YNL042W / BOP3

Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL042W / BOP3

Click on Significant Values for Screen Details ID:SGTC_305|Compound:1682-2595|FD-Score:2.94|P-value:6.58E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.18|P-value:2.57E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-5.31|P-value:5.38E-9 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.74|P-value:2.26E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:5.43|P-value:1.72E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.01|P-value:6.20E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.14|P-value:3.02E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.39|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.95|P-value:5.08E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.49|P-value:6.88E-7 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.99|P-value:6.85E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.05|P-value:5.30E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.72|P-value:2.48E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.75|P-value:2.19E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.40|P-value:1.03E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.54|P-value:7.29E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.03|P-value:5.91E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.17|P-value:2.69E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.99|P-value:5.49E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.25|P-value:1.92E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.92|P-value:8.62E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.52|P-value:6.23E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.96|P-value:1.03E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.10|P-value:4.43E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.71|P-value:3.41E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.47|P-value:9.88E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.52|P-value:6.25E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.74|P-value:2.94E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:2.94|P-value:6.58E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.18|P-value:2.57E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-5.31|P-value:5.38E-9 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.74|P-value:2.26E-5 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:5.43|P-value:1.72E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.01|P-value:6.20E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.14|P-value:3.02E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.39|P-value:1.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.95|P-value:5.08E-8 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-4.49|P-value:6.88E-7 ID:SGTC_1355|Compound:1499-0035|FD-Score:-2.99|P-value:6.85E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.05|P-value:5.30E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.72|P-value:2.48E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.75|P-value:2.19E-5 ID:SGTC_1756|Compound:st041558|FD-Score:3.40|P-value:1.03E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.54|P-value:7.29E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.03|P-value:5.91E-4 ID:SGTC_2076|Compound:5212012|FD-Score:3.17|P-value:2.69E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.99|P-value:5.49E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.25|P-value:1.92E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.92|P-value:8.62E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.52|P-value:6.23E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.31|P-value:1.89E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.04|P-value:5.50E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.96|P-value:1.03E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.10|P-value:4.43E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.71|P-value:3.41E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.47|P-value:9.88E-5 ID:SGTC_2942|Compound:9052777|FD-Score:3.52|P-value:6.25E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.74|P-value:2.94E-5

Top fitness defect scores for YNL042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_479 n-linoleoylglycine 5.43 10.0 µM 1.72E-9 2 2.77E-8
2 SGTC_1587 estradiol valerate 3.75 56.1 µM 2.19E-5 14 8.91E-5
3 SGTC_477 mead ethanolamide 3.74 10.0 µM 2.26E-5 5 9.13E-5
4 SGTC_1586 deoxycorticosterone acetate 3.72 53.7 µM 2.48E-5 16 9.88E-5
5 SGTC_2514 salinomycin 3.52 42.7 µM 6.23E-5 71 2.17E-4
6 SGTC_2942 9052777 3.52 62.2 µM 6.25E-5 51 2.18E-4
7 SGTC_1756 st041558 3.40 35.5 µM 1.03E-4 19 3.34E-4
8 SGTC_2110 5483698 3.25 200.0 µM 1.92E-4 TSC3-RPN4 46 5.70E-4
9 SGTC_1763 st044482 3.22 94.5 µM 2.19E-4 copper-dependent oxidative stress 39 6.39E-4
10 SGTC_406 estrone 3.18 100.0 µM 2.57E-4 29 7.31E-4
11 SGTC_2076 5212012 3.17 200.0 µM 2.69E-4 17 7.60E-4
12 SGTC_1008 4106-0037 3.14 6.0 µM 3.02E-4 PDR1 43 8.40E-4
13 SGTC_2080 5212524 2.99 12.4 µM 5.49E-4 copper-dependent oxidative stress 46 0.00140
14 SGTC_305 1682-2595 2.94 20.8 µM 6.58E-4 RNA processing & uracil transport 59 0.00164
15 SGTC_1330 1469-0054 2.70 61.8 µM 0.00156 iron homeostasis 78 0.00342
16 SGTC_2989 9073649 2.67 71.4 µM 0.00173 135 0.00375
17 SGTC_485 niflumic acid 2.64 177.0 µM 0.00198 62 0.00420
18 SGTC_2823 7987624 2.61 58.4 µM 0.00216 137 0.00453
19 SGTC_322 k048-0136 2.58 19.3 µM 0.00240 RSC & ERG11 79 0.00497
20 SGTC_3313 9133968 2.57 57.0 µM 0.00248 71 0.00510

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 7.84E-44 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 5.33E-35 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.204 7.40E-33 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.180 9.23E-26 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.179 1.94E-25 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.177 6.37E-25 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.176 8.08E-25 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.172 9.69E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.168 1.10E-22 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.168 1.45E-22 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.167 1.79E-22 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.167 2.62E-22 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.166 4.54E-22 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164 1.40E-21 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.163 1.99E-21 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7