YNL046W_p

Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL046W / YNL046W

Click on Significant Values for Screen Details ID:SGTC_184|Compound:1494-0393|FD-Score:-2.98|P-value:7.55E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.41|P-value:1.34E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.28|P-value:2.34E-4 ID:SGTC_442|Compound:cape|FD-Score:4.02|P-value:8.75E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-2.99|P-value:7.45E-4 ID:SGTC_458|Compound:nppb|FD-Score:5.90|P-value:1.55E-10 ID:SGTC_515|Compound:4092-1064|FD-Score:3.07|P-value:5.30E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.50|P-value:9.65E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.17|P-value:4.25E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.22|P-value:3.05E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.31|P-value:2.19E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.11|P-value:4.50E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.65|P-value:4.92E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.35|P-value:1.71E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.08|P-value:5.33E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.56|P-value:7.20E-5 ID:SGTC_1684|Compound:st024538|FD-Score:2.94|P-value:8.53E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.98|P-value:7.17E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:5.39E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.83|P-value:2.17E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.66|P-value:4.96E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.21|P-value:3.10E-4 ID:SGTC_2833|Compound:9001315|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-2.96|P-value:8.22E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.19|P-value:3.52E-4 ID:SGTC_3267|Compound:9137951|FD-Score:2.98|P-value:7.37E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.98|P-value:7.55E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.41|P-value:1.34E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.28|P-value:2.34E-4 ID:SGTC_442|Compound:cape|FD-Score:4.02|P-value:8.75E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-2.99|P-value:7.45E-4 ID:SGTC_458|Compound:nppb|FD-Score:5.90|P-value:1.55E-10 ID:SGTC_515|Compound:4092-1064|FD-Score:3.07|P-value:5.30E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.50|P-value:9.65E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.17|P-value:4.25E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.22|P-value:3.05E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.31|P-value:2.19E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.11|P-value:4.50E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.65|P-value:4.92E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.35|P-value:1.71E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.08|P-value:5.33E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.56|P-value:7.20E-5 ID:SGTC_1684|Compound:st024538|FD-Score:2.94|P-value:8.53E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.98|P-value:7.17E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.13|P-value:4.43E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:5.39E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.83|P-value:2.17E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.66|P-value:4.96E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.21|P-value:3.10E-4 ID:SGTC_2833|Compound:9001315|FD-Score:2.89|P-value:9.99E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-2.96|P-value:8.22E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-3.19|P-value:3.52E-4 ID:SGTC_3267|Compound:9137951|FD-Score:2.98|P-value:7.37E-4

Top fitness defect scores for YNL046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_458 nppb 5.90 133.0 µM 1.55E-10 2 1.83E-9
2 SGTC_1182 1222-0449 4.35 220.0 µM 1.71E-6 14 6.78E-6
3 SGTC_545 4218-0007 4.17 221.0 µM 4.25E-6 22 1.51E-5
4 SGTC_442 cape 4.02 100.0 µM 8.75E-6 14 2.87E-5
5 SGTC_2492 derrusnin 3.83 100.0 µM 2.17E-5 6 6.41E-5
6 SGTC_1043 0916-0009 3.65 19.3 µM 4.92E-5 30 1.32E-4
7 SGTC_1422 4031-0024 3.56 15.5 µM 7.20E-5 iron homeostasis 24 1.85E-4
8 SGTC_357 1325-0123 3.41 420.0 µM 1.34E-4 16 3.21E-4
9 SGTC_417 st075190 3.28 100.0 µM 2.34E-4 27 5.26E-4
10 SGTC_2821 7996764 3.21 71.4 µM 3.10E-4 73 6.75E-4
11 SGTC_732 3970-1727 3.11 52.7 µM 4.50E-4 30 9.40E-4
12 SGTC_515 4092-1064 3.07 102.0 µM 5.30E-4 plasma membrane duress 104 0.00109
13 SGTC_2490 carminic acid 3.06 95.4 µM 5.39E-4 24 0.00110
14 SGTC_1887 st057648 2.98 70.8 µM 7.17E-4 50 0.00142
15 SGTC_3267 9137951 2.98 49.5 µM 7.37E-4 28 0.00145
16 SGTC_1684 st024538 2.94 14.6 µM 8.53E-4 51 0.00166
17 SGTC_2833 9001315 2.89 45.5 µM 9.99E-4 amide catabolism 111 0.00191
18 SGTC_2696 st077691 2.88 74.3 µM 0.00104 85 0.00197
19 SGTC_1034 k072-0165 2.88 12.7 µM 0.00106 Golgi 79 0.00201
20 SGTC_716 1683-5115 2.88 658.0 µM 0.00107 77 0.00202

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.43E-16 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.132 1.41E-14 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.118 6.76E-12 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.111 1.36E-10 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.102 3.02E-9 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.101 4.40E-9 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.100 6.22E-9 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.095 3.53E-8 YDR286C_p YDR286C_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
0.093 7.38E-8 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.093 7.76E-8 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.087 4.19E-7 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.085 8.22E-7 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.083 1.28E-6 YBR046C ZTA1 hom NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
0.081 2.53E-6 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.080 3.24E-6 YGR091W PRP31 het Splicing factor, component of the U4/U6-U5 snRNP complex