YNL031C / HHT2

Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL031C / HHT2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.00|P-value:5.47E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.81|P-value:1.68E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:3.46E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.40|P-value:1.08E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.08|P-value:4.07E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.17|P-value:2.87E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.81|P-value:1.66E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:3.02E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.09|P-value:3.93E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.03|P-value:4.87E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.37|P-value:1.20E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:4.14|P-value:3.25E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.24|P-value:2.10E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:5.10|P-value:1.42E-8 ID:SGTC_988|Compound:1497-1057|FD-Score:3.09|P-value:3.85E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.92|P-value:7.51E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.11|P-value:3.52E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.07|P-value:4.68E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:2.84|P-value:9.88E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.90|P-value:1.09E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.77|P-value:2.00E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.39|P-value:1.15E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.64|P-value:3.68E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.93|P-value:7.28E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.98|P-value:5.93E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.09|P-value:4.21E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.42|P-value:9.96E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.16|P-value:2.98E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.32|P-value:1.32E-6 ID:SGTC_2316|Compound:5844804|FD-Score:2.92|P-value:7.36E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.03|P-value:4.79E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.84|P-value:1.47E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.06|P-value:4.41E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:2.84|P-value:9.95E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.90|P-value:7.94E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.82|P-value:1.62E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.13|P-value:3.34E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.90|P-value:1.11E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.17|P-value:2.86E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.28|P-value:4.57E-9 ID:SGTC_2940|Compound:9060638|FD-Score:-3.07|P-value:4.08E-4 ID:SGTC_3208|Compound:9114115|FD-Score:2.84|P-value:9.90E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.00|P-value:5.47E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.81|P-value:1.68E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.66|P-value:3.46E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:2.91|P-value:7.79E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.40|P-value:1.08E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.08|P-value:4.07E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.17|P-value:2.87E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.18|P-value:2.73E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.81|P-value:1.66E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:3.15|P-value:3.02E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.09|P-value:3.93E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.03|P-value:4.87E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:2.87|P-value:9.03E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.37|P-value:1.20E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:4.14|P-value:3.25E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.24|P-value:2.10E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:5.10|P-value:1.42E-8 ID:SGTC_988|Compound:1497-1057|FD-Score:3.09|P-value:3.85E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.92|P-value:7.51E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.11|P-value:3.52E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.07|P-value:4.68E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:2.84|P-value:9.88E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.90|P-value:1.09E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:-3.77|P-value:2.00E-5 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.39|P-value:1.15E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.64|P-value:3.68E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.93|P-value:7.28E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.98|P-value:5.93E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.09|P-value:4.21E-6 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.42|P-value:9.96E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.17|P-value:2.80E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.16|P-value:2.98E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:4.32|P-value:1.32E-6 ID:SGTC_2316|Compound:5844804|FD-Score:2.92|P-value:7.36E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.03|P-value:4.79E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.84|P-value:1.47E-5 ID:SGTC_2474|Compound:5321570|FD-Score:3.06|P-value:4.41E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:2.84|P-value:9.95E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-2.90|P-value:7.94E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.82|P-value:1.62E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.13|P-value:3.34E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.90|P-value:1.11E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.17|P-value:2.86E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.28|P-value:4.57E-9 ID:SGTC_2940|Compound:9060638|FD-Score:-3.07|P-value:4.08E-4 ID:SGTC_3208|Compound:9114115|FD-Score:2.84|P-value:9.90E-4

Top fitness defect scores for YNL031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2804 7954240 5.28 19.5 µM 4.57E-9 9 6.48E-8
2 SGTC_919 tnp00227 5.10 403.6 nM 1.42E-8 RNA pol III & RNase P/MRP 12 1.70E-7
3 SGTC_2236 dapsone 4.32 200.0 µM 1.32E-6 5 7.95E-6
4 SGTC_775 4577-0580 4.14 57.3 µM 3.25E-6 8 1.70E-5
5 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.09 66.5 µM 4.21E-6 17 2.13E-5
6 SGTC_1103 duloxetine 4.07 36.1 µM 4.68E-6 27 2.33E-5
7 SGTC_2759 disulfiram 3.90 3.4 µM 1.11E-5 35 4.84E-5
8 SGTC_2441 5730946 3.84 39.1 µM 1.47E-5 22 6.16E-5
9 SGTC_2738 aclarubicin 3.82 5.5 µM 1.62E-5 RNA pol III & RNase P/MRP 11 6.70E-5
10 SGTC_78 0336-0123 3.81 156.8 µM 1.68E-5 25 6.89E-5
11 SGTC_136 0097-0015 3.66 404.5 µM 3.46E-5 60S ribosome export 27 1.28E-4
12 SGTC_1378 2093-0007 3.64 380.0 nM 3.68E-5 29 1.34E-4
13 SGTC_1668 st014914 3.42 51.6 µM 9.96E-5 RPP1 & pyrimidine depletion 10 3.14E-4
14 SGTC_183 3914-0051 3.40 30.6 µM 1.08E-4 60S ribosome export 41 3.37E-4
15 SGTC_1284 0929-0043 3.39 16.0 µM 1.15E-4 47 3.54E-4
16 SGTC_853 0419-0306 3.24 21.0 µM 2.10E-4 37 5.92E-4
17 SGTC_360 0957-0399 3.18 1.0 µM 2.73E-4 cell wall 83 7.41E-4
18 SGTC_2017 5132927 3.17 60.6 µM 2.80E-4 65 7.59E-4
19 SGTC_2798 7813637 3.17 45.5 µM 2.86E-4 66 7.72E-4
20 SGTC_344 k064-0035 3.17 6.4 µM 2.87E-4 60S ribosome export 54 7.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.51E-10 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.104 1.54E-9 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.099 8.42E-9 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.097 2.04E-8 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.092 9.31E-8 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.089 2.22E-7 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.086 5.56E-7 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.086 7.00E-7 YER143W DDI1 hom DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
0.085 7.58E-7 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.083 1.35E-6 YPL114W_d YPL114W_d hom Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
0.082 1.78E-6 YML082W_p YML082W_p hom Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
0.080 3.59E-6 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.078 5.63E-6 YBR092C PHO3 hom Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
0.078 5.66E-6 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.076 9.38E-6 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs