YNL065W / AQR1

Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL065W / AQR1

Click on Significant Values for Screen Details ID:SGTC_130|Compound:0136-0219|FD-Score:3.41|P-value:1.11E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.05|P-value:4.84E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.94|P-value:1.01E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:4.12|P-value:4.05E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.26|P-value:2.10E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:2.98|P-value:6.43E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.01|P-value:5.66E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.75|P-value:2.53E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:1.17E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.91|P-value:7.99E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:5.37|P-value:3.04E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.20|P-value:2.57E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.60|P-value:4.71E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.03|P-value:6.37E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.66|P-value:3.68E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:-2.91|P-value:7.77E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.44|P-value:7.19E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.81|P-value:9.87E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:7.02|P-value:1.51E-14 ID:SGTC_1460|Compound:k062-0059|FD-Score:-4.47|P-value:6.07E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.21|P-value:2.41E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:1.17E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-3.00|P-value:5.61E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-2.93|P-value:7.23E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-2.93|P-value:7.19E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-2.88|P-value:8.93E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.87|P-value:9.16E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.12|P-value:3.73E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.93|P-value:1.00E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.99|P-value:5.92E-4 ID:SGTC_2334|Compound:9017922|FD-Score:2.98|P-value:6.36E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.84|P-value:1.62E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.84|P-value:1.54E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.11|P-value:3.86E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.43|P-value:1.01E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.44|P-value:9.48E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.89|P-value:8.36E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.28|P-value:1.80E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.13|P-value:3.39E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.15|P-value:3.12E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.48|P-value:8.45E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.32|P-value:1.63E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.71|P-value:2.84E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.90|P-value:8.18E-11 ID:SGTC_3018|Compound:9082602|FD-Score:3.00|P-value:5.90E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.77|P-value:2.17E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.48|P-value:8.48E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.63|P-value:4.20E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.52|P-value:6.71E-5 ID:SGTC_3141|Compound:9094609|FD-Score:2.94|P-value:7.30E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.46|P-value:8.94E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-4.09|P-value:4.47E-6 ID:SGTC_130|Compound:0136-0219|FD-Score:3.41|P-value:1.11E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:3.05|P-value:4.84E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.20|P-value:2.66E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.94|P-value:1.01E-5 ID:SGTC_478|Compound:N-arachidonylglycine|FD-Score:4.12|P-value:4.05E-6 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.26|P-value:2.10E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:2.98|P-value:6.43E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.01|P-value:5.66E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.75|P-value:2.53E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.91|P-value:1.17E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.91|P-value:7.99E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:5.37|P-value:3.04E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:-3.20|P-value:2.57E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.60|P-value:4.71E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.03|P-value:6.37E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.66|P-value:3.68E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:-2.91|P-value:7.77E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.22|P-value:2.52E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-4.44|P-value:7.19E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.81|P-value:9.87E-8 ID:SGTC_1456|Compound:k015-0012|FD-Score:7.02|P-value:1.51E-14 ID:SGTC_1460|Compound:k062-0059|FD-Score:-4.47|P-value:6.07E-7 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.29|P-value:1.88E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.21|P-value:2.41E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:1.17E-5 ID:SGTC_1748|Compound:st037455|FD-Score:-3.00|P-value:5.61E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-2.93|P-value:7.23E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-2.93|P-value:7.19E-4 ID:SGTC_2137|Compound:5261020|FD-Score:-2.88|P-value:8.93E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-2.87|P-value:9.16E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.12|P-value:3.73E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.93|P-value:1.00E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-2.99|P-value:5.92E-4 ID:SGTC_2334|Compound:9017922|FD-Score:2.98|P-value:6.36E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.84|P-value:1.62E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.84|P-value:1.54E-5 ID:SGTC_2365|Compound:9042475|FD-Score:3.11|P-value:3.86E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.43|P-value:1.01E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.44|P-value:9.48E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.89|P-value:8.36E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.28|P-value:1.80E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.13|P-value:3.39E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.15|P-value:3.12E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.26|P-value:2.02E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.48|P-value:8.45E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.32|P-value:1.63E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.71|P-value:2.84E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.90|P-value:8.18E-11 ID:SGTC_3018|Compound:9082602|FD-Score:3.00|P-value:5.90E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.77|P-value:2.17E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.48|P-value:8.48E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.63|P-value:4.20E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-3.52|P-value:6.71E-5 ID:SGTC_3141|Compound:9094609|FD-Score:2.94|P-value:7.30E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.46|P-value:8.94E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.17|P-value:3.09E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-4.09|P-value:4.47E-6

Top fitness defect scores for YNL065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1456 k015-0012 7.02 13.0 µM 1.51E-14 2 1.14E-12
2 SGTC_2997 9067075 5.90 71.4 µM 8.18E-11 unfolded protein response 19 1.78E-9
3 SGTC_815 1582-0027 5.37 36.9 µM 3.04E-9 5 3.92E-8
4 SGTC_1454 4239-0054 4.81 42.6 µM 9.87E-8 14 7.72E-7
5 SGTC_2567 aureobasidin a 4.28 60.0 nM 1.80E-6 79 9.32E-6
6 SGTC_478 N-arachidonylglycine 4.12 10.0 µM 4.05E-6 3 1.87E-5
7 SGTC_1083 didemethylchlorpromazine sulfoxide 4.03 707.4 nM 6.37E-6 redox potentiating 79 2.75E-5
8 SGTC_388 3',4'-dichloroisocoumarin 3.94 16.7 µM 1.01E-5 14 4.10E-5
9 SGTC_683 panaxydol 3.91 45.0 µM 1.17E-5 sphingolipid biosynthesis & PDR1 40 4.63E-5
10 SGTC_1739 st037196 3.91 92.5 µM 1.17E-5 26 4.65E-5
11 SGTC_2338 7999974 3.84 200.0 µM 1.62E-5 26 6.13E-5
12 SGTC_645 0845-0943 3.75 5.4 µM 2.53E-5 60S ribosome export 12 9.01E-5
13 SGTC_1147 3809-1045 3.66 12.3 µM 3.68E-5 32 1.24E-4
14 SGTC_3125 9127534 3.63 49.5 µM 4.20E-5 18 1.39E-4
15 SGTC_2764 methyldopa 3.48 94.7 µM 8.45E-5 30 2.54E-4
16 SGTC_3083 9117465 3.48 49.5 µM 8.48E-5 35 2.55E-4
17 SGTC_3145 9085516 3.46 49.5 µM 8.94E-5 fatty acid desaturase (OLE1) 46 2.67E-4
18 SGTC_2413 inermin 3.43 26.1 µM 1.01E-4 77 2.97E-4
19 SGTC_130 0136-0219 3.41 337.7 µM 1.11E-4 40 3.20E-4
20 SGTC_2934 9036370 3.32 36.9 µM 1.63E-4 55 4.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 7.09E-19 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.143 6.80E-17 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.126 2.14E-13 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.115 2.84E-11 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.113 4.38E-11 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.102 3.86E-9 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.100 6.22E-9 YLR180W SAM1 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication
0.097 1.95E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.093 7.00E-8 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.092 1.20E-7 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.090 1.70E-7 YML069W POB3 het Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress
0.088 3.20E-7 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.088 3.81E-7 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.085 7.82E-7 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.083 1.34E-6 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene