YNL039W / BDP1

Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL039W / BDP1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.39|P-value:4.85E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.91|P-value:8.45E-7 ID:SGTC_233|Compound:rapamycin|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.47|P-value:3.60E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.78|P-value:1.06E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.33|P-value:5.53E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.30|P-value:6.05E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.37|P-value:5.10E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.89|P-value:9.21E-7 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.19|P-value:9.31E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.89|P-value:6.79E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.37|P-value:4.76E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.61|P-value:3.14E-6 ID:SGTC_2319|Compound:6033012|FD-Score:3.42|P-value:4.24E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-5.37|P-value:7.38E-8 ID:SGTC_2326|Compound:6164455|FD-Score:3.27|P-value:7.12E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.23|P-value:7.64E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.39|P-value:4.85E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.91|P-value:8.45E-7 ID:SGTC_233|Compound:rapamycin|FD-Score:3.32|P-value:6.04E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.47|P-value:3.60E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.78|P-value:1.06E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:-3.33|P-value:5.53E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.30|P-value:6.05E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:3.37|P-value:5.10E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.89|P-value:9.21E-7 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.19|P-value:9.31E-4 ID:SGTC_1882|Compound:5615643|FD-Score:-3.89|P-value:6.79E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-3.37|P-value:4.76E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.61|P-value:3.14E-6 ID:SGTC_2319|Compound:6033012|FD-Score:3.42|P-value:4.24E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-5.37|P-value:7.38E-8 ID:SGTC_2326|Compound:6164455|FD-Score:3.27|P-value:7.12E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.23|P-value:7.64E-4

Top fitness defect scores for YNL039W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_77 0828-0286 4.91 12.5 µM 8.45E-7 TSC3-RPN4 3 4.60E-7 0.61
2 SGTC_1045 1348-1485 4.89 165.0 µM 9.21E-7 3 5.03E-7 1.05
3 SGTC_301 4119-0100 3.47 24.5 µM 3.60E-4 NEO1 13 2.60E-4 0.45
4 SGTC_2319 6033012 3.42 152.6 µM 4.24E-4 tubulin folding & SWR complex 7 3.09E-4 0.18
5 SGTC_6 0844-0013 3.39 19.8 µM 4.85E-4 17 3.55E-4 0.00
6 SGTC_877 0771-0151 3.37 33.1 µM 5.10E-4 3 3.75E-4 0.03
7 SGTC_233 rapamycin 3.32 362.0 pM 6.04E-4 4 4.47E-4 0.40
8 SGTC_2326 6164455 3.27 177.6 µM 7.12E-4 mitochondrial processes 22 5.31E-4 0.14
9 SGTC_1458 k015-0034 3.19 6.3 µM 9.31E-4 8 7.03E-4 0.15
10 SGTC_521 r062-0005 3.11 13.8 µM 0.00124 8 9.44E-4 0.07
11 SGTC_2321 7390090 3.09 138.8 µM 0.00131 12 0.00101 0.31
12 SGTC_2163 5671233 3.09 125.0 µM 0.00132 27 0.00101 0.04
13 SGTC_995 3931-2021 3.03 34.6 µM 0.00156 RPP1 & pyrimidine depletion 14 0.00121 0.03
14 SGTC_1951 sophoraflavanone G 3.03 9.2 µM 0.00159 RNA processing & uracil transport 14 0.00123 0.12
15 SGTC_860 0443-0016 3.00 25.1 µM 0.00174 17 0.00135 0.08
16 SGTC_2072 5231554 2.98 129.0 µM 0.00187 13 0.00146 0.01
17 SGTC_2945 9067681 2.95 61.8 µM 0.00205 16 0.00161 0.02
18 SGTC_1016 4226-1401 2.88 38.0 µM 0.00249 RNA pol III & RNase P/MRP 30 0.00197 0.03
19 SGTC_931 2812-0076 2.84 566.0 µM 0.00285 23 0.00227 0.03
20 SGTC_2317 5986382 2.70 200.0 µM 0.00428 15 0.00347 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.42E-16 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.121 2.15E-12 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.119 4.61E-12 YOL093W TRM10 hom tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress
0.114 3.11E-11 YOR373W NUD1 het Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
0.102 2.68E-9 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.097 2.04E-8 YLR366W_d YLR366W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
0.096 2.15E-8 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.094 5.76E-8 YOR107W RGS2 hom Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
0.093 6.41E-8 YPL081W RPS9A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication
0.092 9.24E-8 YKR011C YKR011C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress
0.090 1.71E-7 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.090 1.74E-7 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.089 2.09E-7 YGR239C PEX21 hom Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress
0.087 3.94E-7 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.087 4.26E-7 YLR445W GMC2 hom Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor