YNL043C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL043C / YNL043C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.15|P-value:9.37E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.06|P-value:2.91E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.93|P-value:5.27E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:-4.20|P-value:1.49E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:4.44|P-value:5.72E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.20|P-value:7.73E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.24|P-value:6.75E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-4.96|P-value:4.14E-7 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.11|P-value:2.21E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.84|P-value:7.73E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:7.92|P-value:2.17E-15 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.92|P-value:5.56E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.31|P-value:7.59E-8 ID:SGTC_1945|Compound:st075991|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.30|P-value:5.57E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.24|P-value:6.52E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.24|P-value:6.71E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.66|P-value:1.40E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.96|P-value:4.55E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.78|P-value:1.12E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.77|P-value:9.97E-12 ID:SGTC_2792|Compound:7535235|FD-Score:13.70|P-value:2.52E-42 ID:SGTC_2799|Compound:7812892|FD-Score:4.29|P-value:1.11E-5 ID:SGTC_3014|Compound:9081533|FD-Score:-3.92|P-value:4.86E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.84|P-value:7.20E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.33|P-value:4.95E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.15|P-value:9.37E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.75|P-value:1.06E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.06|P-value:2.91E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.68|P-value:1.36E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:4.93|P-value:5.27E-7 ID:SGTC_740|Compound:k014-0057|FD-Score:-4.20|P-value:1.49E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:4.44|P-value:5.72E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:3.20|P-value:7.73E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:3.49|P-value:2.79E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.24|P-value:6.75E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.38|P-value:4.09E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.53|P-value:2.45E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-4.96|P-value:4.14E-7 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.32|P-value:5.21E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:-4.11|P-value:2.21E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-4.84|P-value:7.73E-7 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:7.92|P-value:2.17E-15 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.64|P-value:1.58E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.92|P-value:5.56E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.31|P-value:7.59E-8 ID:SGTC_1945|Compound:st075991|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.30|P-value:5.57E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-3.24|P-value:6.52E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.24|P-value:6.71E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.66|P-value:1.40E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.96|P-value:4.55E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:4.78|P-value:1.12E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.77|P-value:9.97E-12 ID:SGTC_2792|Compound:7535235|FD-Score:13.70|P-value:2.52E-42 ID:SGTC_2799|Compound:7812892|FD-Score:4.29|P-value:1.11E-5 ID:SGTC_3014|Compound:9081533|FD-Score:-3.92|P-value:4.86E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.84|P-value:7.20E-5 ID:SGTC_3325|Compound:9138760|FD-Score:3.33|P-value:4.95E-4

Top fitness defect scores for YNL043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2792 7535235 13.70 81.8 µM 2.52E-42 fatty acid desaturase (OLE1) 1 4.22E-43
2 SGTC_1528 arabinosylhypoxanthine 7.92 74.6 µM 2.17E-15 2 1.15E-15
3 SGTC_2688 kanamycin b 6.77 96.7 µM 9.97E-12 calcium & mitochondrial duress 114 6.22E-12
4 SGTC_1789 tunicamycin 5.31 25.0 nM 7.59E-8 unfolded protein response 26 5.61E-8
5 SGTC_735 3076-0345 4.93 636.0 µM 5.27E-7 12 4.04E-7
6 SGTC_1645 Cervolide 4.92 78.0 µM 5.56E-7 1 4.27E-7
7 SGTC_2686 alizarin 4.78 95.4 µM 1.12E-6 RPP1 & pyrimidine depletion 17 8.68E-7
8 SGTC_750 4073-0104 4.44 132.0 µM 5.72E-6 6 4.59E-6
9 SGTC_2799 7812892 4.29 81.8 µM 1.11E-5 superoxide 24 8.99E-6
10 SGTC_353 1988-1175 4.06 58.3 µM 2.91E-5 unfolded protein response 24 2.41E-5
11 SGTC_2445 5742597 3.96 35.6 µM 4.55E-5 37 3.80E-5
12 SGTC_3191 9110352 3.84 49.5 µM 7.20E-5 12 6.06E-5
13 SGTC_245 methotrexate 3.75 289.6 µM 1.06E-4 50 8.95E-5
14 SGTC_1605 st000082 3.74 49.1 µM 1.07E-4 60S ribosome export 21 9.04E-5
15 SGTC_473 2-arachidonoylglycerol 3.68 10.0 µM 1.36E-4 23 1.16E-4
16 SGTC_1597 7-benzyloxygramine 3.64 47.5 µM 1.58E-4 calcium & mitochondrial duress 143 1.35E-4
17 SGTC_3037 9091026 3.55 49.5 µM 2.21E-4 NEO1-PIK1 147 1.90E-4
18 SGTC_1137 ixabepilone 3.53 100.0 µM 2.45E-4 44 2.11E-4
19 SGTC_868 0527-0199 3.49 213.0 µM 2.79E-4 fatty acid desaturase (OLE1) 42 2.41E-4
20 SGTC_1125 tnp00248 3.38 1.3 µM 4.09E-4 62 3.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 9.82E-23 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.162 3.41E-21 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.156 1.16E-19 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.139 5.16E-16 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.138 9.91E-16 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.134 6.24E-15 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.134 7.25E-15 YKL091C YKL091C hom Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study
0.131 2.73E-14 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.131 3.16E-14 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.129 6.38E-14 YMR142C RPL13B hom Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication
0.128 9.19E-14 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.123 7.98E-13 YOL031C SIL1 hom Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.122 1.40E-12 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.121 2.03E-12 YGL078C DBP3 hom RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
0.119 5.13E-12 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins