YMR312W / ELP6

Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR312W / ELP6

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.98|P-value:8.64E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.72|P-value:4.38E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.39|P-value:6.94E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.42|P-value:6.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.54|P-value:4.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.64|P-value:7.85E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.53|P-value:1.30E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.58|P-value:4.47E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.56|P-value:3.97E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.03|P-value:7.35E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:6.55|P-value:3.73E-10 ID:SGTC_726|Compound:3448-4391|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:5.58|P-value:7.47E-8 ID:SGTC_729|Compound:4092-0585|FD-Score:3.80|P-value:1.68E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.55|P-value:9.07E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:6.68|P-value:1.70E-10 ID:SGTC_801|Compound:0866-0028|FD-Score:3.30|P-value:9.22E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.41|P-value:6.50E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.85|P-value:1.43E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.38|P-value:7.03E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-6.09|P-value:6.91E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.25|P-value:5.03E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.82|P-value:1.58E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.94|P-value:1.02E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.43|P-value:6.02E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.20|P-value:3.72E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.88|P-value:1.26E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.37|P-value:7.38E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.99|P-value:8.48E-5 ID:SGTC_1611|Compound:st001856|FD-Score:7.09|P-value:1.37E-11 ID:SGTC_1683|Compound:st010134|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.53|P-value:1.00E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:7.68E-26 ID:SGTC_1871|Compound:st057448|FD-Score:3.84|P-value:1.47E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.49|P-value:4.90E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.50|P-value:4.75E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.63|P-value:3.05E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.50|P-value:5.78E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-4.30|P-value:3.17E-5 ID:SGTC_2302|Compound:7771753|FD-Score:9.34|P-value:9.28E-19 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.73|P-value:2.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.89|P-value:6.43E-14 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.18|P-value:7.58E-12 ID:SGTC_2695|Compound:st077686|FD-Score:-3.82|P-value:1.90E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.38|P-value:8.47E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.13|P-value:5.04E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.90|P-value:1.17E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.11|P-value:5.36E-5 ID:SGTC_37|Compound:0566-0070|FD-Score:3.98|P-value:8.64E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.81|P-value:1.66E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:4.72|P-value:4.38E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.39|P-value:6.94E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.42|P-value:6.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.54|P-value:4.15E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.64|P-value:7.85E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.53|P-value:1.30E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.58|P-value:4.47E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.29|P-value:9.50E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.56|P-value:3.97E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:4.03|P-value:7.35E-5 ID:SGTC_713|Compound:1488-1073|FD-Score:6.55|P-value:3.73E-10 ID:SGTC_726|Compound:3448-4391|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:5.58|P-value:7.47E-8 ID:SGTC_729|Compound:4092-0585|FD-Score:3.80|P-value:1.68E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.55|P-value:9.07E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:6.68|P-value:1.70E-10 ID:SGTC_801|Compound:0866-0028|FD-Score:3.30|P-value:9.22E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.41|P-value:6.50E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.85|P-value:1.43E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.38|P-value:7.03E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-6.09|P-value:6.91E-9 ID:SGTC_1131|Compound:3454-3128|FD-Score:-5.25|P-value:5.03E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.82|P-value:1.58E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.94|P-value:1.02E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.43|P-value:6.02E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.20|P-value:3.72E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.88|P-value:1.26E-4 ID:SGTC_1405|Compound:3909-7894|FD-Score:3.37|P-value:7.38E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.99|P-value:8.48E-5 ID:SGTC_1611|Compound:st001856|FD-Score:7.09|P-value:1.37E-11 ID:SGTC_1683|Compound:st010134|FD-Score:3.85|P-value:1.42E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.53|P-value:1.00E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.10|P-value:7.68E-26 ID:SGTC_1871|Compound:st057448|FD-Score:3.84|P-value:1.47E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.49|P-value:4.90E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.50|P-value:4.75E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.63|P-value:3.05E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.50|P-value:5.78E-4 ID:SGTC_2300|Compound:7976697|FD-Score:-4.30|P-value:3.17E-5 ID:SGTC_2302|Compound:7771753|FD-Score:9.34|P-value:9.28E-19 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.73|P-value:2.21E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.89|P-value:6.43E-14 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.18|P-value:7.58E-12 ID:SGTC_2695|Compound:st077686|FD-Score:-3.82|P-value:1.90E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.38|P-value:8.47E-4 ID:SGTC_2882|Compound:9058044|FD-Score:4.13|P-value:5.04E-5 ID:SGTC_3009|Compound:9080819|FD-Score:3.70|P-value:2.43E-4 ID:SGTC_3043|Compound:9092303|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.90|P-value:1.17E-4 ID:SGTC_3093|Compound:9117344|FD-Score:4.11|P-value:5.36E-5

Top fitness defect scores for YMR312W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 11.10 4.0 nM 7.68E-26 30 4.42E-29
2 SGTC_2302 7771753 9.34 200.0 µM 9.28E-19 2 4.97E-21
3 SGTC_2679 rapamycin 7.89 1.0 nM 6.43E-14 43 1.56E-15
4 SGTC_2688 kanamycin b 7.18 96.7 µM 7.58E-12 calcium & mitochondrial duress 101 3.50E-13
5 SGTC_1611 st001856 7.09 99.4 µM 1.37E-11 1 6.86E-13
6 SGTC_800 3448-7362 6.68 155.0 µM 1.70E-10 translation 32 1.19E-11
7 SGTC_713 1488-1073 6.55 324.0 µM 3.73E-10 ERG2 3 2.90E-11
8 SGTC_728 3030-5151 5.58 22.5 µM 7.47E-8 2 1.17E-8
9 SGTC_1772 st048439 5.53 82.2 µM 1.00E-7 13 1.63E-8
10 SGTC_175 3793-3120 4.72 23.7 µM 4.38E-6 5 1.17E-6
11 SGTC_735 3076-0345 4.55 636.0 µM 9.07E-6 18 2.66E-6
12 SGTC_1216 1165-0504 4.20 9.7 µM 3.72E-5 12 1.31E-5
13 SGTC_2882 9058044 4.13 58.4 µM 5.04E-5 13 1.84E-5
14 SGTC_3093 9117344 4.11 49.5 µM 5.36E-5 60S ribosome export 15 1.97E-5
15 SGTC_611 3453-1652 4.03 23.7 µM 7.35E-5 15 2.81E-5
16 SGTC_1599 8-chlro-1-tetrahydronorharmanone 3.99 90.6 µM 8.48E-5 36 3.31E-5
17 SGTC_37 0566-0070 3.98 1.6 µM 8.64E-5 27 3.38E-5
18 SGTC_1155 4088-0394 3.94 48.2 µM 1.02E-4 28 4.06E-5
19 SGTC_726 3448-4391 3.92 34.2 µM 1.10E-4 12 4.44E-5
20 SGTC_3052 9092717 3.90 49.5 µM 1.17E-4 30 4.76E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 4.55E-62 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.281 1.18E-61 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.272 6.88E-58 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.263 2.52E-54 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.260 6.96E-53 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.259 3.53E-52 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.251 1.81E-49 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.246 1.69E-47 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.233 1.11E-42 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.221 1.69E-38 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.210 7.63E-35 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.210 8.02E-35 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.206 1.67E-33 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.201 8.32E-32 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.193 1.89E-29 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb