YNL075W / IMP4

Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL075W / IMP4

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.20|P-value:4.18E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:2.99|P-value:8.97E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:2.96|P-value:9.78E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.08|P-value:6.49E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.48|P-value:1.60E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:12.90|P-value:7.88E-41 ID:SGTC_195|Compound:4234-0266|FD-Score:3.14|P-value:5.26E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.58|P-value:9.74E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.24|P-value:3.66E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.01|P-value:1.54E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.21|P-value:4.00E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.58|P-value:9.76E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:3.49E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.86|P-value:2.24E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:4.85|P-value:2.44E-7 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.01|P-value:2.39E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.31|P-value:5.95E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.95|P-value:1.97E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.52|P-value:1.33E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:5.99|P-value:2.66E-10 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.74|P-value:7.53E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.35|P-value:3.42E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.21|P-value:5.77E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.39|P-value:3.01E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.46|P-value:2.94E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.14|P-value:5.22E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.68|P-value:5.85E-7 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.55|P-value:1.14E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.23|P-value:3.79E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:6.83|P-value:7.82E-13 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.20|P-value:3.53E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.72|P-value:5.31E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.21|P-value:4.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.13|P-value:5.36E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.61|P-value:3.00E-9 ID:SGTC_1521|Compound:st012942|FD-Score:5.20|P-value:3.45E-8 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.21|P-value:5.77E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1590|Compound:st077108|FD-Score:6.65|P-value:2.86E-12 ID:SGTC_1634|Compound:st006576|FD-Score:3.76|P-value:4.48E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.00|P-value:8.70E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.26|P-value:4.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.04|P-value:7.50E-4 ID:SGTC_2004|Compound:4023728|FD-Score:8.47|P-value:9.88E-19 ID:SGTC_2022|Compound:5136654|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.44|P-value:2.46E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.26|P-value:3.32E-4 ID:SGTC_2206|Compound:7254556|FD-Score:-3.67|P-value:1.01E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.76|P-value:4.47E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.09|P-value:8.81E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.98|P-value:2.64E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.11|P-value:5.81E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.02|P-value:1.47E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.28|P-value:3.12E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.08|P-value:6.46E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.35|P-value:3.48E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.57|P-value:1.01E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.20|P-value:4.18E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:2.99|P-value:8.97E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:2.96|P-value:9.78E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.08|P-value:6.49E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:3.43|P-value:1.74E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:4.48|P-value:1.60E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.45|P-value:1.61E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:12.90|P-value:7.88E-41 ID:SGTC_195|Compound:4234-0266|FD-Score:3.14|P-value:5.26E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.58|P-value:9.74E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:3.24|P-value:3.66E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.53|P-value:1.73E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.01|P-value:1.54E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.21|P-value:4.00E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:4.58|P-value:9.76E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:2.99|P-value:9.06E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.78|P-value:3.49E-7 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.86|P-value:2.24E-7 ID:SGTC_599|Compound:1935-0052|FD-Score:4.85|P-value:2.44E-7 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.01|P-value:2.39E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.31|P-value:5.95E-6 ID:SGTC_617|Compound:3770-0098|FD-Score:3.95|P-value:1.97E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.52|P-value:1.33E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:5.99|P-value:2.66E-10 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.74|P-value:7.53E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.35|P-value:3.42E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:-3.21|P-value:5.77E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.39|P-value:3.01E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.46|P-value:2.94E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.14|P-value:5.22E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.68|P-value:5.85E-7 ID:SGTC_1355|Compound:1499-0035|FD-Score:4.55|P-value:1.14E-6 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.23|P-value:3.79E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:6.83|P-value:7.82E-13 ID:SGTC_1382|Compound:3002-2117|FD-Score:5.20|P-value:3.53E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.46|P-value:1.57E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.72|P-value:5.31E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.20|P-value:4.16E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.21|P-value:4.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.13|P-value:5.36E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.61|P-value:3.00E-9 ID:SGTC_1521|Compound:st012942|FD-Score:5.20|P-value:3.45E-8 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.21|P-value:5.77E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.02|P-value:7.95E-4 ID:SGTC_1590|Compound:st077108|FD-Score:6.65|P-value:2.86E-12 ID:SGTC_1634|Compound:st006576|FD-Score:3.76|P-value:4.48E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.00|P-value:8.70E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_1802|Compound:st050112|FD-Score:-3.25|P-value:5.01E-4 ID:SGTC_1896|Compound:st058441|FD-Score:-3.26|P-value:4.87E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.04|P-value:7.50E-4 ID:SGTC_2004|Compound:4023728|FD-Score:8.47|P-value:9.88E-19 ID:SGTC_2022|Compound:5136654|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.44|P-value:2.46E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.26|P-value:3.32E-4 ID:SGTC_2206|Compound:7254556|FD-Score:-3.67|P-value:1.01E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.76|P-value:4.47E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-3.09|P-value:8.81E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.98|P-value:2.64E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.18|P-value:4.56E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.11|P-value:5.81E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.02|P-value:1.47E-5 ID:SGTC_2927|Compound:9011802|FD-Score:3.28|P-value:3.12E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.56|P-value:1.06E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.08|P-value:6.46E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.14|P-value:5.16E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.23|P-value:3.74E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.35|P-value:3.48E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.57|P-value:1.01E-4

Top fitness defect scores for YNL075W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_184 1494-0393 12.90 24.7 µM 7.88E-41 2 1.68E-38 3.26
2 SGTC_2004 4023728 8.47 41.9 µM 9.88E-19 9 1.18E-17 0.04
3 SGTC_1380 2291-0730 6.83 164.0 µM 7.82E-13 1 4.24E-12 1.83
4 SGTC_1590 st077108 6.65 57.8 µM 2.86E-12 1 1.44E-11 1.07
5 SGTC_851 0394-0702 5.99 453.0 µM 2.66E-10 mitochondrial processes 10 1.03E-9 0.18
6 SGTC_1465 k213-0056 5.61 144.0 µM 3.00E-9 DNA intercalators 2 1.00E-8 0.35
7 SGTC_1521 st012942 5.20 49.4 µM 3.45E-8 3 9.98E-8 1.17
8 SGTC_1382 3002-2117 5.20 298.0 µM 3.53E-8 2 1.02E-7 0.88
9 SGTC_445 e6 berbamine 4.86 66.0 µM 2.24E-7 NEO1-PIK1 19 5.79E-7 0.05
10 SGTC_599 1935-0052 4.85 86.5 µM 2.44E-7 2 6.27E-7 0.95
11 SGTC_341 1486-1430 4.78 230.0 µM 3.49E-7 18 8.78E-7 0.56
12 SGTC_1347 1493-0251 4.68 600.0 nM 5.85E-7 mitochondrial response to ROS 3 1.43E-6 0.56
13 SGTC_212 3807-4682 4.58 38.8 µM 9.74E-7 tubulin folding & SWR complex 20 2.31E-6 0.14
14 SGTC_309 k408-0051 4.58 1.5 µM 9.76E-7 17 2.31E-6 0.02
15 SGTC_1355 1499-0035 4.55 1.7 µM 1.14E-6 1 2.67E-6 0.39
16 SGTC_800 3448-7362 4.52 155.0 µM 1.33E-6 translation 39 3.09E-6 0.01
17 SGTC_81 0411-0046 4.48 10.0 µM 1.60E-6 33 3.67E-6 0.08
18 SGTC_1437 4092-1038 4.10 11.6 µM 1.01E-5 5 2.08E-5 0.38
19 SGTC_2627 acetyl isogambogic acid 4.02 100.0 µM 1.47E-5 TSC3-RPN4 4 2.96E-5 0.20
20 SGTC_895 0964-0006 4.01 13.7 µM 1.49E-5 13 2.98E-5 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 4.32E-62 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.238 2.56E-44 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.211 4.37E-35 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.158 3.10E-20 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.155 2.00E-19 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.147 1.18E-17 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.133 1.22E-14 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.130 3.79E-14 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.125 4.10E-13 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.119 5.51E-12 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.117 1.00E-11 YMR001C-A_p YMR001C-A_p hom Putative protein of unknown function
0.114 2.96E-11 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.114 3.24E-11 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.108 3.34E-10 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.108 3.44E-10 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein