HIPHOP chemogenomics database

YNL027W / CRZ1

Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL027W / CRZ1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL027W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	17.50	100.0 µM	7.71E-74	redox potentiating	5	1.37E-68
2	SGTC_266	formosanin C	8.89	406.0 nM	1.17E-20	sphingolipid biosynthesis & PDR1	15	2.95E-19
3	SGTC_299	1273-0059	6.85	1.4 µM	5.15E-13		5	3.64E-12
4	SGTC_769	0302-0231	5.36	76.0 µM	1.22E-8		13	4.17E-8
5	SGTC_310	1273-0058	4.51	1.1 µM	1.33E-6	mitochondrial stress	210	3.24E-6
6	SGTC_2777	climbazole	4.02	1.5 µM	1.41E-5	iron homeostasis	47	2.90E-5
7	SGTC_467	ro 31-8220	3.99	72.8 µM	1.63E-5	calcium & mitochondrial duress	79	3.32E-5
8	SGTC_3331	9141060	3.73	2.0 µM	5.13E-5	cell wall	40	9.63E-5
9	SGTC_100	0086-0128	3.69	49.6 µM	6.10E-5	copper-dependent oxidative stress	61	1.13E-4
10	SGTC_757	1066-0008	3.64	322.0 µM	7.35E-5	Golgi	26	1.35E-4
11	SGTC_3212	9128307	3.51	49.5 µM	1.25E-4		66	2.21E-4
12	SGTC_1170	0310-0127	3.41	64.8 µM	1.91E-4		43	3.26E-4
13	SGTC_325	2810-4341	3.35	181.0 µM	2.42E-4	amide catabolism	18	4.07E-4
14	SGTC_2416	tofa	3.34	880.0 nM	2.47E-4	sphingolipid biosynthesis & PDR1	76	4.15E-4
15	SGTC_947	3447-0010	3.29	211.0 µM	3.01E-4		36	4.99E-4
16	SGTC_1718	roemerine	3.28	11.9 µM	3.15E-4	redox potentiating	92	5.21E-4
17	SGTC_455	paf C-16	3.26	10.0 µM	3.36E-4		52	5.53E-4
18	SGTC_909	3448-9333	3.26	149.0 µM	3.37E-4		37	5.53E-4
19	SGTC_2568	diosmetin	3.26	100.0 µM	3.45E-4		54	5.66E-4
20	SGTC_31	0508-1974	2.98	57.2 µM	9.37E-4		72	0.00143

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.415	1.69E-139	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.373	2.15E-111	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.355	3.81E-100	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.354	7.35E-100	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.340	1.69E-91	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.337	4.15E-90	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.319	2.29E-80	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.318	6.66E-80	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.309	3.49E-75	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.301	2.65E-71	YMR115W	MGR3	hom	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.296	9.74E-69	YLR206W	ENT2	hom	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.290	5.18E-66	YNL074C	MLF3	hom	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.286	2.22E-64	YGL178W	MPT5	hom	mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.286	2.32E-64	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.256	2.83E-51	YML102W	CAC2	hom	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription