HIPHOP chemogenomics database

YNL044W / YIP3

Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL044W / YIP3

Click on Significant Values for Screen Details

Top fitness defect scores for YNL044W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2249	haloperidol	7.05	116.4 µM	8.29E-14	ergosterol depletion effects on membrane	32	8.82E-13
2	SGTC_2896	9052656	5.52	71.4 µM	3.90E-9	endomembrane recycling	45	1.66E-8
3	SGTC_2967	9089538	4.86	49.9 µM	1.95E-7		13	5.98E-7
4	SGTC_942	3253-1115	4.67	227.0 µM	5.44E-7		12	1.53E-6
5	SGTC_3037	9091026	4.31	49.5 µM	3.38E-6	NEO1-PIK1	104	8.16E-6
6	SGTC_403	arphamenine a	4.18	50.0 µM	6.41E-6	60S ribosome export	17	1.47E-5
7	SGTC_2474	5321570	4.11	43.3 µM	8.83E-6		9	1.97E-5
8	SGTC_808	0711-0032	4.05	135.0 µM	1.19E-5		11	2.60E-5
9	SGTC_2466	5983409	4.02	37.1 µM	1.38E-5		16	2.96E-5
10	SGTC_146	3448-8650	3.94	53.1 µM	1.96E-5	NEO1-PIK1	139	4.09E-5
11	SGTC_127	0180-0333	3.94	59.1 µM	1.96E-5	mitochondrial response to ROS	41	4.10E-5
12	SGTC_1597	7-benzyloxygramine	3.81	47.5 µM	3.47E-5	calcium & mitochondrial duress	131	6.91E-5
13	SGTC_1736	st036774	3.54	51.0 µM	1.09E-4		48	1.98E-4
14	SGTC_3217	9129673	3.47	49.5 µM	1.45E-4		62	2.57E-4
15	SGTC_2370	9071495	3.45	200.0 µM	1.58E-4	mitochondrial processes	36	2.79E-4
16	SGTC_69	0096-0274	3.44	206.7 µM	1.67E-4	mitochondrial processes	71	2.92E-4
17	SGTC_870	0573-2213	3.42	57.6 µM	1.79E-4	ERG2	37	3.12E-4
18	SGTC_839	0122-0028	3.35	230.0 µM	2.32E-4	RSC complex & mRNA processing	62	3.97E-4
19	SGTC_2688	kanamycin b	3.34	96.7 µM	2.44E-4	calcium & mitochondrial duress	467	4.14E-4
20	SGTC_2797	7859098	3.33	81.8 µM	2.60E-4		52	4.40E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.183	1.21E-26	YJR075W	HOC1	hom	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.156	9.06E-20	YLR171W_d	YLR171W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.152	1.13E-18	YNL293W	MSB3	hom	Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.151	1.34E-18	YIL105C	SLM1	hom	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.151	1.66E-18	YNL288W	CAF40	hom	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.150	2.24E-18	YNL219C	ALG9	hom	Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.146	1.98E-17	YPL176C	TRE1	hom	Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication
0.142	1.40E-16	YMR099C	YMR099C	hom	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.139	7.37E-16	YNL183C	NPR1	hom	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.138	1.15E-15	YDR289C	RTT103	hom	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.133	8.96E-15	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.128	1.06E-13	YOL159C	YOL159C	hom	Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
0.125	3.76E-13	YFL033C	RIM15	hom	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.123	7.70E-13	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.122	1.27E-12	YJL085W	EXO70	het	Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress