YNL067W-B_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL067W-B / YNL067W-B

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.94|P-value:8.58E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:9.17|P-value:1.79E-18 ID:SGTC_170|Compound:4197-0004|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.81|P-value:1.58E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.60|P-value:2.97E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.86|P-value:1.16E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.42|P-value:5.47E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.59|P-value:3.46E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.76|P-value:1.85E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.37|P-value:6.49E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-5.05|P-value:7.44E-7 ID:SGTC_799|Compound:1310-0557|FD-Score:6.61|P-value:1.83E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:8.33|P-value:1.42E-15 ID:SGTC_806|Compound:3966-4455|FD-Score:3.34|P-value:8.09E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.77|P-value:1.83E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.00|P-value:7.78E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.51|P-value:4.59E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.30|P-value:9.15E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.36|P-value:7.53E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.34|P-value:7.26E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:7.04E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.85|P-value:1.22E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.81|P-value:1.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:8.05E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.44|P-value:5.82E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.32|P-value:7.65E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.27|P-value:9.01E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.52|P-value:2.65E-10 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.13|P-value:4.72E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.91|P-value:1.10E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.81|P-value:1.58E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.33|P-value:8.14E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:-3.40|P-value:5.88E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.73|P-value:1.86E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.94|P-value:8.58E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:9.17|P-value:1.79E-18 ID:SGTC_170|Compound:4197-0004|FD-Score:3.59|P-value:3.45E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.81|P-value:1.58E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.60|P-value:2.97E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.86|P-value:1.16E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.42|P-value:5.47E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.59|P-value:3.46E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.76|P-value:1.85E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.37|P-value:6.49E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-5.05|P-value:7.44E-7 ID:SGTC_799|Compound:1310-0557|FD-Score:6.61|P-value:1.83E-10 ID:SGTC_802|Compound:4112-3352|FD-Score:8.33|P-value:1.42E-15 ID:SGTC_806|Compound:3966-4455|FD-Score:3.34|P-value:8.09E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.87|P-value:1.25E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.77|P-value:1.83E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.00|P-value:7.78E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.51|P-value:4.59E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.30|P-value:9.15E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.36|P-value:7.53E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.34|P-value:7.26E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.99|P-value:7.04E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.85|P-value:1.22E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:-3.81|P-value:1.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:8.05E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.44|P-value:5.82E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.32|P-value:7.65E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.27|P-value:9.01E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-6.52|P-value:2.65E-10 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.13|P-value:4.72E-5 ID:SGTC_2783|Compound:7738165|FD-Score:3.91|P-value:1.10E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.81|P-value:1.58E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.33|P-value:8.14E-4 ID:SGTC_3064|Compound:1327-0027|FD-Score:-3.40|P-value:5.88E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.48|P-value:5.08E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.73|P-value:1.86E-4

Top fitness defect scores for YNL067W-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_87 0100-0052 9.17 35.5 µM 1.79E-18 10 2.45E-20
2 SGTC_802 4112-3352 8.33 742.0 µM 1.42E-15 1 4.04E-17
3 SGTC_799 1310-0557 6.61 151.0 µM 1.83E-10 superoxide 3 1.86E-11
4 SGTC_2578 7,8-dihydroxyflavone 4.13 64.4 µM 4.72E-5 28 1.84E-5
5 SGTC_952 1185-0122 4.00 232.0 µM 7.78E-5 18 3.19E-5
6 SGTC_2783 7738165 3.91 71.4 µM 1.10E-4 29 4.69E-5
7 SGTC_823 0417-1665 3.87 178.0 µM 1.25E-4 41 5.41E-5
8 SGTC_3052 9092717 3.81 49.5 µM 1.58E-4 34 6.98E-5
9 SGTC_899 1083-0020 3.77 478.0 µM 1.83E-4 26 8.22E-5
10 SGTC_612 0302-0167 3.76 22.4 µM 1.85E-4 copper-dependent oxidative stress 42 8.35E-5
11 SGTC_170 4197-0004 3.59 226.0 µM 3.45E-4 26 1.66E-4
12 SGTC_581 0958-0271 3.59 211.0 µM 3.46E-4 64 1.66E-4
13 SGTC_1029 k015-0030 3.51 64.7 µM 4.59E-4 47 2.28E-4
14 SGTC_3134 9127454 3.48 49.5 µM 5.08E-4 20 2.55E-4
15 SGTC_1466 k213-0079 3.44 57.5 µM 5.65E-4 33 2.86E-4
16 SGTC_2409 alverine citrate 3.44 64.0 µM 5.82E-4 70 2.96E-4
17 SGTC_1127 asiatic acid 3.36 681.4 nM 7.53E-4 42 3.93E-4
18 SGTC_2100 5377183 3.34 190.0 µM 8.05E-4 60S ribosome export 30 4.24E-4
19 SGTC_806 3966-4455 3.34 5.9 µM 8.09E-4 46 4.26E-4
20 SGTC_3057 9095946 3.33 49.5 µM 8.14E-4 Golgi 28 4.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.84E-26 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.174 3.50E-24 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.149 3.83E-18 YDR156W RPA14 hom RNA polymerase I subunit A14
0.127 1.36E-13 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.125 4.07E-13 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.122 1.27E-12 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.116 1.77E-11 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.108 3.58E-10 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.103 2.42E-9 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.102 3.76E-9 YGL078C DBP3 hom RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
0.101 4.39E-9 YLR217W_d YLR217W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
0.097 1.91E-8 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.094 4.85E-8 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.094 5.63E-8 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.093 7.50E-8 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters