YMR316C-B_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR316C-B / YMR316C-B

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.94|P-value:2.65E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.80|P-value:8.35E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.52|P-value:9.60E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:2.67|P-value:9.66E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.37|P-value:7.33E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.25|P-value:8.37E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.82|P-value:1.43E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.09|P-value:2.54E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.16|P-value:1.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.53|P-value:2.21E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:6.23|P-value:3.97E-13 ID:SGTC_671|Compound:0560-0003|FD-Score:2.76|P-value:6.75E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.10|P-value:1.12E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:5.78|P-value:1.46E-11 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.72|P-value:4.91E-8 ID:SGTC_763|Compound:3453-1109|FD-Score:8.20|P-value:2.35E-21 ID:SGTC_776|Compound:4476-4378|FD-Score:-2.87|P-value:6.36E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-2.87|P-value:6.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.34|P-value:8.53E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.96|P-value:2.43E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:2.82|P-value:5.28E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.47|P-value:2.95E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.96|P-value:5.53E-9 ID:SGTC_961|Compound:1252-1571|FD-Score:12.10|P-value:1.09E-43 ID:SGTC_1013|Compound:4112-3890|FD-Score:2.87|P-value:4.30E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.82|P-value:5.37E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.85|P-value:4.76E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.04|P-value:2.16E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.10|P-value:1.66E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.83|P-value:5.12E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.97|P-value:5.30E-9 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.27|P-value:7.64E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.81|P-value:5.67E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.10|P-value:1.63E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.87|P-value:3.96E-6 ID:SGTC_1615|Compound:st002656|FD-Score:3.06|P-value:1.96E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.91|P-value:3.25E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.44|P-value:3.39E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:2.96|P-value:2.98E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.62|P-value:8.79E-8 ID:SGTC_2037|Compound:5169046|FD-Score:-3.82|P-value:8.24E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.74|P-value:1.22E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_2298|Compound:7976326|FD-Score:4.46|P-value:1.36E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.35|P-value:5.27E-5 ID:SGTC_2387|Compound:9077560|FD-Score:2.70|P-value:8.77E-4 ID:SGTC_2477|Compound:5967686|FD-Score:2.75|P-value:7.13E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.83|P-value:7.53E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.33|P-value:2.88E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.62|P-value:2.29E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.73|P-value:2.46E-8 ID:SGTC_2985|Compound:9022375|FD-Score:3.92|P-value:2.98E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-3.60|P-value:2.46E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.94|P-value:2.65E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:-2.80|P-value:8.35E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:4.52|P-value:9.60E-8 ID:SGTC_211|Compound:3455-0679|FD-Score:2.67|P-value:9.66E-4 ID:SGTC_396|Compound:dithiazanine|FD-Score:-3.37|P-value:7.33E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:3.25|P-value:8.37E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:4.82|P-value:1.43E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.09|P-value:2.54E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.16|P-value:1.27E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.53|P-value:2.21E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:6.23|P-value:3.97E-13 ID:SGTC_671|Compound:0560-0003|FD-Score:2.76|P-value:6.75E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:4.10|P-value:1.12E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:5.78|P-value:1.46E-11 ID:SGTC_754|Compound:3474-0146|FD-Score:-4.72|P-value:4.91E-8 ID:SGTC_763|Compound:3453-1109|FD-Score:8.20|P-value:2.35E-21 ID:SGTC_776|Compound:4476-4378|FD-Score:-2.87|P-value:6.36E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-2.87|P-value:6.40E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.34|P-value:8.53E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.96|P-value:2.43E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:2.82|P-value:5.28E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.47|P-value:2.95E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:4.96|P-value:5.53E-9 ID:SGTC_961|Compound:1252-1571|FD-Score:12.10|P-value:1.09E-43 ID:SGTC_1013|Compound:4112-3890|FD-Score:2.87|P-value:4.30E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.82|P-value:5.37E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.85|P-value:4.76E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.04|P-value:2.16E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.10|P-value:1.66E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:2.83|P-value:5.12E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.97|P-value:5.30E-9 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.27|P-value:7.64E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.81|P-value:5.67E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.10|P-value:1.63E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:3.87|P-value:3.96E-6 ID:SGTC_1615|Compound:st002656|FD-Score:3.06|P-value:1.96E-4 ID:SGTC_1755|Compound:st041960|FD-Score:3.91|P-value:3.25E-6 ID:SGTC_1765|Compound:st044815|FD-Score:3.44|P-value:3.39E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:2.96|P-value:2.98E-4 ID:SGTC_1937|Compound:st074714|FD-Score:-4.62|P-value:8.79E-8 ID:SGTC_2037|Compound:5169046|FD-Score:-3.82|P-value:8.24E-6 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.74|P-value:1.22E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_2298|Compound:7976326|FD-Score:4.46|P-value:1.36E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.35|P-value:5.27E-5 ID:SGTC_2387|Compound:9077560|FD-Score:2.70|P-value:8.77E-4 ID:SGTC_2477|Compound:5967686|FD-Score:2.75|P-value:7.13E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.83|P-value:7.53E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.33|P-value:2.88E-7 ID:SGTC_2855|Compound:9016525|FD-Score:-3.62|P-value:2.29E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.73|P-value:2.46E-8 ID:SGTC_2985|Compound:9022375|FD-Score:3.92|P-value:2.98E-6 ID:SGTC_3324|Compound:9138759|FD-Score:-3.60|P-value:2.46E-5

Top fitness defect scores for YMR316C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_961 1252-1571 12.10 372.0 µM 1.09E-43 1 9.02E-34
2 SGTC_763 3453-1109 8.20 128.0 µM 2.35E-21 1 1.16E-16
3 SGTC_658 3253-0951 6.23 102.0 µM 3.97E-13 calcium & mitochondrial duress 13 2.34E-10
4 SGTC_740 k014-0057 5.78 261.0 µM 1.46E-11 3 3.71E-9
5 SGTC_1390 3413-2614 4.97 145.0 µM 5.30E-9 fatty acid desaturase (OLE1) 8 3.41E-7
6 SGTC_960 1222-0186 4.96 7.7 µM 5.53E-9 14 3.52E-7
7 SGTC_568 1193-0097 4.82 7.5 µM 1.43E-8 ERAD & cell cycle 95 7.29E-7
8 SGTC_2973 9094665 4.73 18.0 µM 2.46E-8 NEO1 18 1.11E-6
9 SGTC_127 0180-0333 4.52 59.1 µM 9.60E-8 mitochondrial response to ROS 23 3.14E-6
10 SGTC_2298 7976326 4.46 193.8 µM 1.36E-7 3 4.11E-6
11 SGTC_2851 9015922 4.33 71.4 µM 2.88E-7 25 7.32E-6
12 SGTC_672 1441-0018 4.10 53.7 µM 1.12E-6 16 2.07E-5
13 SGTC_934 2950-0684 3.96 338.0 µM 2.43E-6 23 3.76E-5
14 SGTC_3 0833-0587 3.94 95.6 µM 2.65E-6 redox potentiating 22 4.02E-5
15 SGTC_2985 9022375 3.92 71.4 µM 2.98E-6 RPP1 & pyrimidine depletion 31 4.41E-5
16 SGTC_1755 st041960 3.91 45.2 µM 3.25E-6 26 4.70E-5
17 SGTC_1556 plumbagin 3.87 1.5 µM 3.96E-6 superoxide 22 5.48E-5
18 SGTC_648 0375-0473 3.53 33.3 µM 2.21E-5 26 2.06E-4
19 SGTC_953 1188-0045 3.47 9.7 µM 2.95E-5 60S ribosome export 43 2.57E-4
20 SGTC_1765 st044815 3.44 90.4 µM 3.39E-5 40 2.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.24E-19 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.147 9.91E-18 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.117 1.14E-11 YOR351C MEK1 hom Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
0.115 2.11E-11 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.109 2.45E-10 YGL208W SIP2 hom One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
0.108 3.35E-10 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.105 9.29E-10 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.096 2.52E-8 YCL075W YCL075W hom Pseudogene: encodes fragment of Ty Pol protein
0.091 1.50E-7 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.089 2.09E-7 YBL042C FUI1 hom High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress
0.089 2.48E-7 YKL112W ABF1 het DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.085 7.90E-7 YGL120C PRP43 het RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
0.083 1.36E-6 YJL051W IRC8 hom Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
0.083 1.72E-6 YPL214C THI6 hom Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.082 1.84E-6 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth