YNL005C / MRP7

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL005C / MRP7

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.01|P-value:3.97E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.56|P-value:5.86E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.20|P-value:2.06E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.82|P-value:7.32E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.56|P-value:6.96E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:4.31|P-value:3.41E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.06|P-value:3.35E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.21|P-value:2.03E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.96|P-value:9.12E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.82|P-value:1.68E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:2.88E-33 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.61|P-value:9.64E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:13.90|P-value:2.25E-28 ID:SGTC_314|Compound:1671-0008|FD-Score:5.13|P-value:2.59E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.14|P-value:2.20E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.11|P-value:6.11E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.09|P-value:6.35E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.93|P-value:5.05E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.26|P-value:3.98E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.01|P-value:7.94E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.11|P-value:6.12E-4 ID:SGTC_1516|Compound:st013856|FD-Score:4.73|P-value:9.59E-5 ID:SGTC_1627|Compound:st003713|FD-Score:5.05|P-value:3.44E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-4.05|P-value:6.28E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.49|P-value:7.42E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.10|P-value:5.50E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.35|P-value:3.08E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.21|P-value:4.55E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.90|P-value:1.66E-6 ID:SGTC_2057|Compound:5236571|FD-Score:6.22|P-value:4.63E-7 ID:SGTC_2058|Compound:5236698|FD-Score:4.97|P-value:4.48E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.41|P-value:2.56E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.31|P-value:1.40E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.32|P-value:3.38E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.16|P-value:5.33E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.05|P-value:6.41E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.06|P-value:6.97E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.41|P-value:1.59E-11 ID:SGTC_2696|Compound:st077691|FD-Score:4.86|P-value:6.38E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.98|P-value:3.72E-5 ID:SGTC_2900|Compound:5328528|FD-Score:4.96|P-value:4.67E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-4.93|P-value:4.42E-5 ID:SGTC_2990|Compound:9074105|FD-Score:4.19|P-value:4.84E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.51|P-value:1.88E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.08|P-value:5.75E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.01|P-value:3.97E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.56|P-value:5.86E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:5.20|P-value:2.06E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.82|P-value:7.32E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:8.56|P-value:6.96E-12 ID:SGTC_116|Compound:0155-0182|FD-Score:4.31|P-value:3.41E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.06|P-value:3.35E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.21|P-value:2.03E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:3.96|P-value:9.12E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.82|P-value:1.68E-12 ID:SGTC_236|Compound:1509-0011|FD-Score:15.10|P-value:2.88E-33 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.61|P-value:9.64E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:13.90|P-value:2.25E-28 ID:SGTC_314|Compound:1671-0008|FD-Score:5.13|P-value:2.59E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.14|P-value:2.20E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.11|P-value:6.11E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.09|P-value:6.35E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.93|P-value:5.05E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.26|P-value:3.98E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:4.01|P-value:7.94E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.11|P-value:6.12E-4 ID:SGTC_1516|Compound:st013856|FD-Score:4.73|P-value:9.59E-5 ID:SGTC_1627|Compound:st003713|FD-Score:5.05|P-value:3.44E-5 ID:SGTC_1678|Compound:st019265|FD-Score:-4.05|P-value:6.28E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.49|P-value:7.42E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.10|P-value:5.50E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.35|P-value:3.08E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.21|P-value:4.55E-4 ID:SGTC_2051|Compound:5263410|FD-Score:5.90|P-value:1.66E-6 ID:SGTC_2057|Compound:5236571|FD-Score:6.22|P-value:4.63E-7 ID:SGTC_2058|Compound:5236698|FD-Score:4.97|P-value:4.48E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.41|P-value:2.56E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.31|P-value:1.40E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.32|P-value:3.38E-4 ID:SGTC_2344|Compound:7990960|FD-Score:4.16|P-value:5.33E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.05|P-value:6.41E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.06|P-value:6.97E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.41|P-value:1.59E-11 ID:SGTC_2696|Compound:st077691|FD-Score:4.86|P-value:6.38E-5 ID:SGTC_2784|Compound:7567673|FD-Score:-4.98|P-value:3.72E-5 ID:SGTC_2900|Compound:5328528|FD-Score:4.96|P-value:4.67E-5 ID:SGTC_2970|Compound:9090938|FD-Score:-4.93|P-value:4.42E-5 ID:SGTC_2990|Compound:9074105|FD-Score:4.19|P-value:4.84E-4 ID:SGTC_3006|Compound:9075424|FD-Score:4.51|P-value:1.88E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.08|P-value:5.75E-4

Top fitness defect scores for YNL005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.10 5.3 µM 2.88E-33 100 5.17E-52
2 SGTC_310 1273-0058 13.90 1.1 µM 2.25E-28 mitochondrial stress 11 3.24E-44
3 SGTC_173 1273-0061 8.82 2.7 µM 1.68E-12 mitochondrial stress 54 5.95E-19
4 SGTC_70 0141-0289 8.56 43.3 µM 6.96E-12 mitochondrial stress 32 5.67E-18
5 SGTC_2688 kanamycin b 8.41 96.7 µM 1.59E-11 calcium & mitochondrial duress 53 2.11E-17
6 SGTC_275 trichlorophene 7.61 5.7 µM 9.64E-10 mitochondrial stress 81 1.42E-14
7 SGTC_2057 5236571 6.22 38.3 µM 4.63E-7 RPP1 & pyrimidine depletion 6 2.48E-10
8 SGTC_2051 5263410 5.90 176.0 µM 1.66E-6 3 1.86E-9
9 SGTC_28 pentachloropyridine N-oxide 5.56 1.6 µM 5.86E-6 TSC3-RPN4 21 1.36E-8
10 SGTC_1921 5740136 5.49 50.0 µM 7.42E-6 TRP & mitochondrial translation 22 1.98E-8
11 SGTC_2232 chlorophetanol 5.31 41.5 µM 1.40E-5 TRP & mitochondrial translation 65 5.36E-8
12 SGTC_119 0121-0043 5.21 24.8 µM 2.03E-5 mitochondrial stress 50 9.64E-8
13 SGTC_63 0099-0242 5.20 26.7 µM 2.06E-5 mitochondrial stress 49 9.88E-8
14 SGTC_314 1671-0008 5.13 2.7 µM 2.59E-5 18 1.41E-7
15 SGTC_118 0083-0097 5.06 135.3 µM 3.35E-5 translation 51 2.12E-7
16 SGTC_1627 st003713 5.05 25.6 µM 3.44E-5 calcium & mitochondrial duress 41 2.21E-7
17 SGTC_10 0279-0212 5.01 42.6 µM 3.97E-5 TRP & mitochondrial translation 61 2.76E-7
18 SGTC_2058 5236698 4.97 133.0 µM 4.48E-5 13 3.34E-7
19 SGTC_2900 5328528 4.96 85.3 µM 4.67E-5 Golgi 14 3.58E-7
20 SGTC_831 k061-1017 4.93 217.0 µM 5.05E-5 translation 24 4.04E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.476 1.16E-188 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.464 2.49E-178 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.460 1.34E-175 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.457 3.48E-173 YPL078C ATP4 hom Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.452 8.98E-169 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.450 3.18E-167 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.449 2.40E-166 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.446 5.01E-164 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.437 2.06E-156 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.437 2.65E-156 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.435 7.92E-155 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.435 1.11E-154 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.434 3.40E-154 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.424 9.33E-147 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.421 4.42E-144 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci