HIPHOP chemogenomics database

YNL012W / SPO1

Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL012W / SPO1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL012W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1813	st051246	5.91	8.6 µM	2.97E-10	TSC3-RPN4	2	1.67E-9
2	SGTC_561	1550-0330	5.25	72.9 µM	1.87E-8		4	7.68E-8
3	SGTC_2268	7933382	4.44	153.8 µM	1.51E-6		25	4.41E-6
4	SGTC_3264	9137442	4.17	49.5 µM	5.81E-6		11	1.53E-5
5	SGTC_2223	6903751	3.93	107.6 µM	1.78E-5	superoxide	11	4.28E-5
6	SGTC_2165	5727197	3.79	32.1 µM	3.23E-5		37	7.40E-5
7	SGTC_420	mitomycin C	3.76	81.9 mM	3.70E-5		22	8.40E-5
8	SGTC_1192	1488-0095	3.67	21.4 µM	5.43E-5		22	1.20E-4
9	SGTC_1600	coumarin 106	3.52	71.1 µM	1.03E-4		37	2.16E-4
10	SGTC_1075	aripiprazole	3.49	15.2 µM	1.16E-4		47	2.41E-4
11	SGTC_3259	9138485	3.46	49.5 µM	1.32E-4		22	2.71E-4
12	SGTC_2264	7948757	3.45	110.8 µM	1.37E-4		30	2.80E-4
13	SGTC_43	0570-0105	3.42	72.5 µM	1.53E-4	ERG2	141	3.10E-4
14	SGTC_2848	9016370	3.42	26.0 µM	1.55E-4		49	3.14E-4
15	SGTC_1063	disulfiram	3.42	1.8 µM	1.55E-4		43	3.15E-4
16	SGTC_310	1273-0058	3.42	1.1 µM	1.57E-4	mitochondrial stress	301	3.17E-4
17	SGTC_3136	9095672	3.40	49.5 µM	1.64E-4		46	3.32E-4
18	SGTC_1690	st023502	3.37	41.2 µM	1.87E-4	calcium & mitochondrial duress	22	3.73E-4
19	SGTC_2401	5128683	3.37	200.0 µM	1.88E-4		61	3.76E-4
20	SGTC_2594	a-mangostin	3.37	100.0 µM	1.91E-4		56	3.81E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.103	2.66E-9	YKR015C_p	YKR015C_p	hom	Putative protein of unknown function
0.087	4.57E-7	YOR257W	CDC31	het	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.083	1.75E-6	YDR003W	RCR2	hom	Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.082	2.17E-6	YOR376W-A_p	YOR376W-A_p	hom	Putative protein of unknown function; identified by fungal homology and RT-PCR
0.081	2.66E-6	YMR083W	ADH3	hom	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
0.078	6.41E-6	YIR016W_p	YIR016W_p	hom	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.073	2.30E-5	YOR071C	NRT1	hom	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.073	2.50E-5	YJR078W	BNA2	hom	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.071	3.49E-5	YLR393W	ATP10	hom	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
0.071	3.91E-5	YGR136W	LSB1	hom	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.070	4.43E-5	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.070	4.76E-5	YPL173W	MRPL40	hom	Mitochondrial ribosomal protein of the large subunit
0.070	5.05E-5	YPR116W	RRG8	hom	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.070	5.39E-5	YPL064C	CWC27	hom	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.068	7.73E-5	YMR282C	AEP2	hom	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader