YNL067W / RPL9B

Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL067W / RPL9B

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:2.90|P-value:4.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.95|P-value:4.22E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.97|P-value:7.66E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.00|P-value:3.39E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.95|P-value:8.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.04|P-value:5.73E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:2.75|P-value:8.83E-4 ID:SGTC_264|Compound:promethazine|FD-Score:2.95|P-value:4.08E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.51|P-value:8.27E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.02|P-value:7.36E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.34|P-value:3.01E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.21|P-value:2.93E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.29|P-value:1.01E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.50|P-value:8.80E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.35|P-value:1.67E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.52|P-value:7.86E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.79|P-value:7.51E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.72|P-value:9.88E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.06|P-value:2.64E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:2.74|P-value:9.30E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.52|P-value:5.43E-7 ID:SGTC_1426|Compound:4048-4480|FD-Score:-2.98|P-value:7.28E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.42|P-value:3.51E-7 ID:SGTC_1547|Compound:harmine|FD-Score:-3.40|P-value:1.34E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.88|P-value:5.39E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-2.97|P-value:7.47E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.77|P-value:8.29E-4 ID:SGTC_1723|Compound:st034307|FD-Score:2.77|P-value:8.23E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.60|P-value:5.65E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.12|P-value:4.23E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-2.90|P-value:9.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.83|P-value:7.87E-6 ID:SGTC_1851|Compound:st056236|FD-Score:2.82|P-value:6.69E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.98|P-value:3.65E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.26|P-value:1.13E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.70|P-value:1.51E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-5.58|P-value:7.50E-10 ID:SGTC_2061|Compound:5245884|FD-Score:3.11|P-value:2.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:1.35E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.62|P-value:4.99E-5 ID:SGTC_2296|Compound:7971656|FD-Score:2.88|P-value:5.35E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.20|P-value:2.14E-12 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.38|P-value:2.88E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.62|P-value:2.21E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-2.94|P-value:8.40E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.93|P-value:8.89E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-2.96|P-value:7.74E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:2.90|P-value:4.90E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.95|P-value:4.22E-8 ID:SGTC_137|Compound:0438-0332|FD-Score:-2.97|P-value:7.66E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.00|P-value:3.39E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-2.95|P-value:8.13E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.04|P-value:5.73E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:2.75|P-value:8.83E-4 ID:SGTC_264|Compound:promethazine|FD-Score:2.95|P-value:4.08E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.51|P-value:8.27E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.02|P-value:7.36E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.34|P-value:3.01E-12 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.21|P-value:2.93E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.29|P-value:1.01E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.50|P-value:8.80E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.35|P-value:1.67E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:-3.52|P-value:7.86E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.79|P-value:7.51E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:2.72|P-value:9.88E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.06|P-value:2.64E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:2.74|P-value:9.30E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-4.52|P-value:5.43E-7 ID:SGTC_1426|Compound:4048-4480|FD-Score:-2.98|P-value:7.28E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.42|P-value:3.51E-7 ID:SGTC_1547|Compound:harmine|FD-Score:-3.40|P-value:1.34E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.88|P-value:5.39E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-2.97|P-value:7.47E-4 ID:SGTC_1672|Compound:st016598|FD-Score:2.77|P-value:8.29E-4 ID:SGTC_1723|Compound:st034307|FD-Score:2.77|P-value:8.23E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-3.60|P-value:5.65E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.12|P-value:4.23E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-2.90|P-value:9.90E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.83|P-value:7.87E-6 ID:SGTC_1851|Compound:st056236|FD-Score:2.82|P-value:6.69E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.98|P-value:3.65E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.26|P-value:1.13E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.70|P-value:1.51E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-5.58|P-value:7.50E-10 ID:SGTC_2061|Compound:5245884|FD-Score:3.11|P-value:2.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.90|P-value:1.35E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.62|P-value:4.99E-5 ID:SGTC_2296|Compound:7971656|FD-Score:2.88|P-value:5.35E-4 ID:SGTC_2479|Compound:5617353|FD-Score:6.20|P-value:2.14E-12 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.12|P-value:4.31E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.38|P-value:2.88E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.62|P-value:2.21E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-2.94|P-value:8.40E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-2.93|P-value:8.89E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-2.96|P-value:7.74E-4

Top fitness defect scores for YNL067W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2479 5617353 6.20 43.9 µM 2.14E-12 5 2.80E-10
2 SGTC_1468 k284-1086 4.42 134.0 µM 3.51E-7 DNA intercalators 23 5.04E-6
3 SGTC_1846 st056244 3.83 14.8 µM 7.87E-6 30 6.37E-5
4 SGTC_1993 st073995 3.70 70.8 µM 1.51E-5 28 1.08E-4
5 SGTC_2688 kanamycin b 3.62 96.7 µM 2.21E-5 calcium & mitochondrial duress 423 1.48E-4
6 SGTC_751 0833-0568 3.29 350.0 µM 1.01E-4 46 5.08E-4
7 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.26 62.6 µM 1.13E-4 TSC3-RPN4 30 5.56E-4
8 SGTC_2061 5245884 3.11 81.0 µM 2.13E-4 tubulin folding & SWR complex 57 9.34E-4
9 SGTC_1196 1588-0294 3.06 184.0 µM 2.64E-4 44 0.00111
10 SGTC_145 3737-0113 3.00 38.4 µM 3.39E-4 DNA intercalators 130 0.00137
11 SGTC_1854 st056233 2.98 32.9 µM 3.65E-4 amide catabolism 55 0.00145
12 SGTC_264 promethazine 2.95 12.5 mM 4.08E-4 DNA intercalators 123 0.00159
13 SGTC_9 0092-0002 2.90 10.4 µM 4.90E-4 82 0.00184
14 SGTC_2296 7971656 2.88 126.5 µM 5.35E-4 104 0.00198
15 SGTC_1589 2',5'-dimethoxyflavone 2.88 47.2 µM 5.39E-4 67 0.00199
16 SGTC_1851 st056236 2.82 18.9 µM 6.69E-4 67 0.00238
17 SGTC_911 3456-4043 2.79 236.0 µM 7.51E-4 mitochondrial processes 104 0.00261
18 SGTC_1723 st034307 2.77 2.5 µM 8.23E-4 mitochondrial processes 96 0.00281
19 SGTC_1672 st016598 2.77 6.5 µM 8.29E-4 endomembrane recycling 145 0.00283
20 SGTC_187 1488-2104 2.75 32.7 µM 8.83E-4 calcium & mitochondrial duress 93 0.00298

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.41E-51 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.223 6.34E-39 YDR156W RPA14 hom RNA polymerase I subunit A14
0.206 2.31E-33 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.205 3.67E-33 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.196 2.15E-30 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.187 8.71E-28 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.186 1.33E-27 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.40E-27 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.162 3.06E-21 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.162 5.58E-21 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.155 2.11E-19 YDL137W ARF2 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.154 2.30E-19 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.153 6.02E-19 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.151 1.47E-18 YDR486C VPS60 hom Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
0.151 1.54E-18 YNL109W_d YNL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C