YNL047C / SLM2

Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL047C / SLM2

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:3.09|P-value:3.48E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.55|P-value:6.80E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.46|P-value:7.54E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.83|P-value:1.86E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.89|P-value:7.54E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.17|P-value:3.50E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.19|P-value:2.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.40|P-value:7.62E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.42|P-value:9.85E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.63|P-value:3.59E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.86|P-value:8.53E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.14|P-value:2.87E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.31|P-value:1.46E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.92|P-value:8.72E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.03|P-value:4.45E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.64|P-value:2.01E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.52|P-value:5.67E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.15|P-value:2.78E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.07|P-value:3.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.78|P-value:1.33E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-3.09|P-value:4.61E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.51|P-value:7.98E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.20|P-value:2.93E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.63|P-value:3.55E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.84|P-value:9.11E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.10|P-value:3.35E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.63|P-value:3.04E-7 ID:SGTC_2837|Compound:9008476|FD-Score:-2.96|P-value:7.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-5.38|P-value:3.29E-9 ID:SGTC_2844|Compound:9010103|FD-Score:-4.71|P-value:1.97E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-5.32|P-value:4.83E-9 ID:SGTC_2878|Compound:9043973|FD-Score:-5.18|P-value:1.15E-8 ID:SGTC_2984|Compound:9022109|FD-Score:3.93|P-value:8.36E-6 ID:SGTC_2995|Compound:9067767|FD-Score:2.97|P-value:5.62E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-2.90|P-value:9.15E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.07|P-value:3.87E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.51|P-value:4.20E-7 ID:SGTC_3208|Compound:9114115|FD-Score:3.88|P-value:1.09E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.25|P-value:2.39E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-6.29|P-value:5.79E-12 ID:SGTC_3217|Compound:9129673|FD-Score:-6.72|P-value:2.01E-13 ID:SGTC_3218|Compound:9131285|FD-Score:2.99|P-value:5.15E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.31|P-value:1.88E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.09|P-value:3.48E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.55|P-value:6.80E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:2.83|P-value:9.63E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.46|P-value:7.54E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.83|P-value:1.86E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.18|P-value:2.48E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.31|P-value:1.40E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.89|P-value:7.54E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.17|P-value:3.50E-6 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.19|P-value:2.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:4.40|P-value:7.62E-7 ID:SGTC_1285|Compound:0929-0069|FD-Score:-4.42|P-value:9.85E-7 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.63|P-value:3.59E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:2.86|P-value:8.53E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.14|P-value:2.87E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.31|P-value:1.46E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.92|P-value:8.72E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.03|P-value:4.45E-4 ID:SGTC_1701|Compound:st028638|FD-Score:4.64|P-value:2.01E-7 ID:SGTC_1748|Compound:st037455|FD-Score:3.52|P-value:5.67E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.15|P-value:2.78E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.07|P-value:3.87E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-4.78|P-value:1.33E-7 ID:SGTC_2345|Compound:9052315|FD-Score:-3.09|P-value:4.61E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.51|P-value:7.98E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.20|P-value:2.93E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.63|P-value:3.55E-5 ID:SGTC_2787|Compound:5284540|FD-Score:2.84|P-value:9.11E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.10|P-value:3.35E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-4.63|P-value:3.04E-7 ID:SGTC_2837|Compound:9008476|FD-Score:-2.96|P-value:7.39E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-5.38|P-value:3.29E-9 ID:SGTC_2844|Compound:9010103|FD-Score:-4.71|P-value:1.97E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-5.32|P-value:4.83E-9 ID:SGTC_2878|Compound:9043973|FD-Score:-5.18|P-value:1.15E-8 ID:SGTC_2984|Compound:9022109|FD-Score:3.93|P-value:8.36E-6 ID:SGTC_2995|Compound:9067767|FD-Score:2.97|P-value:5.62E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-2.90|P-value:9.15E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.07|P-value:3.87E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.51|P-value:4.20E-7 ID:SGTC_3208|Compound:9114115|FD-Score:3.88|P-value:1.09E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.25|P-value:2.39E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-6.29|P-value:5.79E-12 ID:SGTC_3217|Compound:9129673|FD-Score:-6.72|P-value:2.01E-13 ID:SGTC_3218|Compound:9131285|FD-Score:2.99|P-value:5.15E-4 ID:SGTC_3261|Compound:9137475|FD-Score:-3.31|P-value:1.88E-4

Top fitness defect scores for YNL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1701 st028638 4.64 40.4 µM 2.01E-7 7 1.76E-6
2 SGTC_3191 9110352 4.51 49.5 µM 4.20E-7 3 3.30E-6
3 SGTC_1262 0737-0114 4.40 49.6 µM 7.62E-7 13 5.46E-6
4 SGTC_1789 tunicamycin 4.15 25.0 nM 2.78E-6 unfolded protein response 39 1.64E-5
5 SGTC_2984 9022109 3.93 39.0 µM 8.36E-6 6 4.17E-5
6 SGTC_3208 9114115 3.88 49.5 µM 1.09E-5 39 5.23E-5
7 SGTC_2706 st078239 3.63 82.5 µM 3.55E-5 21 1.43E-4
8 SGTC_1286 0929-0070 3.63 131.0 µM 3.59E-5 25 1.44E-4
9 SGTC_1748 st037455 3.52 53.6 µM 5.67E-5 47 2.12E-4
10 SGTC_502 l-744,832 3.46 89.3 µM 7.54E-5 calcium & mitochondrial duress 48 2.70E-4
11 SGTC_788 1182-0090 3.31 188.0 µM 1.40E-4 endomembrane recycling 119 4.58E-4
12 SGTC_1496 4469-0713 3.31 57.4 µM 1.46E-4 40 4.74E-4
13 SGTC_622 1348-1566 3.27 26.3 µM 1.68E-4 40 5.36E-4
14 SGTC_1216 1165-0504 3.19 9.7 µM 2.32E-4 38 7.03E-4
15 SGTC_625 k213-0058 3.18 121.0 µM 2.48E-4 translation 181 7.45E-4
16 SGTC_1472 k841-0093 3.14 193.0 µM 2.87E-4 48 8.43E-4
17 SGTC_2792 7535235 3.10 81.8 µM 3.35E-4 fatty acid desaturase (OLE1) 68 9.62E-4
18 SGTC_163 1327-0036 3.09 7.5 µM 3.48E-4 174 9.94E-4
19 SGTC_2002 4023503 3.07 131.0 µM 3.87E-4 mitochondrial processes 81 0.00109
20 SGTC_3187 9109394 3.07 49.5 µM 3.87E-4 Golgi 71 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 2.15E-22 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.161 8.67E-21 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.156 1.10E-19 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.135 5.33E-15 YDR403W DIT1 hom Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
0.129 6.47E-14 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.128 1.16E-13 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.127 1.77E-13 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.126 3.09E-13 YDR325W YCG1 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.124 6.41E-13 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 9.16E-13 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.117 1.23E-11 YMR114C YMR114C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
0.117 1.39E-11 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.115 2.78E-11 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.115 3.45E-11 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.112 7.68E-11 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain