YNL042W-B_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL042W-B / YNL042W-B

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:3.56E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:1.11E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.91|P-value:4.17E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:4.59|P-value:6.59E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.10|P-value:1.65E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.94|P-value:3.70E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.47|P-value:3.02E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.27|P-value:7.78E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.25E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.68|P-value:9.55E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.05|P-value:2.10E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.75|P-value:7.34E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.40|P-value:2.11E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.37|P-value:5.28E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:1.14E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.03|P-value:2.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.54|P-value:2.35E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.37|P-value:5.27E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.92|P-value:3.57E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.91|P-value:3.53E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.60|P-value:1.58E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.08|P-value:1.83E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.10|P-value:1.66E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.67|P-value:9.84E-4 ID:SGTC_2104|Compound:5389443|FD-Score:2.71|P-value:9.36E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.97|P-value:3.21E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.56|P-value:1.88E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.42|P-value:4.33E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.03|P-value:1.59E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-4.22|P-value:5.17E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.23|P-value:1.04E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.54|P-value:2.34E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.02|P-value:2.60E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.27|P-value:4.64E-7 ID:SGTC_2848|Compound:9016370|FD-Score:2.98|P-value:3.16E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.91|P-value:3.08E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.11|P-value:1.77E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.24|P-value:9.94E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:3.56E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.22|P-value:1.11E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.91|P-value:4.17E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:4.59|P-value:6.59E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.10|P-value:1.65E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:2.94|P-value:3.70E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.47|P-value:3.02E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.27|P-value:7.78E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.25E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.68|P-value:9.55E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.05|P-value:2.10E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.75|P-value:7.34E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.40|P-value:2.11E-7 ID:SGTC_822|Compound:1487-0950|FD-Score:2.87|P-value:4.85E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.37|P-value:5.28E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:1.14E-7 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.03|P-value:2.27E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.54|P-value:2.35E-5 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.37|P-value:5.27E-5 ID:SGTC_1341|Compound:1486-1360|FD-Score:-2.92|P-value:3.57E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.91|P-value:3.53E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.60|P-value:1.58E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.72|P-value:9.07E-4 ID:SGTC_2008|Compound:4012253|FD-Score:-3.08|P-value:1.83E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.10|P-value:1.66E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.67|P-value:9.84E-4 ID:SGTC_2104|Compound:5389443|FD-Score:2.71|P-value:9.36E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.97|P-value:3.21E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.56|P-value:1.88E-5 ID:SGTC_2340|Compound:7987427|FD-Score:3.42|P-value:4.33E-5 ID:SGTC_2352|Compound:9027995|FD-Score:-4.03|P-value:1.59E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-4.22|P-value:5.17E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.23|P-value:1.04E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.54|P-value:2.34E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.02|P-value:2.60E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.27|P-value:4.64E-7 ID:SGTC_2848|Compound:9016370|FD-Score:2.98|P-value:3.16E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.91|P-value:3.08E-6 ID:SGTC_3048|Compound:9093155|FD-Score:3.11|P-value:1.77E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.24|P-value:9.94E-5

Top fitness defect scores for YNL042W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_281 1672-3440 4.59 14.9 µM 6.59E-8 Golgi 4 2.24E-6
2 SGTC_798 1287-0182 4.40 476.0 µM 2.11E-7 13 5.44E-6
3 SGTC_2831 7999036 4.27 19.5 µM 4.64E-7 34 9.93E-6
4 SGTC_1364 1653-0028 3.91 37.6 µM 3.53E-6 23 4.67E-5
5 SGTC_669 0108-0021 3.67 26.2 µM 1.25E-5 fatty acid desaturase (OLE1) 98 1.22E-4
6 SGTC_2764 methyldopa 3.54 94.7 µM 2.34E-5 26 1.98E-4
7 SGTC_1246 0422-0085 3.54 105.0 µM 2.35E-5 49 1.99E-4
8 SGTC_2340 7987427 3.42 183.4 µM 4.33E-5 58 3.18E-4
9 SGTC_1270 0831-1170 3.37 17.3 µM 5.27E-5 24 3.69E-4
10 SGTC_996 3970-0799 3.37 1.8 µM 5.28E-5 126 3.70E-4
11 SGTC_3315 9136395 3.24 68.5 µM 9.94E-5 27 6.01E-4
12 SGTC_2763 lisinopril 3.23 49.3 µM 1.04E-4 25 6.20E-4
13 SGTC_279 1273-0055 3.22 2.9 µM 1.11E-4 azole & statin 66 6.52E-4
14 SGTC_3048 9093155 3.11 49.5 µM 1.77E-4 22 9.36E-4
15 SGTC_2794 7785382 3.02 27.3 µM 2.60E-4 92 0.00126
16 SGTC_2848 9016370 2.98 26.0 µM 3.16E-4 75 0.00146
17 SGTC_2130 NSC 7 2.97 2.5 µM 3.21E-4 copper-dependent oxidative stress 91 0.00148
18 SGTC_236 1509-0011 2.95 5.3 µM 3.56E-4 460 0.00160
19 SGTC_513 4245-1575 2.94 41.7 µM 3.70E-4 unfolded protein response 198 0.00165
20 SGTC_280 3448-3607 2.91 3.0 µM 4.17E-4 60S ribosome export 37 0.00181

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 4.89E-60 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.249 1.33E-48 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.222 6.91E-39 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.204 6.36E-33 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.198 5.85E-31 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.197 9.11E-31 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.188 3.50E-28 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.188 4.11E-28 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.185 2.24E-27 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.184 5.51E-27 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.178 2.81E-25 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.177 5.55E-25 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.170 3.56E-23 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.170 4.55E-23 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.169 7.06E-23 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function