YNL044W / YIP3

Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL044W / YIP3

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.94|P-value:1.96E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.21|P-value:4.91E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.94|P-value:1.96E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.62|P-value:7.04E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.18|P-value:6.41E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.07|P-value:6.76E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.02|P-value:8.28E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.05|P-value:1.19E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.35|P-value:2.32E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:2.98|P-value:9.59E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.22|P-value:3.92E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.67|P-value:5.44E-7 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.97|P-value:9.77E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.05|P-value:6.68E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.81|P-value:3.47E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.13|P-value:5.42E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.54|P-value:1.09E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.00|P-value:8.83E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.03|P-value:7.95E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.05|P-value:8.29E-14 ID:SGTC_2370|Compound:9071495|FD-Score:3.45|P-value:1.58E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.12|P-value:5.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.10|P-value:5.50E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.02|P-value:1.38E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.11|P-value:8.83E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.29|P-value:2.69E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.22|P-value:3.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.33|P-value:2.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.52|P-value:3.90E-9 ID:SGTC_2967|Compound:9089538|FD-Score:4.86|P-value:1.95E-7 ID:SGTC_3037|Compound:9091026|FD-Score:4.31|P-value:3.38E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.47|P-value:1.45E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.41E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.28|P-value:2.80E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.21|P-value:3.61E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.29|P-value:3.21E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.94|P-value:1.96E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.21|P-value:4.91E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.94|P-value:1.96E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.62|P-value:7.04E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.18|P-value:6.41E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.07|P-value:6.76E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.02|P-value:8.28E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.05|P-value:1.19E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.35|P-value:2.32E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:2.98|P-value:9.59E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.22|P-value:3.92E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.42|P-value:1.79E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.67|P-value:5.44E-7 ID:SGTC_1417|Compound:3966-0327|FD-Score:2.97|P-value:9.77E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.05|P-value:6.68E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.81|P-value:3.47E-5 ID:SGTC_1607|Compound:st000305|FD-Score:3.13|P-value:5.42E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.54|P-value:1.09E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.00|P-value:8.83E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-3.12|P-value:5.18E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.03|P-value:7.95E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.05|P-value:8.29E-14 ID:SGTC_2370|Compound:9071495|FD-Score:3.45|P-value:1.58E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.12|P-value:5.13E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.10|P-value:5.50E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.02|P-value:1.38E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.11|P-value:8.83E-6 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.29|P-value:2.69E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.22|P-value:3.50E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.34|P-value:2.44E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.33|P-value:2.60E-4 ID:SGTC_2896|Compound:9052656|FD-Score:5.52|P-value:3.90E-9 ID:SGTC_2967|Compound:9089538|FD-Score:4.86|P-value:1.95E-7 ID:SGTC_3037|Compound:9091026|FD-Score:4.31|P-value:3.38E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.47|P-value:1.45E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.19|P-value:4.41E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.28|P-value:2.80E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.21|P-value:3.61E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-4.29|P-value:3.21E-6

Top fitness defect scores for YNL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2249 haloperidol 7.05 116.4 µM 8.29E-14 ergosterol depletion effects on membrane 32 8.82E-13
2 SGTC_2896 9052656 5.52 71.4 µM 3.90E-9 endomembrane recycling 45 1.66E-8
3 SGTC_2967 9089538 4.86 49.9 µM 1.95E-7 13 5.98E-7
4 SGTC_942 3253-1115 4.67 227.0 µM 5.44E-7 12 1.53E-6
5 SGTC_3037 9091026 4.31 49.5 µM 3.38E-6 NEO1-PIK1 104 8.16E-6
6 SGTC_403 arphamenine a 4.18 50.0 µM 6.41E-6 60S ribosome export 17 1.47E-5
7 SGTC_2474 5321570 4.11 43.3 µM 8.83E-6 9 1.97E-5
8 SGTC_808 0711-0032 4.05 135.0 µM 1.19E-5 11 2.60E-5
9 SGTC_2466 5983409 4.02 37.1 µM 1.38E-5 16 2.96E-5
10 SGTC_146 3448-8650 3.94 53.1 µM 1.96E-5 NEO1-PIK1 139 4.09E-5
11 SGTC_127 0180-0333 3.94 59.1 µM 1.96E-5 mitochondrial response to ROS 41 4.10E-5
12 SGTC_1597 7-benzyloxygramine 3.81 47.5 µM 3.47E-5 calcium & mitochondrial duress 131 6.91E-5
13 SGTC_1736 st036774 3.54 51.0 µM 1.09E-4 48 1.98E-4
14 SGTC_3217 9129673 3.47 49.5 µM 1.45E-4 62 2.57E-4
15 SGTC_2370 9071495 3.45 200.0 µM 1.58E-4 mitochondrial processes 36 2.79E-4
16 SGTC_69 0096-0274 3.44 206.7 µM 1.67E-4 mitochondrial processes 71 2.92E-4
17 SGTC_870 0573-2213 3.42 57.6 µM 1.79E-4 ERG2 37 3.12E-4
18 SGTC_839 0122-0028 3.35 230.0 µM 2.32E-4 RSC complex & mRNA processing 62 3.97E-4
19 SGTC_2688 kanamycin b 3.34 96.7 µM 2.44E-4 calcium & mitochondrial duress 467 4.14E-4
20 SGTC_2797 7859098 3.33 81.8 µM 2.60E-4 52 4.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.21E-26 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.156 9.06E-20 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152 1.13E-18 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151 1.34E-18 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.151 1.66E-18 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.150 2.24E-18 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.146 1.98E-17 YPL176C TRE1 hom Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication
0.142 1.40E-16 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.139 7.37E-16 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.138 1.15E-15 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.133 8.96E-15 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.128 1.06E-13 YOL159C YOL159C hom Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
0.125 3.76E-13 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.123 7.70E-13 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.122 1.27E-12 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress