HIPHOP chemogenomics database

YMR316C-B_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR316C-B / YMR316C-B

Click on Significant Values for Screen Details

Top fitness defect scores for YMR316C-B deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_961	1252-1571	12.10	372.0 µM	1.09E-43		1	9.02E-34
2	SGTC_763	3453-1109	8.20	128.0 µM	2.35E-21		1	1.16E-16
3	SGTC_658	3253-0951	6.23	102.0 µM	3.97E-13	calcium & mitochondrial duress	13	2.34E-10
4	SGTC_740	k014-0057	5.78	261.0 µM	1.46E-11		3	3.71E-9
5	SGTC_1390	3413-2614	4.97	145.0 µM	5.30E-9	fatty acid desaturase (OLE1)	8	3.41E-7
6	SGTC_960	1222-0186	4.96	7.7 µM	5.53E-9		14	3.52E-7
7	SGTC_568	1193-0097	4.82	7.5 µM	1.43E-8	ERAD & cell cycle	95	7.29E-7
8	SGTC_2973	9094665	4.73	18.0 µM	2.46E-8	NEO1	18	1.11E-6
9	SGTC_127	0180-0333	4.52	59.1 µM	9.60E-8	mitochondrial response to ROS	23	3.14E-6
10	SGTC_2298	7976326	4.46	193.8 µM	1.36E-7		3	4.11E-6
11	SGTC_2851	9015922	4.33	71.4 µM	2.88E-7		25	7.32E-6
12	SGTC_672	1441-0018	4.10	53.7 µM	1.12E-6		16	2.07E-5
13	SGTC_934	2950-0684	3.96	338.0 µM	2.43E-6		23	3.76E-5
14	SGTC_3	0833-0587	3.94	95.6 µM	2.65E-6	redox potentiating	22	4.02E-5
15	SGTC_2985	9022375	3.92	71.4 µM	2.98E-6	RPP1 & pyrimidine depletion	31	4.41E-5
16	SGTC_1755	st041960	3.91	45.2 µM	3.25E-6		26	4.70E-5
17	SGTC_1556	plumbagin	3.87	1.5 µM	3.96E-6	superoxide	22	5.48E-5
18	SGTC_648	0375-0473	3.53	33.3 µM	2.21E-5		26	2.06E-4
19	SGTC_953	1188-0045	3.47	9.7 µM	2.95E-5	60S ribosome export	43	2.57E-4
20	SGTC_1765	st044815	3.44	90.4 µM	3.39E-5		40	2.86E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.154	3.24E-19	YGR216C	GPI1	het	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.147	9.91E-18	YML057W	CMP2	hom	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.117	1.14E-11	YOR351C	MEK1	hom	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.115	2.11E-11	YPL085W	SEC16	het	COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.109	2.45E-10	YGL208W	SIP2	hom	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
0.108	3.35E-10	YGR110W	CLD1	hom	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.105	9.29E-10	YDR026C	NSI1	hom	RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.096	2.52E-8	YCL075W	YCL075W	hom	Pseudogene: encodes fragment of Ty Pol protein
0.091	1.50E-7	YOR073W	SGO1	hom	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.089	2.09E-7	YBL042C	FUI1	hom	High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress
0.089	2.48E-7	YKL112W	ABF1	het	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.085	7.90E-7	YGL120C	PRP43	het	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
0.083	1.36E-6	YJL051W	IRC8	hom	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.083	1.72E-6	YPL214C	THI6	hom	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.082	1.84E-6	YKR039W	GAP1	hom	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth