.76|P-value:2.02E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.54|P-value:3.33E-7 ID:SGTC_774|Compound:k060-0086|FD-Score:3.09|P-value:2.07E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-2.87|P-value:9.18E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-2.92|P-value:7.62E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:9.24E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:3.58|P-value:2.33E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:2.76|P-value:7.83E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.32|P-value:1.13E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.71|P-value:2.61E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.96|P-value:7.79E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:2.84|P-value:5.67E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.81|P-value:6.45E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.92|P-value:4.16E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.09|P-value:2.09E-4 ID:SGTC_1810|Compound:st050138|FD-Score:2.74|P-value:8.41E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.10|P-value:2.01E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-3.01|P-value:5.46E-4 ID:SGTC_2020|Compound:4017018|FD-Score:2.79|P-value:7.02E-4 ID:SGTC_2059|Compound:5238311|FD-Score:2.75|P-value:8.33E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.73|P-value:1.12E-7 ID:SGTC_2332|Compound:7982454|FD-Score:2.84|P-value:5.80E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.96|P-value:3.51E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.31|P-value:1.59E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.25|P-value:1.07E-4 ID:SGTC_2471|Compound:5466956|FD-Score:4.77|P-value:3.27E-8 ID:SGTC_2475|Compound:5812728|FD-Score:3.57|P-value:2.48E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:7.98|P-value:1.42E-19 ID:SGTC_2570|Compound:licareol|FD-Score:-4.63|P-value:1.99E-7 ID:SGTC_2591|Compound:skatole|FD-Score:-3.27|P-value:1.91E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-4.14|P-value:3.07E-6 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.92|P-value:7.85E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.65|P-value:1.76E-7 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.59|P-value:4.66E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.74|P-value:8.49E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.61|P-value:2.04E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.85|P-value:5.64E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.08|P-value:4.54E-9 ID:SGTC_2965|Compound:9082772|FD-Score:-9.74|P-value:2.52E-27 ID:SGTC_3043|Compound:9092303|FD-Score:-3.08|P-value:4.05E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.01|P-value:2.95E-4

Top fitness defect scores for YMR308C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2568 diosmetin 7.98 100.0 µM 1.42E-19 1 7.35E-16 2.63
2 SGTC_393 acivicin 6.04 6.2 µM 4.75E-12 4 7.73E-10 0.91
3 SGTC_299 1273-0059 5.37 1.4 µM 6.54E-10 4 3.97E-8 0.59
4 SGTC_335 4077-0256 5.21 27.6 µM 1.97E-9 2 9.60E-8 0.06
5 SGTC_2959 9079155 5.08 11.0 µM 4.54E-9 4 1.87E-7 0.02
6 SGTC_293 4049-0273 5.04 38.5 µM 5.86E-9 1 2.29E-7 0.81
7 SGTC_2471 5466956 4.77 24.8 µM 3.27E-8 mitochondrial processes 11 9.06E-7 0.48
8 SGTC_302 1094-0063 4.68 18.9 µM 5.85E-8 11 1.44E-6 0.06
9 SGTC_315 k915-0449 4.53 187.0 µM 1.46E-7 6 3.00E-6 0.43
10 SGTC_2716 st080858 3.61 38.6 µM 2.04E-5 60S ribosome export 3 1.55E-4 0.12
11 SGTC_933 2914-0560 3.58 114.0 µM 2.33E-5 9 1.73E-4 0.02
12 SGTC_2475 5812728 3.57 15.0 µM 2.48E-5 mitochondrial processes 19 1.82E-4 0.09
13 SGTC_212 3807-4682 3.52 38.8 µM 3.14E-5 tubulin folding & SWR complex 31 2.19E-4 0.12
14 SGTC_300 r073-0011 3.45 5.0 µM 4.31E-5 4 2.83E-4 0.15
15 SGTC_2411 st077133 3.25 39.9 µM 1.07E-4 RNA pol III & RNase P/MRP 29 5.84E-4 0.02
16 SGTC_1996 st072960 3.10 66.8 µM 2.01E-4 7 9.71E-4 0.01
17 SGTC_774 k060-0086 3.09 136.0 µM 2.07E-4 14 9.91E-4 0.02
18 SGTC_1746 st038117 3.09 42.0 µM 2.09E-4 12 0.00100 0.07
19 SGTC_310 1273-0058 3.07 1.1 µM 2.30E-4 mitochondrial stress 3 0.00108 0.10
20 SGTC_3067 9117431 3.01 49.5 µM 2.95E-4 25 0.00132 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 3.47E-40 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.186 1.70E-27 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.173 5.96E-24 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.160 9.32E-21 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.158 2.63E-20 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.158 3.92E-20 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.151 1.36E-18 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.148 5.81E-18 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.147 1.06E-17 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.143 7.47E-17 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.143 8.93E-17 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142 1.48E-16 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.142 1.64E-16 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.138 1.23E-15 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.137 1.37E-15 YLR438C-A LSM3 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress