YNL027W / CRZ1

Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL027W / CRZ1

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-3.06|P-value:7.86E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:2.98|P-value:9.37E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.69|P-value:6.10E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:8.89|P-value:1.17E-20 ID:SGTC_299|Compound:1273-0059|FD-Score:6.85|P-value:5.15E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:1.33E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.35|P-value:2.42E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.82|P-value:3.95E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.68|P-value:7.20E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.26|P-value:3.36E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.09|P-value:7.17E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.64|P-value:7.35E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.36|P-value:1.22E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.29|P-value:3.01E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.34|P-value:3.59E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.11|P-value:6.54E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.30|P-value:3.19E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_1798|Compound:st045719|FD-Score:2.97|P-value:9.85E-4 ID:SGTC_1911|Compound:st060208|FD-Score:2.97|P-value:9.78E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.10|P-value:6.71E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.20|P-value:4.73E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.34|P-value:2.47E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:17.50|P-value:7.71E-74 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.17|P-value:8.17E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:4.02|P-value:1.41E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.27|P-value:3.70E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.14|P-value:5.84E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.14|P-value:5.80E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.73|P-value:5.13E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.06|P-value:7.86E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:2.98|P-value:9.37E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.69|P-value:6.10E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:8.89|P-value:1.17E-20 ID:SGTC_299|Compound:1273-0059|FD-Score:6.85|P-value:5.15E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:1.33E-6 ID:SGTC_325|Compound:2810-4341|FD-Score:3.35|P-value:2.42E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-3.82|P-value:3.95E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.68|P-value:7.20E-5 ID:SGTC_455|Compound:paf C-16|FD-Score:3.26|P-value:3.36E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.99|P-value:1.63E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.09|P-value:7.17E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.64|P-value:7.35E-5 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.36|P-value:1.22E-8 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.80|P-value:4.29E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.26|P-value:3.37E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.29|P-value:3.01E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.34|P-value:3.59E-6 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.11|P-value:6.54E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.41|P-value:1.91E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.30|P-value:3.19E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_1798|Compound:st045719|FD-Score:2.97|P-value:9.85E-4 ID:SGTC_1911|Compound:st060208|FD-Score:2.97|P-value:9.78E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.10|P-value:6.71E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.20|P-value:4.73E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.34|P-value:2.47E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.29|P-value:3.40E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:17.50|P-value:7.71E-74 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.17|P-value:8.17E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:4.02|P-value:1.41E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.27|P-value:3.70E-4 ID:SGTC_2970|Compound:9090938|FD-Score:-3.14|P-value:5.84E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-3.14|P-value:5.80E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.51|P-value:1.25E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.73|P-value:5.13E-5

Top fitness defect scores for YNL027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 17.50 100.0 µM 7.71E-74 redox potentiating 5 1.37E-68
2 SGTC_266 formosanin C 8.89 406.0 nM 1.17E-20 sphingolipid biosynthesis & PDR1 15 2.95E-19
3 SGTC_299 1273-0059 6.85 1.4 µM 5.15E-13 5 3.64E-12
4 SGTC_769 0302-0231 5.36 76.0 µM 1.22E-8 13 4.17E-8
5 SGTC_310 1273-0058 4.51 1.1 µM 1.33E-6 mitochondrial stress 210 3.24E-6
6 SGTC_2777 climbazole 4.02 1.5 µM 1.41E-5 iron homeostasis 47 2.90E-5
7 SGTC_467 ro 31-8220 3.99 72.8 µM 1.63E-5 calcium & mitochondrial duress 79 3.32E-5
8 SGTC_3331 9141060 3.73 2.0 µM 5.13E-5 cell wall 40 9.63E-5
9 SGTC_100 0086-0128 3.69 49.6 µM 6.10E-5 copper-dependent oxidative stress 61 1.13E-4
10 SGTC_757 1066-0008 3.64 322.0 µM 7.35E-5 Golgi 26 1.35E-4
11 SGTC_3212 9128307 3.51 49.5 µM 1.25E-4 66 2.21E-4
12 SGTC_1170 0310-0127 3.41 64.8 µM 1.91E-4 43 3.26E-4
13 SGTC_325 2810-4341 3.35 181.0 µM 2.42E-4 amide catabolism 18 4.07E-4
14 SGTC_2416 tofa 3.34 880.0 nM 2.47E-4 sphingolipid biosynthesis & PDR1 76 4.15E-4
15 SGTC_947 3447-0010 3.29 211.0 µM 3.01E-4 36 4.99E-4
16 SGTC_1718 roemerine 3.28 11.9 µM 3.15E-4 redox potentiating 92 5.21E-4
17 SGTC_455 paf C-16 3.26 10.0 µM 3.36E-4 52 5.53E-4
18 SGTC_909 3448-9333 3.26 149.0 µM 3.37E-4 37 5.53E-4
19 SGTC_2568 diosmetin 3.26 100.0 µM 3.45E-4 54 5.66E-4
20 SGTC_31 0508-1974 2.98 57.2 µM 9.37E-4 72 0.00143

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.415 1.69E-139 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.373 2.15E-111 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.355 3.81E-100 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.354 7.35E-100 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.340 1.69E-91 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.337 4.15E-90 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.319 2.29E-80 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.318 6.66E-80 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.309 3.49E-75 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.301 2.65E-71 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.296 9.74E-69 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.290 5.18E-66 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.286 2.22E-64 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.286 2.32E-64 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.256 2.83E-51 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription