YNL070W / TOM7

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL070W / TOM7

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.52|P-value:8.84E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.44|P-value:4.25E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.49|P-value:7.21E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:4.40|P-value:1.49E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.92|P-value:9.92E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:8.67|P-value:6.94E-17 ID:SGTC_67|Compound:0335-0847|FD-Score:4.10|P-value:4.94E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.88|P-value:1.75E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.27|P-value:9.95E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-6.79|P-value:3.01E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.01|P-value:9.65E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:3.42|P-value:6.05E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.92|P-value:1.03E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.33|P-value:1.45E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.65|P-value:5.09E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.47|P-value:5.05E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.73|P-value:8.39E-14 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.24|P-value:2.10E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:9.43|P-value:1.20E-19 ID:SGTC_165|Compound:k038-0023|FD-Score:5.51|P-value:8.05E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.56|P-value:7.51E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.29|P-value:9.30E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.61|P-value:5.97E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.10|P-value:5.01E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.30|P-value:3.53E-23 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.31|P-value:6.77E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.92|P-value:7.44E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.73|P-value:3.51E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:4.00|P-value:7.25E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.52|P-value:4.20E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.95|P-value:8.81E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.36|P-value:7.23E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.06|P-value:3.90E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:6.47|P-value:3.65E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.05|P-value:5.54E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:7.62E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.53|P-value:7.13E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:7.92|P-value:2.15E-14 ID:SGTC_568|Compound:1193-0097|FD-Score:5.75|P-value:2.21E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.91|P-value:1.51E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.80|P-value:1.55E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.03|P-value:8.71E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:9.40|P-value:1.56E-19 ID:SGTC_706|Compound:4262-0057|FD-Score:3.98|P-value:7.95E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.73|P-value:3.44E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:4.80|P-value:2.55E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.49|P-value:1.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.50|P-value:8.34E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:3.44|P-value:5.66E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.11|P-value:4.87E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.68|P-value:3.32E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.57|P-value:5.90E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.83|P-value:1.05E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.01|P-value:1.15E-14 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.52|P-value:4.25E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.32|P-value:2.08E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.08|P-value:5.35E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_1516|Compound:st013856|FD-Score:5.25|P-value:2.92E-7 ID:SGTC_1526|Compound:st051518|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.72|P-value:9.53E-14 ID:SGTC_1627|Compound:st003713|FD-Score:6.78|P-value:5.27E-11 ID:SGTC_1635|Compound:st007035|FD-Score:4.83|P-value:2.17E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.30|P-value:1.20E-15 ID:SGTC_1754|Compound:st042065|FD-Score:4.35|P-value:1.79E-5 ID:SGTC_1760|Compound:st045453|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.70|P-value:2.29E-4 ID:SGTC_1801|Compound:st050089|FD-Score:7.12|P-value:5.67E-12 ID:SGTC_1803|Compound:st050068|FD-Score:5.43|P-value:1.19E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.51|P-value:3.34E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.20|P-value:3.30E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.37|P-value:1.61E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.78|P-value:1.68E-4 ID:SGTC_1974|Compound:st069448|FD-Score:6.09|P-value:3.41E-9 ID:SGTC_2021|Compound:4019055|FD-Score:7.57|P-value:2.64E-13 ID:SGTC_2054|Compound:5233173|FD-Score:5.61|P-value:4.81E-8 ID:SGTC_2057|Compound:5236571|FD-Score:3.52|P-value:4.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.51|P-value:4.18E-13 ID:SGTC_2269|Compound:7935389|FD-Score:4.70|P-value:3.96E-6 ID:SGTC_2274|Compound:7947094|FD-Score:5.00|P-value:9.98E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-3.93|P-value:7.29E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.18|P-value:3.63E-5 ID:SGTC_2354|Compound:9060492|FD-Score:6.19|P-value:1.93E-9 ID:SGTC_2367|Compound:9070478|FD-Score:6.79|P-value:4.98E-11 ID:SGTC_2570|Compound:licareol|FD-Score:4.02|P-value:6.79E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.33|P-value:6.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:7.15|P-value:4.81E-12 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:5.18E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:8.60|P-value:1.20E-16 ID:SGTC_2619|Compound:obliquin|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.01|P-value:7.11E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.56|P-value:2.12E-10 ID:SGTC_3096|Compound:9117468|FD-Score:3.65|P-value:2.73E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.44|P-value:4.36E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.27|P-value:1.20E-9 ID:SGTC_3162|Compound:9099653|FD-Score:3.92|P-value:9.85E-5 ID:SGTC_3186|Compound:9110464|FD-Score:4.13|P-value:4.47E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.30|P-value:8.93E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.55|P-value:3.90E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.77|P-value:6.33E-14 ID:SGTC_3321|Compound:9137793|FD-Score:4.52|P-value:8.91E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.17|P-value:4.40E-7 ID:SGTC_3351|Compound:9150312|FD-Score:5.05|P-value:7.74E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:4.52|P-value:8.84E-6 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.44|P-value:4.25E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.49|P-value:7.21E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:4.40|P-value:1.49E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-4.92|P-value:9.92E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:8.67|P-value:6.94E-17 ID:SGTC_67|Compound:0335-0847|FD-Score:4.10|P-value:4.94E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.88|P-value:1.75E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.27|P-value:9.95E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-6.79|P-value:3.01E-11 ID:SGTC_86|Compound:0417-1630|FD-Score:5.01|P-value:9.65E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:3.42|P-value:6.05E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.92|P-value:1.03E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.33|P-value:1.45E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.65|P-value:5.09E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.47|P-value:5.05E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.73|P-value:8.39E-14 ID:SGTC_157|Compound:1348-1695|FD-Score:-4.24|P-value:2.10E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:9.43|P-value:1.20E-19 ID:SGTC_165|Compound:k038-0023|FD-Score:5.51|P-value:8.05E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:4.56|P-value:7.51E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.56|P-value:2.81E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.29|P-value:9.30E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.61|P-value:5.97E-6 ID:SGTC_208|Compound:k072-0098|FD-Score:4.10|P-value:5.01E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.30|P-value:3.53E-23 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.31|P-value:6.77E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.92|P-value:7.44E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:4.73|P-value:3.51E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:4.00|P-value:7.25E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.52|P-value:4.20E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:3.95|P-value:8.81E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.36|P-value:7.23E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:6.06|P-value:3.90E-9 ID:SGTC_426|Compound:0988-0037|FD-Score:6.47|P-value:3.65E-10 ID:SGTC_439|Compound:amiodarone|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.05|P-value:5.54E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.27|P-value:7.62E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.53|P-value:7.13E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:7.92|P-value:2.15E-14 ID:SGTC_568|Compound:1193-0097|FD-Score:5.75|P-value:2.21E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:4.91|P-value:1.51E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.80|P-value:1.55E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.03|P-value:8.71E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:9.40|P-value:1.56E-19 ID:SGTC_706|Compound:4262-0057|FD-Score:3.98|P-value:7.95E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.73|P-value:3.44E-6 ID:SGTC_747|Compound:3448-8087|FD-Score:4.80|P-value:2.55E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.75|P-value:1.88E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.49|P-value:1.01E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:5.50|P-value:8.34E-8 ID:SGTC_888|Compound:0916-0002|FD-Score:3.44|P-value:5.66E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.11|P-value:4.87E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:5.68|P-value:3.32E-8 ID:SGTC_1027|Compound:k015-0025|FD-Score:5.57|P-value:5.90E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.83|P-value:1.05E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.01|P-value:1.15E-14 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.52|P-value:4.25E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.32|P-value:2.08E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.08|P-value:5.35E-5 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.44|P-value:5.65E-4 ID:SGTC_1516|Compound:st013856|FD-Score:5.25|P-value:2.92E-7 ID:SGTC_1526|Compound:st051518|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.72|P-value:9.53E-14 ID:SGTC_1627|Compound:st003713|FD-Score:6.78|P-value:5.27E-11 ID:SGTC_1635|Compound:st007035|FD-Score:4.83|P-value:2.17E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.86|P-value:1.26E-4 ID:SGTC_1712|Compound:st032288|FD-Score:8.30|P-value:1.20E-15 ID:SGTC_1754|Compound:st042065|FD-Score:4.35|P-value:1.79E-5 ID:SGTC_1760|Compound:st045453|FD-Score:3.35|P-value:7.46E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.70|P-value:2.29E-4 ID:SGTC_1801|Compound:st050089|FD-Score:7.12|P-value:5.67E-12 ID:SGTC_1803|Compound:st050068|FD-Score:5.43|P-value:1.19E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.51|P-value:3.34E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.20|P-value:3.30E-5 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.71|P-value:1.65E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.37|P-value:1.61E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.78|P-value:1.68E-4 ID:SGTC_1974|Compound:st069448|FD-Score:6.09|P-value:3.41E-9 ID:SGTC_2021|Compound:4019055|FD-Score:7.57|P-value:2.64E-13 ID:SGTC_2054|Compound:5233173|FD-Score:5.61|P-value:4.81E-8 ID:SGTC_2057|Compound:5236571|FD-Score:3.52|P-value:4.23E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:7.51|P-value:4.18E-13 ID:SGTC_2269|Compound:7935389|FD-Score:4.70|P-value:3.96E-6 ID:SGTC_2274|Compound:7947094|FD-Score:5.00|P-value:9.98E-7 ID:SGTC_2291|Compound:7917025|FD-Score:-3.93|P-value:7.29E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.18|P-value:3.63E-5 ID:SGTC_2354|Compound:9060492|FD-Score:6.19|P-value:1.93E-9 ID:SGTC_2367|Compound:9070478|FD-Score:6.79|P-value:4.98E-11 ID:SGTC_2570|Compound:licareol|FD-Score:4.02|P-value:6.79E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.33|P-value:6.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:7.15|P-value:4.81E-12 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.09|P-value:5.18E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:8.60|P-value:1.20E-16 ID:SGTC_2619|Compound:obliquin|FD-Score:4.20|P-value:3.41E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.01|P-value:7.11E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.56|P-value:2.12E-10 ID:SGTC_3096|Compound:9117468|FD-Score:3.65|P-value:2.73E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.44|P-value:4.36E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.80|P-value:1.56E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.27|P-value:1.20E-9 ID:SGTC_3162|Compound:9099653|FD-Score:3.92|P-value:9.85E-5 ID:SGTC_3186|Compound:9110464|FD-Score:4.13|P-value:4.47E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.30|P-value:8.93E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.55|P-value:3.90E-4 ID:SGTC_3311|Compound:9131146|FD-Score:7.77|P-value:6.33E-14 ID:SGTC_3321|Compound:9137793|FD-Score:4.52|P-value:8.91E-6 ID:SGTC_3322|Compound:9139058|FD-Score:5.17|P-value:4.40E-7 ID:SGTC_3351|Compound:9150312|FD-Score:5.05|P-value:7.74E-7

Top fitness defect scores for YNL070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 10.30 10.3 µM 3.53E-23 NEO1-PIK1 56 2.95E-25
2 SGTC_158 k038-0087 9.43 26.4 µM 1.20E-19 ubiquinone biosynthesis & proteasome 33 2.13E-21
3 SGTC_690 glyoxal 9.40 20.3 µM 1.56E-19 19 2.83E-21
4 SGTC_64 000l-0018 8.67 272.1 µM 6.94E-17 ubiquinone biosynthesis & proteasome 43 2.23E-18
5 SGTC_2584 androsterone 8.60 48.7 µM 1.20E-16 cell wall 25 4.06E-18
6 SGTC_1712 st032288 8.30 53.4 µM 1.20E-15 calcium & mitochondrial duress 41 5.00E-17
7 SGTC_1083 didemethylchlorpromazine sulfoxide 8.01 707.4 nM 1.15E-14 redox potentiating 14 5.92E-16
8 SGTC_528 3492-0019 7.92 172.0 µM 2.15E-14 calcium & mitochondrial duress 74 1.18E-15
9 SGTC_3311 9131146 7.77 2.9 µM 6.33E-14 cell wall 35 3.83E-15
10 SGTC_146 3448-8650 7.73 53.1 µM 8.39E-14 NEO1-PIK1 27 5.22E-15
11 SGTC_1597 7-benzyloxygramine 7.72 47.5 µM 9.53E-14 calcium & mitochondrial duress 27 6.00E-15
12 SGTC_2021 4019055 7.57 173.0 µM 2.64E-13 endomembrane recycling 25 1.83E-14
13 SGTC_2249 haloperidol 7.51 116.4 µM 4.18E-13 ergosterol depletion effects on membrane 28 3.02E-14
14 SGTC_2573 2',4'-dihydroxychalcone 7.15 15.0 µM 4.81E-12 9 4.37E-13
15 SGTC_1801 st050089 7.12 28.4 µM 5.67E-12 NEO1-PIK1 37 5.22E-13
16 SGTC_2367 9070478 6.79 135.4 µM 4.98E-11 cell wall 6 5.62E-12
17 SGTC_1627 st003713 6.78 25.6 µM 5.27E-11 calcium & mitochondrial duress 20 5.97E-12
18 SGTC_2688 kanamycin b 6.56 96.7 µM 2.12E-10 calcium & mitochondrial duress 126 2.75E-11
19 SGTC_426 0988-0037 6.47 14.6 µM 3.65E-10 ERAD & cell cycle 12 4.96E-11
20 SGTC_3152 9099253 6.27 49.5 µM 1.20E-9 NEO1-PIK1 52 1.82E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 2.36E-109 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.320 5.46E-81 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.307 5.56E-74 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.304 1.53E-72 YKR006C MRPL13 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.301 4.92E-71 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.295 1.94E-68 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.276 1.69E-59 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.274 5.58E-59 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.273 1.35E-58 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.271 1.31E-57 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.271 2.56E-57 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.269 1.58E-56 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.266 1.21E-55 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication
0.264 1.48E-54 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.263 4.63E-54 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane